| 1 | HDAC3, IDEMS
|
| De novo missense variants in HDAC3 leading to epigenetic machinery dysfunction are associated with a variable neurodevelopmental disorder.
|
| Yoon JG, Lim SK, Seo H, Lee S, Cho J, Kim SY, Koh HY, Poduri AH, Ramakumaran V, Vasudevan P, de Groot MJ, Ko JM, Han D, Chae JH, Lee CH.
|
| Am J Hum Genet. Aug 8;111(8):1588-1604. doi: 10.1016/j.ajhg.2024.06.015. Epub 2024 Jul 23. 2024
|
| 2 | FOXK1, HDAC3, STAT1, STAT2
|
| Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription.
|
| Yang L, Chen S, Zhao Q, Pan C, Peng L, Han Y, Li L, Ruan J, Xia J, Yang H, Xu F, Cheng G.
|
| Cell Rep. Jan 25;38(4):110302. doi: 10.1016/j.celrep.2022 2022
|
| 3 | EMD, HDAC3
|
| Histone acetyltransferase inhibition rescues differentiation of emerin-deficient myogenic progenitors.
|
| Bossone KA, Ellis JA, Holaska JM.
|
| Muscle Nerve uscle Nerve. 2020 Apr 18. doi: 10.1002/mus.26892. [Epub ahead of print]
2020
|
| 4 | HDAC3, NKAP
|
| The Interaction between NKAP and HDAC3 Is Critical for T Cell Maturation.
|
| Dash B, Shapiro MJ, Thapa P, Romero Arocha S, Chung JY, Schwab AD, McCue SA, Rajcula MJ, Shapiro VS.
|
| Immunohorizons 3(8):352-367. doi: 10.4049/immunohorizons.1900052.
2019
|
| 5 | HDAC3, NKAP
|
| NKAP Must Associate with HDAC3 to Regulate Hematopoietic Stem Cell Maintenance and Survival.
|
| Shapiro MJ, Lehrke MJ, Chung JY, Romero Arocha S, Shapiro VS.
|
| J Immunol 202(8):2287-2295. doi: 10.4049/jimmunol.1800862. Epub 2019 Feb 25.
2019
|
| 6 | AKT1, HDAC3, PDCD5
|
| Programmed cell death 5 suppresses AKT-mediated cytoprotection of endothelium.
|
| Lee SH, Seo J, Park SY, Jeong MH, Choi HK, Lee CJ, Kim MJ, Guk G, Lee S, Park H, Jeong JW, Ha CH, Park S, Yoon HG.
|
| Proc Natl Acad Sci U S A 115(18):4672-4677. doi: 10.1073/pnas.1712918115. Epub 2018 Mar 27.
2018
|
| 7 | ACTL6B, HDAC3
|
| Deleting HDAC3 rescues long-term memory impairments induced by disruption of the neuron-specific chromatin remodeling subunit BAF53b.
|
| Shu G, Kramár EA, López AJ, Huynh G, Wood MA, Kwapis JL.
|
| Learn Mem 25(3):109-114. doi: 10.1101/lm.046920.117. Print 2018 Mar.
2018
|
| 8 | DDX53, EGFR, HDAC3
|
| Histone Deacetylase-3/CAGE Axis Targets EGFR Signaling and Regulates the Response to Anti-Cancer Drugs
|
| Kim H, Kim Y, Goh H, Jeoung D.
|
| Mol Cells. Mar;39(3):229-41. doi: 10.14348/molcells.2016.2244. Epub 2016 Feb 16. 2016
|
| 9 | HDAC3, PDCD5
|
| Programmed cell death 5 mediates HDAC3 decay to promote genotoxic stress response.
|
| Choi HK, Choi Y, Park ES, Park SY, Lee SH, Seo J, Jeong MH, Jeong JW, Jeong JH, Lee PC, Choi KC, Yoon HG.
|
| Nat Commun 6:7390. doi: 10.1038/ncomms8390. Erratum in: Nat Commun. 2015;6:8225. Jeong, Jae-Ho [Corrected to Cheong, Jae-Ho].
