| 1 | FOXK1, HDAC3, STAT1, STAT2
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| Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription.
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| Yang L, Chen S, Zhao Q, Pan C, Peng L, Han Y, Li L, Ruan J, Xia J, Yang H, Xu F, Cheng G.
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| Cell Rep. Jan 25;38(4):110302. doi: 10.1016/j.celrep.2022 2022
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| 2 | EMD, HDAC3
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| Histone acetyltransferase inhibition rescues differentiation of emerin-deficient myogenic progenitors.
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| Bossone KA, Ellis JA, Holaska JM.
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| Muscle Nerve uscle Nerve. 2020 Apr 18. doi: 10.1002/mus.26892. [Epub ahead of print]
2020
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| 3 | HDAC3, NKAP
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| The Interaction between NKAP and HDAC3 Is Critical for T Cell Maturation.
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| Dash B, Shapiro MJ, Thapa P, Romero Arocha S, Chung JY, Schwab AD, McCue SA, Rajcula MJ, Shapiro VS.
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| Immunohorizons 3(8):352-367. doi: 10.4049/immunohorizons.1900052.
2019
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| 4 | HDAC3, NKAP
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| NKAP Must Associate with HDAC3 to Regulate Hematopoietic Stem Cell Maintenance and Survival.
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| Shapiro MJ, Lehrke MJ, Chung JY, Romero Arocha S, Shapiro VS.
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| J Immunol 202(8):2287-2295. doi: 10.4049/jimmunol.1800862. Epub 2019 Feb 25.
2019
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| 5 | AKT1, HDAC3, PDCD5
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| Programmed cell death 5 suppresses AKT-mediated cytoprotection of endothelium.
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| Lee SH, Seo J, Park SY, Jeong MH, Choi HK, Lee CJ, Kim MJ, Guk G, Lee S, Park H, Jeong JW, Ha CH, Park S, Yoon HG.
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| Proc Natl Acad Sci U S A 115(18):4672-4677. doi: 10.1073/pnas.1712918115. Epub 2018 Mar 27.
2018
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| 6 | ACTL6B, HDAC3
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| Deleting HDAC3 rescues long-term memory impairments induced by disruption of the neuron-specific chromatin remodeling subunit BAF53b.
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| Shu G, Kramár EA, López AJ, Huynh G, Wood MA, Kwapis JL.
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| Learn Mem 25(3):109-114. doi: 10.1101/lm.046920.117. Print 2018 Mar.
2018
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| 7 | HDAC3, PDCD5
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| Programmed cell death 5 mediates HDAC3 decay to promote genotoxic stress response.
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| Choi HK, Choi Y, Park ES, Park SY, Lee SH, Seo J, Jeong MH, Jeong JW, Jeong JH, Lee PC, Choi KC, Yoon HG.
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| Nat Commun 6:7390. doi: 10.1038/ncomms8390. Erratum in: Nat Commun. 2015;6:8225. Jeong, Jae-Ho [Corrected to Cheong, Jae-Ho].
2015
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| 8 | HDAC3, MPL, RBM15, SETD1B
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| Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl.
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| Xiao N, Laha S, Das SP, Morlock K, Jesneck JL, Raffel GD.
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| Blood Feb 5;125(6):941-8. doi: 10.1182/blood-2014-08-593392. Epub 2014 Dec 2. 2015
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| 9 | HDAC3, NCOR2
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| Activation of p53 transcriptional activity by SMRT: a histone deacetylase 3-independent function of a transcriptional corepressor.
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| Adikesavan AK, Karmakar S, Pardo P, Wang L, Liu S, Li W, Smith CL.
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| Mol Cell Biol 34(7):1246-61. doi: 10.1128/MCB.01216-13. Epub 2014 Jan 21.
2014
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| 10 | HDAC3, TBX5
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| Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis.
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| Lewandowski SL, Janardhan HP, Smee KM, Bachman M, Sun Z, Lazar MA, Trivedi CM.
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| Hum Mol Genet 23(14):3801-9. doi: 10.1093/hmg/ddu093. Epub 2014 Feb 23.
