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FLASH GENE

Symbol

TNFRSF10A

contributors: mct - updated : 07-01-2015

HGNC name	tumor necrosis factor receptor superfamily, member 10a
HGNC id	11904

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus       moderately Reproductive female system ovary     highly   male system prostate     moderately Respiratory respiratory tract trachea     predominantly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a putative signal peptide
	three extracellular cysteine-rich pseudorepeats typical for TNFR superfamily
	a preligand assembly domain (PLAD) in CRD1 mediating ligand-independent receptor assembly and signaling
	a small cytoplasmic tail with the DEATH domain

conjugated

GlycoP , PhosphoP

mono polymer

homomer , trimer

HOMOLOGY

intraspecies

homolog to TNF

Homologene

FAMILY

tumor necrosis factor receptor superfamily

CATEGORY

tumor suppressor , receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
text	type I transmembrane protein

basic FUNCTION	inducing a caspase-dependent apoptotic pathway
	acting as a receptor for the cytotoxic ligand TNFSF10
	promoting the activation of NF-kappa-B
	with TNFSF10 and TNFRSF10B, play an important role in inflammation

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with TRADD and RIP
	binding to APO2L
	endogenous MARCHF8 regulates the steady-state cell surface expression of TNFRS10A
	TNK2 is an essential player in the spatial regulation of TNFSR10A, TNFSR10B
	DDIT3 and KAT2A cooperatively up-regulate TNFRSF10A and TNFRSF10B

cell & other

REGULATION

induced by	TP53 inducible
		alpha-tocopheryl succinate (alpha-TOS) in a p53-dependent manner

repressed by

HH (silencing by HH requires an intact GLI3 activity)

Other	regulated by TNFRSF10B
	only pro-apoptotic signaling through TNFRSF10A and TNFRSF10B has been found to be regulated by N- and O-glycosylation, respectively

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in nasopharyngeal cancer

Susceptibility

to cancer

Variant & Polymorphism SNP	A683C with tumor specific allele distribution
	A1322G G allele and A683C C allele are associated with increased risk for cancer

Candidate gene
Marker
Therapy target	cytotoxic agents capable of up-regulating the expression of TNFRSF10A and TNFRSF10B can sensitize cancer cells to TNFSF10 induced apoptosis

ANIMAL & CELL MODELS