2015
|
| 10 | HDAC3, MPL, RBM15, SETD1B
|
| Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl.
|
| Xiao N, Laha S, Das SP, Morlock K, Jesneck JL, Raffel GD.
|
| Blood Feb 5;125(6):941-8. doi: 10.1182/blood-2014-08-593392. Epub 2014 Dec 2. 2015
|
| 11 | HDAC3, NCOR2
|
| Activation of p53 transcriptional activity by SMRT: a histone deacetylase 3-independent function of a transcriptional corepressor.
|
| Adikesavan AK, Karmakar S, Pardo P, Wang L, Liu S, Li W, Smith CL.
|
| Mol Cell Biol 34(7):1246-61. doi: 10.1128/MCB.01216-13. Epub 2014 Jan 21.
2014
|
| 12 | HDAC3, TBX5
|
| Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis.
|
| Lewandowski SL, Janardhan HP, Smee KM, Bachman M, Sun Z, Lazar MA, Trivedi CM.
|
| Hum Mol Genet 23(14):3801-9. doi: 10.1093/hmg/ddu093. Epub 2014 Feb 23.
2014
|
| 13 | HDAC3
|
| Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo.
|
| You SH, Lim HW, Sun Z, Broache M, Won KJ, Lazar MA.
|
| Nat Struct Mol Biol 20(2):182-7. doi: 10.1038/nsmb.2476. Epub 2013 Jan 6.
2013
|
| 14 | HDAC3
|
| Histone deacetylase 3 is required for maintenance of bone mass during aging.
|
| McGee-Lawrence ME, Bradley EW, Dudakovic A, Carlson SW, Ryan ZC, Kumar R, Dadsetan M, Yaszemski MJ, Chen Q, An KN, Westendorf JJ.
|
| Bone 52(1):296-307. doi: 10.1016/j.bone.2012.10.015. Epub 2012 Oct 18. Erratum in: Bone. 2013 Mar;53(1):320.
2013
|
| 15 | ESR1, HDAC3
|
| HDAC3 regulates stability of estrogen receptor α mRNA.
|
| Oie S, Matsuzaki K, Yokoyama W, Murayama A, Yanagisawa J.
|
| Biochem Biophys Res Commun 432(2):236-41. doi: 10.1016/j.bbrc.2013.02.007. Epub 2013 Feb 10.
2013
|
| 16 | HDAC3, NCOR2
|
| Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor.
|
| Sun Z, Feng D, Fang B, Mullican SE, You SH, Lim HW, Everett LJ, Nabel CS, Li Y, Selvakumaran V, Won KJ, Lazar MA.
|
| Mol Cell 52(6):769-82. doi: 10.1016/j.molcel.2013.10.022. Epub 2013 Nov 21.
2013
|
| 17 | AXIN2, HDAC3, RUNX2
|
| Runx2 protein represses Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-deficient mice.
|
| McGee-Lawrence ME, Li X, Bledsoe KL, Wu H, Hawse JR, Subramaniam M, Razidlo DF, Stensgard BA, Stein GS, van Wijnen AJ, Lian JB, Hsu W, Westendorf JJ.
|
| J Biol Chem 288(8):5291-302. doi: 10.1074/jbc.M112.414995. Epub 2013 Jan 7.
2013
|
| 18 | ATXN7, HDAC3
|
| Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model.
|
| Duncan CE, An MC, Papanikolaou T, Rugani C, Vitelli C, Ellerby LM.
|
| Mol Neurodegener 8:42. doi: 10.1186/1750-1326-8-42.
2013
|
| 19 | HDAC3, KAT8, MSH4
|
| DNA damage induced MutS homologue hMSH4 acetylation.
|
| Chu YL, Wu X, Xu J, Watts JL, Her C.
|
| Int J Mol Sci. Oct 18;14(10):20966-82. doi: 10.3390/ijms141020966 2013
|
| 20 | CCNA2, HDAC3, KAT2A, KAT2B
|
| Histone deacetylase 3 regulates cyclin A stability.
|
| Vidal-Laliena M, Gallastegui E, Mateo F, Martínez-Balbás M, Pujol MJ, Bachs O.
|
| J Biol Chem. Jul 19;288(29):21096-21104. doi: 10.1074/jbc.M113.458323. Epub 2013 Jun 11. 2013
|
| 21 | HDAC3
|
| Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages.
|
| Chen X, Barozzi I, Termanini A, Prosperini E, Recchiuti A, Dalli J, Mietton F, Matteoli G, Hiebert S, Natoli G.
|
| Proc Natl Acad Sci U S A 109(42):E2865-74. doi: 10.1073/pnas.1121131109. Epub 2012 Jul 16.
