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FLASH GENE
Symbol PDK2 contributors: mct/npt - updated : 19-12-2017
HGNC name pyruvate dehydrogenase kinase, isozyme 2
HGNC id 8810
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C-terminal DW-motif playing a role in mediating communications between the dichloroacetate -, the nucleotide-, and the lipoyl domain-binding sites (Li 2009)
    • HOMOLOGY
    interspecies homolog to murine Pdk2
    homolog to C.elegans zk370.5
    Homologene
    FAMILY
  • PDK/BCKDK protein kinase family
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • inhibition of the mitochondrial pyruvate dehydrogenase complexe by phosphorylation of the E1 alpha subunit
  • with PDK3 and PDK4 are primary PPARbeta/delta target genes underlining the importance of the receptor in the control of metabolism (Degenhardt 2007)
  • regulation of glycolysis by PDK2, PDK4 functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells
  • PDK1 and PDK2 promote meiotic maturation, as their knockdown disturbs the assembly of the meiotic apparatus, without significantly altering ATP content
  • PDK2 and PDK4, key regulatory enzymes in glucose metabolism, mediate glycolytic metabolic shift in the DRG leading to painful diabetic neuropathy
  • preliminary positive role and potential mechanisms of PDK2 in chondrogenic differentiation of mesenchymal stem cells (MSCs)
  • promotes chondrogenic differentiation of mesenchymal stem cells by upregulation of SOX6 and activation of JNK/MAPK/ERK pathway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with OSBP9L (PDK2 substrate and negative regulator of Akt phosphorylation at the PDK2 site) (Lessmann 2007)
  • wild-type TP53 prevents manifestation of the Warburg effect by controlling PDK2
  • mitochondrial activation by inhibition of PDK2 suppresses HIF1a signaling and angiogenesis in cancer
  • PDK2, a key regulator in metabolic plasticity, phosphorylates PARL and regulates beta cleavage
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    digestiveliver 
    is a potential therapeutic target for nonalcoholic fatty liver disease
    ANIMAL & CELL MODELS