2014
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| 11 | HDAC3
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| Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo.
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| You SH, Lim HW, Sun Z, Broache M, Won KJ, Lazar MA.
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| Nat Struct Mol Biol 20(2):182-7. doi: 10.1038/nsmb.2476. Epub 2013 Jan 6.
2013
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| 12 | HDAC3
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| Histone deacetylase 3 is required for maintenance of bone mass during aging.
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| McGee-Lawrence ME, Bradley EW, Dudakovic A, Carlson SW, Ryan ZC, Kumar R, Dadsetan M, Yaszemski MJ, Chen Q, An KN, Westendorf JJ.
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| Bone 52(1):296-307. doi: 10.1016/j.bone.2012.10.015. Epub 2012 Oct 18. Erratum in: Bone. 2013 Mar;53(1):320.
2013
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| 13 | ESR1, HDAC3
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| HDAC3 regulates stability of estrogen receptor α mRNA.
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| Oie S, Matsuzaki K, Yokoyama W, Murayama A, Yanagisawa J.
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| Biochem Biophys Res Commun 432(2):236-41. doi: 10.1016/j.bbrc.2013.02.007. Epub 2013 Feb 10.
2013
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| 14 | HDAC3, NCOR2
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| Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor.
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| Sun Z, Feng D, Fang B, Mullican SE, You SH, Lim HW, Everett LJ, Nabel CS, Li Y, Selvakumaran V, Won KJ, Lazar MA.
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| Mol Cell 52(6):769-82. doi: 10.1016/j.molcel.2013.10.022. Epub 2013 Nov 21.
2013
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| 15 | AXIN2, HDAC3, RUNX2
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| Runx2 protein represses Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-deficient mice.
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| McGee-Lawrence ME, Li X, Bledsoe KL, Wu H, Hawse JR, Subramaniam M, Razidlo DF, Stensgard BA, Stein GS, van Wijnen AJ, Lian JB, Hsu W, Westendorf JJ.
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| J Biol Chem 288(8):5291-302. doi: 10.1074/jbc.M112.414995. Epub 2013 Jan 7.
2013
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| 16 | ATXN7, HDAC3
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| Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model.
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| Duncan CE, An MC, Papanikolaou T, Rugani C, Vitelli C, Ellerby LM.
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| Mol Neurodegener 8:42. doi: 10.1186/1750-1326-8-42.
2013
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| 17 | HDAC3, KAT8, MSH4
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| DNA damage induced MutS homologue hMSH4 acetylation.
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| Chu YL, Wu X, Xu J, Watts JL, Her C.
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| Int J Mol Sci. Oct 18;14(10):20966-82. doi: 10.3390/ijms141020966 2013
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| 18 | CCNA2, HDAC3, KAT2A, KAT2B
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| Histone deacetylase 3 regulates cyclin A stability.
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| Vidal-Laliena M, Gallastegui E, Mateo F, Martínez-Balbás M, Pujol MJ, Bachs O.
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| J Biol Chem. Jul 19;288(29):21096-21104. doi: 10.1074/jbc.M113.458323. Epub 2013 Jun 11. 2013
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| 19 | HDAC3
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| Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages.
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| Chen X, Barozzi I, Termanini A, Prosperini E, Recchiuti A, Dalli J, Mietton F, Matteoli G, Hiebert S, Natoli G.
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| Proc Natl Acad Sci U S A 109(42):E2865-74. doi: 10.1073/pnas.1121131109. Epub 2012 Jul 16.
2012
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| 20 | EMD, HDAC3
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| The nuclear envelope protein emerin binds directly to histone deacetylase 3 (HDAC3) and activates HDAC3 activity.
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| Demmerle J, Koch AJ, Holaska JM.
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| J Biol Chem 287(26):22080-8. doi: 10.1074/jbc.M111.325308. Epub 2012 May 8.
2012
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| 21 | HDAC3
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| Histone deacetylase 3 modulates the expansion of human hematopoietic stem cells.