2012
|
| 22 | EMD, HDAC3
|
| The nuclear envelope protein emerin binds directly to histone deacetylase 3 (HDAC3) and activates HDAC3 activity.
|
| Demmerle J, Koch AJ, Holaska JM.
|
| J Biol Chem 287(26):22080-8. doi: 10.1074/jbc.M111.325308. Epub 2012 May 8.
2012
|
| 23 | HDAC3
|
| Histone deacetylase 3 modulates the expansion of human hematopoietic stem cells.
|
| Elizalde C, Fernández-Rueda J, Salcedo JM, Dorronsoro A, Ferrin I, Jakobsson E, Trigueros C.
|
| Stem Cells Dev 21(14):2581-91. doi: 10.1089/scd.2011.0698. Epub 2012 May 8.
2012
|
| 24 | HDAC3
|
| Histone deacetylase complexes promote trinucleotide repeat expansions.
|
| Debacker K, Frizzell A, Gleeson O, Kirkham-McCarthy L, Mertz T, Lahue RS.
|
| PLoS Biol 10(2):e1001257. doi: 10.1371/journal.pbio.1001257. Epub 2012 Feb 21.
2012
|
| 25 | HDAC3
|
| Regulated clearance of histone deacetylase 3 protects independent formation of nuclear receptor corepressor complexes.
|
| Guo C, Gow CH, Li Y, Gardner A, Khan S, Zhang J.
|
| J Biol Chem 287(15):12111-20. doi: 10.1074/jbc.M111.327023. Epub 2012 Feb 15.
2012
|
| 26 | HDAC3
|
| Structure of HDAC3 bound to co-repressor and inositol tetraphosphate.
|
| Watson PJ, Fairall L, Santos GM, Schwabe JW.
|
| Nature 481(7381):335-40. doi: 10.1038/nature10728.
2012
|
| 27 | ETV6, HDAC3, IRF8, PDGFRB, PTPN13
|
| The leukemia-associated fusion protein Tel-platelet-derived growth factor receptor β (Tel-PdgfRβ) inhibits transcriptional repression of PTPN13 gene by interferon consensus sequence binding protein (Icsbp).
|
| Huang W, Hu L, Bei L, Hjort E, Eklund EA.
|
| J Biol Chem 287(11):8110-25. doi: 10.1074/jbc.M111.294884. Epub 2012 Jan 18.
2012
|
| 28 | HDAC3, IL10, IL12B
|
| IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis.
|
| Kobayashi T, Matsuoka K, Sheikh SZ, Russo SM, Mishima Y, Collins C, deZoeten EF, Karp CL, Ting JP, Sartor RB, Plevy SE.
|
| J Immunol 189(4):1792-9. doi: 10.4049/jimmunol.1200042. Epub 2012 Jul 11.
2012
|
| 29 | HDAC3, NCOR2
|
| Regulated clearance of histone deacetylase 3 protects independent formation of nuclear receptor corepressor complexes.
|
| Guo C, Gow CH, Li Y, Gardner A, Khan S, Zhang J.
|
| J Biol Chem 287(15):12111-20. doi: 10.1074/jbc.M111.327023. Epub 2012 Feb 15.
2012
|
| 30 | CCL2, HDAC2, HDAC3, MS4A2
|
| Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.
|
| Kim Y, Kim K, Park D, Lee E, Lee H, Lee YS, Choe J, Jeoung D.
|
| J Biol Chem 287(31):25844-59. doi: 10.1074/jbc.M112.348284. Epub 2012 Jun 7.
2012
|
| 31 | ATF3, HDAC3, HDAC6, JDP2
|
| The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter.
|
| Darlyuk-Saadon I, Weidenfeld-Baranboim K, Yokoyama KK, Hai T, Aronheim A.
|
| Biochim Biophys Acta 1819(11-12):1142-53. doi: 10.1016/j.bbagrm.2012.09.005. Epub 2012 Sep 16.
2012
|
| 32 | HDAC3
|
| HDAC3 is a critical negative regulator of long-term memory formation.
|
| McQuown SC, Barrett RM, Matheos DP, Post RJ, Rogge GA, Alenghat T, Mullican SE, Jones S, Rusche JR, Lazar MA, Wood MA.
|
| J Neurosci 31(2):764-74.
