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FLASH GENE
Symbol FOXF2 contributors: mct - updated : 28-04-2017
HGNC name forkhead box F2
HGNC id 3810
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
was silenced in gastric cancer cell lines and cancer tissues by promoter methylation, which was negatively associated with mRNA expression
tumoral     --low  
indicates the early-onset metastasis and poor prognosis for patients with histological grade II and triple-negative breast cancer
Susceptibility
Variant & Polymorphism
Candidate gene
  • interesting candidate locus for stroke susceptibility
  • Marker
  • MAZ mRNA level, particularly in combination with the FOXF2 mRNA level, may serve as a prognostic marker for basal-like breast cancer (BLBC) patients
  • FOXF2 methylation might be a useful prognostic biomarker for esophageal squamous cell carcinoma patients
  • decreased FOXF2 expression is an independent predictive factor for poor prognosis of patients with non-small cell lung cancer (NSCLC), especially in stage I NSCLC
  • Therapy target
    ANIMAL & CELL MODELS
  • Foxf2(-/-) mice are perinatal lethal with multiple malformations
  • Foxf2 knockout mice present with cleft palate in combination with hypoplasia of the genital tubercle