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FLASH GENE
Symbol FOXF2 contributors: mct - updated : 28-04-2017
HGNC name forkhead box F2
HGNC id 3810
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map pter - FOXF2 - D6S477 - D6S1640 - cen
Authors Blixt (98)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2187 - 444 - Blixt (1998)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue   
 stomach    
Reproductivefemale systemuteruscervix  
Respiratorylung    
Skin/Tegumentskin    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text placenta,lung
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a forkhead (FH, winged helix) domain with two loops-wings on the C-terminal side of helix-turn-helix homeo domain
    • HOMOLOGY
    interspecies homolog to Drosophila homeo forkhead DNA binding domain
    Homologene
    FAMILY HNF-3 forkhead family of transcriptional activator
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • embryonic transcriptional regulator of pulmonary genes
  • having an independent role as a developmental regulator
  • plays an important role in tissue development, extracellular matrix synthesis, and epithelial-mesenchymal interactions, implying that it may be associated with the metastatic capabilities of cancer cells
  • FOXF2 signaling in smooth muscle cells is essential for intestinal development and serum response factor signaling
  • is required for brain pericyte differentiation and development and maintenance of the blood-brain barrier
  • FOXC1, GMDS, FOXF2, and FOXQ1 may represent loci for enhancer-driven changes in gene expression that could affect the developing embryo
  • function of FOXF2 is to maintain the stringency of DNA replication, and its loss triggers dysregulation of DNA replication, which in turn activates the TP53 checkpoint pathway
  • has a dual role in breast tumorigenesis and functions as either a tumor suppressor or an oncogene depending on the breast tumor subtype
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • TBP, TF2B
  • FOXF2 is a previously unrecognized regulator of cellular and systemic whole body glucose tolerance, at least in part, due to lower levels of IRS1
  • FOXF2 attenuated MYOCD/SRF signaling in smooth muscle cells through direct binding to the N-terminal region of MYOCD
  • SHH regulation of FOXF2 promotes cranial neural crest mesenchyme proliferation and is disrupted in cleft lip morphogenesis
  • FOXF2 is a novel transcription target of MAZ and mediates the functions of MAZ
  • FOXF2 directly bound the promoter of E3 ligase interferon regulatory factor 2-binding protein-like (IRF2BPL) and induced its transcriptional expression
  • FOXF2 inhibited WNT signaling by inducing CTNNB1 protein ubiquitination and degradation independently of GSK3B
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    was silenced in gastric cancer cell lines and cancer tissues by promoter methylation, which was negatively associated with mRNA expression
    tumoral     --low  
    indicates the early-onset metastasis and poor prognosis for patients with histological grade II and triple-negative breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • interesting candidate locus for stroke susceptibility
    • Marker
  • MAZ mRNA level, particularly in combination with the FOXF2 mRNA level, may serve as a prognostic marker for basal-like breast cancer (BLBC) patients
  • FOXF2 methylation might be a useful prognostic biomarker for esophageal squamous cell carcinoma patients
  • decreased FOXF2 expression is an independent predictive factor for poor prognosis of patients with non-small cell lung cancer (NSCLC), especially in stage I NSCLC
    • Therapy target
    ANIMAL & CELL MODELS
  • Foxf2(-/-) mice are perinatal lethal with multiple malformations
  • Foxf2 knockout mice present with cleft palate in combination with hypoplasia of the genital tubercle