2011
|
| 33 | GPS2, HDAC3, NCOR, NCOR2, TBL1X
|
| Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery.
|
| Oberoi J, Fairall L, Watson PJ, Yang JC, Czimmerer Z, Kampmann T, Goult BT, Greenwood JA, Gooch JT, Kallenberger BC, Nagy L, Neuhaus D, Schwabe JW.
|
| Nat Struct Mol Biol 18(2):177-84. Epub 2011 Jan 16. 2011
|
| 34 | HDAC3, NR1D1
|
| A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism.
|
| Feng D, Liu T, Sun Z, Bugge A, Mullican SE, Alenghat T, Liu XS, Lazar MA.
|
| Science 331(6022):1315-9.
2011
|
| 35 | HDAC3, HDAC7, MITF
|
| HDAC3 and HDAC7 have opposite effects on osteoclast differentiation.
|
| Pham L, Kaiser B, Romsa A, Schwarz T, Gopalakrishnan R, Jensen ED, Mansky KC.
|
| J Biol Chem 286(14):12056-65. Epub 2011 Feb 15.
2011
|
| 36 | HDAC3
|
| HDAC3 at the fulcrum of an epithelial-mesenchymal balance.
|
| Mani SA, Barton MC.
|
| Mol Cell 43(5):697-8.
2011
|
| 37 | HDAC3, WDR5
|
| Interplay between HDAC3 and WDR5 is essential for hypoxia-induced epithelial-mesenchymal transition.
|
| Wu MZ, Tsai YP, Yang MH, Huang CH, Chang SY, Chang CC, Teng SC, Wu KJ.
|
| Mol Cell 43(5):811-22.
2011
|
| 38 | HDAC3
|
| Histone deacetylase 3 regulates smooth muscle differentiation in neural crest cells and development of the cardiac outflow tract.
|
| Singh N, Trivedi CM, Lu M, Mullican SE, Lazar MA, Epstein JA.
|
| Circ Res 109(11):1240-9. doi: 10.1161/CIRCRESAHA.111.255067. Epub 2011 Sep 29.
2011
|
| 39 | HDAC3, L3MBTL2
|
| Histone deacetylase 3 is selectively involved in L3MBTL2-mediated transcriptional repression.
|
| Yoo JY, Choi KC, Kang H, Kim YJ, Lee J, Jun WJ, Kim MJ, Lee YH, Lee OH, Yoon HG.
|
| FEBS Lett 584(11):2225-30. Epub 2010 Apr 10.PMID: 20385135 2010
|
| 40 | CREB3, HDAC3
|
| HDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells.
|
| Kim HC, Choi KC, Choi HK, Kang HB, Kim MJ, Lee YH, Lee OH, Lee J, Kim YJ, Jun W, Jeong JW, Yoon HG.
|
| Cell Mol Life Sci 67(20):3499-510. Epub 2010 May 15.PMID: 20473547 2010
|
| 41 | HDAC3, SIAH2, SKI
|
| The Ski protein negatively regulates Siah2-mediated HDAC3 degradation.
|
| Zhao HL, Ueki N, Hayman MJ.
|
| Biochem Biophys Res Commun 399(4):623-8. Epub 2010 Aug 4.
2010
|
| 42 | CCAR2, HDAC3
|
| HDAC3 is negatively regulated by the nuclear protein DBC1.
|
| Chini CC, Escande C, Nin V, Chini EN.
|
| J Biol Chem 285(52):40830-7. Epub 2010 Oct 28. 2010
|
| 43 | HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9
|
| The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men.
|
| Yang XJ, Seto E.
|
| Nat Rev Mol Cell Biol 9(3):206-18. Review.
2008
|
| 44 | HDAC1, HDAC3, NIPBL
|
| The Cohesin loading factor NIPBL recruits histone deacetylases to mediate local chromatin modifications.
|
| Jahnke P, Xu W, Wülling M, Albrecht M, Gabriel H, Gillessen-Kaesbach G, Kaiser FJ.
|
| Nucleic Acids Res 36(20):6450-8. Epub 2008 Oct 14.
2008
|
| 45 | HDAC3, NCOR1
|
| Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology.
|
| Alenghat T, Meyers K, Mullican SE, Leitner K, Adeniji-Adele A, Avila J, Buæan M, Ahima RS, Kaestner KH, Lazar MA.
|
| Nature 456(7224):997-1000. Epub 2008 Nov 26.
