Citations for
1EMD, HDAC3
Histone acetyltransferase inhibition rescues differentiation of emerin-deficient myogenic progenitors.
Bossone KA, Ellis JA, Holaska JM.
Muscle Nerve uscle Nerve. 2020 Apr 18. doi: 10.1002/mus.26892. [Epub ahead of print] 2020
2HDAC3, NKAP
The Interaction between NKAP and HDAC3 Is Critical for T Cell Maturation.
Dash B, Shapiro MJ, Thapa P, Romero Arocha S, Chung JY, Schwab AD, McCue SA, Rajcula MJ, Shapiro VS.
Immunohorizons 3(8):352-367. doi: 10.4049/immunohorizons.1900052. 2019
3HDAC3, NKAP
NKAP Must Associate with HDAC3 to Regulate Hematopoietic Stem Cell Maintenance and Survival.
Shapiro MJ, Lehrke MJ, Chung JY, Romero Arocha S, Shapiro VS.
J Immunol 202(8):2287-2295. doi: 10.4049/jimmunol.1800862. Epub 2019 Feb 25. 2019
4AKT1, HDAC3, PDCD5
Programmed cell death 5 suppresses AKT-mediated cytoprotection of endothelium.
Lee SH, Seo J, Park SY, Jeong MH, Choi HK, Lee CJ, Kim MJ, Guk G, Lee S, Park H, Jeong JW, Ha CH, Park S, Yoon HG.
Proc Natl Acad Sci U S A 115(18):4672-4677. doi: 10.1073/pnas.1712918115. Epub 2018 Mar 27. 2018
5ACTL6B, HDAC3
Deleting HDAC3 rescues long-term memory impairments induced by disruption of the neuron-specific chromatin remodeling subunit BAF53b.
Shu G, Kramár EA, López AJ, Huynh G, Wood MA, Kwapis JL.
Learn Mem 25(3):109-114. doi: 10.1101/lm.046920.117. Print 2018 Mar. 2018
6HDAC3, PDCD5
Programmed cell death 5 mediates HDAC3 decay to promote genotoxic stress response.
Choi HK, Choi Y, Park ES, Park SY, Lee SH, Seo J, Jeong MH, Jeong JW, Jeong JH, Lee PC, Choi KC, Yoon HG.
Nat Commun 6:7390. doi: 10.1038/ncomms8390. Erratum in: Nat Commun. 2015;6:8225. Jeong, Jae-Ho [Corrected to Cheong, Jae-Ho]. 2015
7HDAC3, NCOR2
Activation of p53 transcriptional activity by SMRT: a histone deacetylase 3-independent function of a transcriptional corepressor.
Adikesavan AK, Karmakar S, Pardo P, Wang L, Liu S, Li W, Smith CL.
Mol Cell Biol 34(7):1246-61. doi: 10.1128/MCB.01216-13. Epub 2014 Jan 21. 2014
8HDAC3, TBX5
Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis.
Lewandowski SL, Janardhan HP, Smee KM, Bachman M, Sun Z, Lazar MA, Trivedi CM.
Hum Mol Genet 23(14):3801-9. doi: 10.1093/hmg/ddu093. Epub 2014 Feb 23. 2014
9HDAC3
Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo.
You SH, Lim HW, Sun Z, Broache M, Won KJ, Lazar MA.
Nat Struct Mol Biol 20(2):182-7. doi: 10.1038/nsmb.2476. Epub 2013 Jan 6. 2013
10HDAC3
Histone deacetylase 3 is required for maintenance of bone mass during aging.
McGee-Lawrence ME, Bradley EW, Dudakovic A, Carlson SW, Ryan ZC, Kumar R, Dadsetan M, Yaszemski MJ, Chen Q, An KN, Westendorf JJ.
Bone 52(1):296-307. doi: 10.1016/j.bone.2012.10.015. Epub 2012 Oct 18. Erratum in: Bone. 2013 Mar;53(1):320. 2013
11ESR1, HDAC3
HDAC3 regulates stability of estrogen receptor α mRNA.
Oie S, Matsuzaki K, Yokoyama W, Murayama A, Yanagisawa J.
Biochem Biophys Res Commun 432(2):236-41. doi: 10.1016/j.bbrc.2013.02.007. Epub 2013 Feb 10. 2013
12HDAC3, NCOR2
Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor.
