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FLASH GENE

Symbol

ADAM19

contributors: mct - updated : 28-01-2012

HGNC name	ADAM metallopeptidase domain 19 (meltrin beta)
HGNC id	197

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	98.47 kb     23 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   transcription factor
text structure	putative binding sites for several transcription factors including Sp1, Sp3, NF-kappaB, and VDR

MAPPING

cloned

Y

linked

Y

status

provisional

Map	cen - D5S487 - [D5S2112 ,ADAM19 ] - D5S2525 - D5S512 - qter
Authors	Hirohata (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - splicing 3127 105 956 - 2001 11162584 NM_033274 23 splicing 6506 101 918 - 2001 11162584

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       predominantly Digestive intestine large intestine colon   highly Reproductive female system placenta     highly Homo sapiens Respiratory lung       predominantly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Homo sapiens Connective bone     highly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic progenitor cell Homo sapiens Lymphoid/Immune dendritic cell

cell lineage
cell lines	colorectal adenocarcinoma cells
fluid/secretion

at STAGE

physiological period

pregnancy

Text	placenta, high expression during nephrogenesis pointing to a role in growth promotion and regulation
	widely distributed in villous cytotrophoblast cells, syncytiotrophoblast cells, column trophoblasts, and villous capillary endothelial cells during early pregnancy (PMID :

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	domains similar to hemorrhagic snake venom proteins (HSVP) with a prodomain
	a Zn-binding site metalloproteinase
	a disintegrin-like domain
	a cysteine-rich domain
	an EGF-like repeat
	a transmembrane domain
	a cytoplasmic tail
	one disintegrin domain

conjugated

GlycoP , MetalloP

HOMOLOGY

interspecies

homolog to murine Mltnb

Homologene

FAMILY

ADAM (a disintegrin and metalloprotease domain) family

CATEGORY

adhesion , signaling

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,Golgi
text	expressed in the Golgi

basic FUNCTION	involved in myotube formation and osteoblast differentiation and /or osteoblast activity in bone
	playing a role in the processing of neuregulin
	contribute to heart development
	may play a significant role in tumor invasion that may be detrimental to patients survival
	has a constitutive alpha-secretase activity for APP
	plays crucial roles in nerve regeneration after a crush injury to the sciatic nerves
	role in Schwann cell differentiation and re-myelination in nerve regeneration
	functions as a modulator of juxtacrine signaling from axons that activate the Akt pathway and the EGR2 expression, which is the prerequisite for Schwann cell differentiation
	may participate in the coordinated regulation of human trophoblast cell behaviors during the process of placentation

CELLULAR PROCESS	protein, degradation
	cell organization/biogenesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

alpha 2-M

INTERACTION

DNA

RNA

small molecule	metal binding, cofactor,
	Zn2+

protein	CRIP2 associated with ADAM19 through its disintegrin (DI) domain, and cysteine-rich (Cys) domains (ADAM19 promotes the secretion of CRIP2)
	one of cleaving proteases of ATP6AP2 (ATP6AP2 is cleaved by ADAM19 in the Golgi resulting in two fragments, N-terminal and C-terminal fragment)

cell & other

cell-cell and cell matrix interaction

REGULATION

Other

important role of histone acetylation in the regulation of ADAM19

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   increasing tubular ADAM19 associated with declining renal function tumoral     --other   epigenetic dysregulation of ADAM19 may contribute to the neoplastic process in ovarian cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Meltrin-beta-deficient mice exhibited delayed sciatic functional recovery after the nerve crush