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| Elizalde C, Fernández-Rueda J, Salcedo JM, Dorronsoro A, Ferrin I, Jakobsson E, Trigueros C.
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| Stem Cells Dev 21(14):2581-91. doi: 10.1089/scd.2011.0698. Epub 2012 May 8.
2012
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| 22 | HDAC3
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| Histone deacetylase complexes promote trinucleotide repeat expansions.
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| Debacker K, Frizzell A, Gleeson O, Kirkham-McCarthy L, Mertz T, Lahue RS.
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| PLoS Biol 10(2):e1001257. doi: 10.1371/journal.pbio.1001257. Epub 2012 Feb 21.
2012
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| 23 | HDAC3
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| Regulated clearance of histone deacetylase 3 protects independent formation of nuclear receptor corepressor complexes.
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| Guo C, Gow CH, Li Y, Gardner A, Khan S, Zhang J.
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| J Biol Chem 287(15):12111-20. doi: 10.1074/jbc.M111.327023. Epub 2012 Feb 15.
2012
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| 24 | HDAC3
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| Structure of HDAC3 bound to co-repressor and inositol tetraphosphate.
|
| Watson PJ, Fairall L, Santos GM, Schwabe JW.
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| Nature 481(7381):335-40. doi: 10.1038/nature10728.
2012
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| 25 | ETV6, HDAC3, IRF8, PDGFRB, PTPN13
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| The leukemia-associated fusion protein Tel-platelet-derived growth factor receptor β (Tel-PdgfRβ) inhibits transcriptional repression of PTPN13 gene by interferon consensus sequence binding protein (Icsbp).
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| Huang W, Hu L, Bei L, Hjort E, Eklund EA.
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| J Biol Chem 287(11):8110-25. doi: 10.1074/jbc.M111.294884. Epub 2012 Jan 18.
2012
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| 26 | HDAC3, IL10, IL12B
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| IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis.
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| Kobayashi T, Matsuoka K, Sheikh SZ, Russo SM, Mishima Y, Collins C, deZoeten EF, Karp CL, Ting JP, Sartor RB, Plevy SE.
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| J Immunol 189(4):1792-9. doi: 10.4049/jimmunol.1200042. Epub 2012 Jul 11.
2012
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| 27 | HDAC3, NCOR2
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| Regulated clearance of histone deacetylase 3 protects independent formation of nuclear receptor corepressor complexes.
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| Guo C, Gow CH, Li Y, Gardner A, Khan S, Zhang J.
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| J Biol Chem 287(15):12111-20. doi: 10.1074/jbc.M111.327023. Epub 2012 Feb 15.
2012
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| 28 | CCL2, HDAC2, HDAC3, MS4A2
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| Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.
|
| Kim Y, Kim K, Park D, Lee E, Lee H, Lee YS, Choe J, Jeoung D.
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| J Biol Chem 287(31):25844-59. doi: 10.1074/jbc.M112.348284. Epub 2012 Jun 7.
2012
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| 29 | ATF3, HDAC3, HDAC6, JDP2
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| The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter.
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| Darlyuk-Saadon I, Weidenfeld-Baranboim K, Yokoyama KK, Hai T, Aronheim A.
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| Biochim Biophys Acta 1819(11-12):1142-53. doi: 10.1016/j.bbagrm.2012.09.005. Epub 2012 Sep 16.
2012
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| 30 | HDAC3
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| HDAC3 is a critical negative regulator of long-term memory formation.
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| McQuown SC, Barrett RM, Matheos DP, Post RJ, Rogge GA, Alenghat T, Mullican SE, Jones S, Rusche JR, Lazar MA, Wood MA.
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| J Neurosci 31(2):764-74.
2011
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| 31 | GPS2, HDAC3, NCOR, NCOR2, TBL1X
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| Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery.
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| Oberoi J, Fairall L, Watson PJ, Yang JC, Czimmerer Z, Kampmann T, Goult BT, Greenwood JA, Gooch JT, Kallenberger BC, Nagy L, Neuhaus D, Schwabe JW.
