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FLASH GENE

Symbol

FOXF2

contributors: mct - updated : 28-04-2017

HGNC name	forkhead box F2
HGNC id	3810

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   was silenced in gastric cancer cell lines and cancer tissues by promoter methylation, which was negatively associated with mRNA expression tumoral     --low   indicates the early-onset metastasis and poor prognosis for patients with histological grade II and triple-negative breast cancer

Susceptibility

Variant & Polymorphism

Candidate gene	interesting candidate locus for stroke susceptibility
Marker	MAZ mRNA level, particularly in combination with the FOXF2 mRNA level, may serve as a prognostic marker for basal-like breast cancer (BLBC) patients
	FOXF2 methylation might be a useful prognostic biomarker for esophageal squamous cell carcinoma patients
	decreased FOXF2 expression is an independent predictive factor for poor prognosis of patients with non-small cell lung cancer (NSCLC), especially in stage I NSCLC
Therapy target

ANIMAL & CELL MODELS

	Foxf2(-/-) mice are perinatal lethal with multiple malformations
	Foxf2 knockout mice present with cleft palate in combination with hypoplasia of the genital tubercle