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FLASH GENE

Symbol

FOXF2

contributors: mct - updated : 28-04-2017

HGNC name	forkhead box F2
HGNC id	3810

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue         stomach         Reproductive female system uterus cervix     Respiratory lung         Skin/Tegument skin

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	placenta,lung

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a forkhead (FH, winged helix) domain with two loops-wings on the C-terminal side of helix-turn-helix homeo domain

HOMOLOGY

interspecies

homolog to Drosophila homeo forkhead DNA binding domain

Homologene

FAMILY

HNF-3 forkhead family of transcriptional activator

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	embryonic transcriptional regulator of pulmonary genes
	having an independent role as a developmental regulator
	plays an important role in tissue development, extracellular matrix synthesis, and epithelial-mesenchymal interactions, implying that it may be associated with the metastatic capabilities of cancer cells
	FOXF2 signaling in smooth muscle cells is essential for intestinal development and serum response factor signaling
	is required for brain pericyte differentiation and development and maintenance of the blood-brain barrier
	FOXC1, GMDS, FOXF2, and FOXQ1 may represent loci for enhancer-driven changes in gene expression that could affect the developing embryo
	function of FOXF2 is to maintain the stringency of DNA replication, and its loss triggers dysregulation of DNA replication, which in turn activates the TP53 checkpoint pathway
	has a dual role in breast tumorigenesis and functions as either a tumor suppressor or an oncogene depending on the breast tumor subtype

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein	TBP, TF2B
	FOXF2 is a previously unrecognized regulator of cellular and systemic whole body glucose tolerance, at least in part, due to lower levels of IRS1
	FOXF2 attenuated MYOCD/SRF signaling in smooth muscle cells through direct binding to the N-terminal region of MYOCD
	SHH regulation of FOXF2 promotes cranial neural crest mesenchyme proliferation and is disrupted in cleft lip morphogenesis
	FOXF2 is a novel transcription target of MAZ and mediates the functions of MAZ
	FOXF2 directly bound the promoter of E3 ligase interferon regulatory factor 2-binding protein-like (IRF2BPL) and induced its transcriptional expression
	FOXF2 inhibited WNT signaling by inducing CTNNB1 protein ubiquitination and degradation independently of GSK3B

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   was silenced in gastric cancer cell lines and cancer tissues by promoter methylation, which was negatively associated with mRNA expression tumoral     --low   indicates the early-onset metastasis and poor prognosis for patients with histological grade II and triple-negative breast cancer

Susceptibility

Variant & Polymorphism

Candidate gene	interesting candidate locus for stroke susceptibility
Marker	MAZ mRNA level, particularly in combination with the FOXF2 mRNA level, may serve as a prognostic marker for basal-like breast cancer (BLBC) patients
	FOXF2 methylation might be a useful prognostic biomarker for esophageal squamous cell carcinoma patients
	decreased FOXF2 expression is an independent predictive factor for poor prognosis of patients with non-small cell lung cancer (NSCLC), especially in stage I NSCLC
Therapy target

ANIMAL & CELL MODELS

	Foxf2(-/-) mice are perinatal lethal with multiple malformations
	Foxf2 knockout mice present with cleft palate in combination with hypoplasia of the genital tubercle