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| Nat Struct Mol Biol 18(2):177-84. Epub 2011 Jan 16. 2011
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| 32 | HDAC3, NR1D1
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| A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism.
|
| Feng D, Liu T, Sun Z, Bugge A, Mullican SE, Alenghat T, Liu XS, Lazar MA.
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| Science 331(6022):1315-9.
2011
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| 33 | HDAC3, HDAC7, MITF
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| HDAC3 and HDAC7 have opposite effects on osteoclast differentiation.
|
| Pham L, Kaiser B, Romsa A, Schwarz T, Gopalakrishnan R, Jensen ED, Mansky KC.
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| J Biol Chem 286(14):12056-65. Epub 2011 Feb 15.
2011
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| 34 | HDAC3
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| HDAC3 at the fulcrum of an epithelial-mesenchymal balance.
|
| Mani SA, Barton MC.
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| Mol Cell 43(5):697-8.
2011
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| 35 | HDAC3, WDR5
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| Interplay between HDAC3 and WDR5 is essential for hypoxia-induced epithelial-mesenchymal transition.
|
| Wu MZ, Tsai YP, Yang MH, Huang CH, Chang SY, Chang CC, Teng SC, Wu KJ.
|
| Mol Cell 43(5):811-22.
2011
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| 36 | HDAC3
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| Histone deacetylase 3 regulates smooth muscle differentiation in neural crest cells and development of the cardiac outflow tract.
|
| Singh N, Trivedi CM, Lu M, Mullican SE, Lazar MA, Epstein JA.
|
| Circ Res 109(11):1240-9. doi: 10.1161/CIRCRESAHA.111.255067. Epub 2011 Sep 29.
2011
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| 37 | HDAC3, L3MBTL2
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| Histone deacetylase 3 is selectively involved in L3MBTL2-mediated transcriptional repression.
|
| Yoo JY, Choi KC, Kang H, Kim YJ, Lee J, Jun WJ, Kim MJ, Lee YH, Lee OH, Yoon HG.
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| FEBS Lett 584(11):2225-30. Epub 2010 Apr 10.PMID: 20385135 2010
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| 38 | CREB3, HDAC3
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| HDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells.
|
| Kim HC, Choi KC, Choi HK, Kang HB, Kim MJ, Lee YH, Lee OH, Lee J, Kim YJ, Jun W, Jeong JW, Yoon HG.
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| Cell Mol Life Sci 67(20):3499-510. Epub 2010 May 15.PMID: 20473547 2010
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| 39 | HDAC3, SIAH2, SKI
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| The Ski protein negatively regulates Siah2-mediated HDAC3 degradation.
|
| Zhao HL, Ueki N, Hayman MJ.
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| Biochem Biophys Res Commun 399(4):623-8. Epub 2010 Aug 4.
2010
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| 40 | CCAR2, HDAC3
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| HDAC3 is negatively regulated by the nuclear protein DBC1.
|
| Chini CC, Escande C, Nin V, Chini EN.
|
| J Biol Chem 285(52):40830-7. Epub 2010 Oct 28. 2010
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| 41 | HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9
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| The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men.
|
| Yang XJ, Seto E.
|
| Nat Rev Mol Cell Biol 9(3):206-18. Review.
2008
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| 42 | HDAC1, HDAC3, NIPBL
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| The Cohesin loading factor NIPBL recruits histone deacetylases to mediate local chromatin modifications.
|
| Jahnke P, Xu W, Wülling M, Albrecht M, Gabriel H, Gillessen-Kaesbach G, Kaiser FJ.
|
| Nucleic Acids Res 36(20):6450-8. Epub 2008 Oct 14.
2008
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| 43 | HDAC3, NCOR1
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| Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology.
|
| Alenghat T, Meyers K, Mullican SE, Leitner K, Adeniji-Adele A, Avila J, Bućan M, Ahima RS, Kaestner KH, Lazar MA.
|
| Nature 456(7224):997-1000. Epub 2008 Nov 26.