2008
|
| 46 | HDAC3
|
| HDAC3 overexpression and colon cancer cell proliferation and differentiation.
|
| Spurling CC, Godman CA, Noonan EJ, Rasmussen TP, Rosenberg DW, Giardina C.
|
| Mol Carcinog 47(2):137-47.PMID: 17849419 2008
|
| 47 | HDAC3
|
| Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control.
|
| Bhaskara S, Chyla BJ, Amann JM, Knutson SK, Cortez D, Sun ZW, Hiebert SW.
|
| Mol Cell 30(1):61-72.PMID: 18406327 2008
|
| 48 | HDAC3, LSS
|
| Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression.
|
| Villagra A, Ulloa N, Zhang X, Yuan Z, Sotomayor E, Seto E.
|
| J Biol Chem 282(49):35457-70. Epub 2007 Oct 9. 2007
|
| 49 | MBD1, HDAC3
|
| The methyl-CpG binding protein MBD1 is required for PML-RARalpha function.
|
| Villa R, Morey L, Raker VA, Buschbeck M, Gutierrez A, De Santis F, Corsaro M, Varas F, Bossi D, Minucci S, Pelicci PG, Di Croce L.
|
| Proc Natl Acad Sci U S A 103(5):1400-5. Epub 2006 Jan 23. 2006
|
| 50 | HDAC3
|
| Comparative application of antibody and gene array for expression profiling in human squamous cell lung carcinoma.
|
| Bartling B, Hofmann HS, Boettger T, Hansen G, Burdach S, Silber RE, Simm A.
|
| Lung Cancer 49(2):145-54. 2005
|
| 51 | THAP7, NCOR1, HDAC3
|
| Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor.
|
| Macfarlan T, Kutney S, Altman B, Montross R, Yu J, Chakravarti D.
|
| J Biol Chem 280(8):7346-58. Epub 2004 Nov 23. 2005
|
| 52 | HDAC3, KLF6, DLK1
|
| Kruppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1.
|
| Li D, Yea S, Li S, Chen Z, Narla G, Banck M, Laborda J, Tan S, Friedman JM, Friedman SL, Walsh MJ.
|
| J Biol Chem 280(29):26941-52. Epub 2005 May 25. 2005
|
| 53 | HDAC3, HDAC4, HDAC5, NCOR1, NCOR2
|
| Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.
|
| Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E.
|
| Mol Cell 9(1):45-57. 2002
|
| 54 | HDAC3
|
| The histone deacetylase-3 complex contains nuclear receptor corepressors.
|
| Wen YD, Perissi V, Staszewski LM, Yang WM, Krones A, Glass CK, Rosenfeld MG, Seto E.
|
| Proc Natl Acad Sci U S A 97(13):7202-7. 2000
|
| 55 | HDAC3, NCOR, NCOR2, TBL1X
|
| Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3.
|
| Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J.
|
| EMBO J 19(16):4342-50.
2000
|
| 56 | HDAC3
|
| Genomic Organization and Chromosomal Localization of the Human Histone Deacetylase 3 Gene.
|
| Mahlknecht U, et al.
|
| Genomics 56(2):197-202. 1999
|
| 57 | HDAC3
|
| High resolution physical mapping of human HDAC3, a potential tumor suppressor gene in the 5q31 region.
|
| Mahlknecht U, et al.
|
| Cytogenet Cell Genet 86(3-4):237-239 1999
|
| 58 | HDAC1, HDAC2, HDAC3, KAT2A, KAT2B
|
| Identification and mapping of human histone acetylation modifier gene homologues.
|
| Randhawa GS, et al.
|
| Genomics 51 : 262-269. 1998
|
| 59 | HDAC3
|
| Characterization of a human RPD3 ortholog, HDAC3.
|
| Emiliani S, et al.
|
| Proc Natl Acad Sci U S A 95(6):2795-800. 1998
|
| 60 | HDAC3
|
| Isolation and characterization of cDNAs corresponding to an additonal member of the human histone deacetylase gene family.
|
| Yang WM, et al.
|
| J Biol Chem 272 : 28001-28007. 1997
|
| 61 | HDAC2, HDAC3, YY1
|
| Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3.
|
| Yang WM, et al.
|
| Proc Natl Acad Sci U S A 93 : 12845-12850. 1996
|