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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

HDAC3

contributors: mct/ - updated : 10-04-2019

HGNC name	histone deacetylase 3
HGNC id	4854

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in squamous cell lung carcinomas

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed blood     HDAC3 inhibitors are being considered as promising candidates for cancer therapy blood     promising target for therapies aiming to expand hematopoietic stem cells neurology neurodegenerative   HDAC3 inhibitors being tested for relief of expansion-associated gene silencing may also suppress somatic expansions that contribute to disease progression allergy     HDAC3 serves as a target for development of allergy therapeutics.

ANIMAL & CELL MODELS

deletion of Hdac3 or Nr1d1 in mouse liver causes hepatic steatosis