2008
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| 44 | HDAC3
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| HDAC3 overexpression and colon cancer cell proliferation and differentiation.
|
| Spurling CC, Godman CA, Noonan EJ, Rasmussen TP, Rosenberg DW, Giardina C.
|
| Mol Carcinog 47(2):137-47.PMID: 17849419 2008
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| 45 | HDAC3
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| Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control.
|
| Bhaskara S, Chyla BJ, Amann JM, Knutson SK, Cortez D, Sun ZW, Hiebert SW.
|
| Mol Cell 30(1):61-72.PMID: 18406327 2008
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| 46 | HDAC3, LSS
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| Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression.
|
| Villagra A, Ulloa N, Zhang X, Yuan Z, Sotomayor E, Seto E.
|
| J Biol Chem 282(49):35457-70. Epub 2007 Oct 9. 2007
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| 47 | MBD1, HDAC3
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| The methyl-CpG binding protein MBD1 is required for PML-RARalpha function.
|
| Villa R, Morey L, Raker VA, Buschbeck M, Gutierrez A, De Santis F, Corsaro M, Varas F, Bossi D, Minucci S, Pelicci PG, Di Croce L.
|
| Proc Natl Acad Sci U S A 103(5):1400-5. Epub 2006 Jan 23. 2006
|
| 48 | HDAC3
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| Comparative application of antibody and gene array for expression profiling in human squamous cell lung carcinoma.
|
| Bartling B, Hofmann HS, Boettger T, Hansen G, Burdach S, Silber RE, Simm A.
|
| Lung Cancer 49(2):145-54. 2005
|
| 49 | THAP7, NCOR1, HDAC3
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| Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor.
|
| Macfarlan T, Kutney S, Altman B, Montross R, Yu J, Chakravarti D.
|
| J Biol Chem 280(8):7346-58. Epub 2004 Nov 23. 2005
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| 50 | HDAC3, KLF6, DLK1
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| Kruppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1.
|
| Li D, Yea S, Li S, Chen Z, Narla G, Banck M, Laborda J, Tan S, Friedman JM, Friedman SL, Walsh MJ.
|
| J Biol Chem 280(29):26941-52. Epub 2005 May 25. 2005
|
| 51 | HDAC3, HDAC4, HDAC5, NCOR1, NCOR2
|
| Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.
|
| Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E.
|
| Mol Cell 9(1):45-57. 2002
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| 52 | HDAC3
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| The histone deacetylase-3 complex contains nuclear receptor corepressors.
|
| Wen YD, Perissi V, Staszewski LM, Yang WM, Krones A, Glass CK, Rosenfeld MG, Seto E.
|
| Proc Natl Acad Sci U S A 97(13):7202-7. 2000
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| 53 | HDAC3, NCOR, NCOR2, TBL1X
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| Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3.
|
| Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J.
|
| EMBO J 19(16):4342-50.
2000
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| 54 | HDAC3
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| Genomic Organization and Chromosomal Localization of the Human Histone Deacetylase 3 Gene.
|
| Mahlknecht U, et al.
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| Genomics 56(2):197-202. 1999
|
| 55 | HDAC3
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| High resolution physical mapping of human HDAC3, a potential tumor suppressor gene in the 5q31 region.
|
| Mahlknecht U, et al.
|
| Cytogenet Cell Genet 86(3-4):237-239 1999
|
| 56 | HDAC1, HDAC2, HDAC3, KAT2A, KAT2B
|
| Identification and mapping of human histone acetylation modifier gene homologues.
|
| Randhawa GS, et al.
|
| Genomics 51 : 262-269. 1998
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| 57 | HDAC3
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| Characterization of a human RPD3 ortholog, HDAC3.
|
| Emiliani S, et al.
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| Proc Natl Acad Sci U S A 95(6):2795-800. 1998
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| 58 | HDAC3
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| Isolation and characterization of cDNAs corresponding to an additonal member of the human histone deacetylase gene family.
|
| Yang WM, et al.
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| J Biol Chem 272 : 28001-28007. 1997
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| 59 | HDAC2, HDAC3, YY1
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| Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3.
|
| Yang WM, et al.
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| Proc Natl Acad Sci U S A 93 : 12845-12850. 1996
|