Sun Z, Feng D, Fang B, Mullican SE, You SH, Lim HW, Everett LJ, Nabel CS, Li Y, Selvakumaran V, Won KJ, Lazar MA.
Mol Cell 52(6):769-82. doi: 10.1016/j.molcel.2013.10.022. Epub 2013 Nov 21. 2013
13AXIN2, HDAC3, RUNX2
Runx2 protein represses Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-deficient mice.
McGee-Lawrence ME, Li X, Bledsoe KL, Wu H, Hawse JR, Subramaniam M, Razidlo DF, Stensgard BA, Stein GS, van Wijnen AJ, Lian JB, Hsu W, Westendorf JJ.
J Biol Chem 288(8):5291-302. doi: 10.1074/jbc.M112.414995. Epub 2013 Jan 7. 2013
14ATXN7, HDAC3
Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model.
Duncan CE, An MC, Papanikolaou T, Rugani C, Vitelli C, Ellerby LM.
Mol Neurodegener 8:42. doi: 10.1186/1750-1326-8-42. 2013
15HDAC3
Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages.
Chen X, Barozzi I, Termanini A, Prosperini E, Recchiuti A, Dalli J, Mietton F, Matteoli G, Hiebert S, Natoli G.
Proc Natl Acad Sci U S A 109(42):E2865-74. doi: 10.1073/pnas.1121131109. Epub 2012 Jul 16. 2012
16EMD, HDAC3
The nuclear envelope protein emerin binds directly to histone deacetylase 3 (HDAC3) and activates HDAC3 activity.
Demmerle J, Koch AJ, Holaska JM.
J Biol Chem 287(26):22080-8. doi: 10.1074/jbc.M111.325308. Epub 2012 May 8. 2012
17HDAC3
Histone deacetylase 3 modulates the expansion of human hematopoietic stem cells.
Elizalde C, Fernández-Rueda J, Salcedo JM, Dorronsoro A, Ferrin I, Jakobsson E, Trigueros C.
Stem Cells Dev 21(14):2581-91. doi: 10.1089/scd.2011.0698. Epub 2012 May 8. 2012
18HDAC3
Histone deacetylase complexes promote trinucleotide repeat expansions.
Debacker K, Frizzell A, Gleeson O, Kirkham-McCarthy L, Mertz T, Lahue RS.
PLoS Biol 10(2):e1001257. doi: 10.1371/journal.pbio.1001257. Epub 2012 Feb 21. 2012
19HDAC3
Regulated clearance of histone deacetylase 3 protects independent formation of nuclear receptor corepressor complexes.
Guo C, Gow CH, Li Y, Gardner A, Khan S, Zhang J.
J Biol Chem 287(15):12111-20. doi: 10.1074/jbc.M111.327023. Epub 2012 Feb 15. 2012
20HDAC3
Structure of HDAC3 bound to co-repressor and inositol tetraphosphate.
Watson PJ, Fairall L, Santos GM, Schwabe JW.
Nature 481(7381):335-40. doi: 10.1038/nature10728. 2012
21ETV6, HDAC3, IRF8, PDGFRB, PTPN13
The leukemia-associated fusion protein Tel-platelet-derived growth factor receptor β (Tel-PdgfRβ) inhibits transcriptional repression of PTPN13 gene by interferon consensus sequence binding protein (Icsbp).
Huang W, Hu L, Bei L, Hjort E, Eklund EA.
J Biol Chem 287(11):8110-25. doi: 10.1074/jbc.M111.294884. Epub 2012 Jan 18. 2012
22HDAC3, IL10, IL12B
IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis.
Kobayashi T, Matsuoka K, Sheikh SZ, Russo SM, Mishima Y, Collins C, deZoeten EF, Karp CL, Ting JP, Sartor RB, Plevy SE.
J Immunol 189(4):1792-9. doi: 10.4049/jimmunol.1200042. Epub 2012 Jul 11. 2012
23HDAC3, NCOR2
Regulated clearance of histone deacetylase 3 protects independent formation of nuclear receptor corepressor complexes.
Guo C, Gow CH, Li Y, Gardner A, Khan S, Zhang J.
J Biol Chem 287(15):12111-20. doi: 10.1074/jbc.M111.327023. Epub 2012 Feb 15. 2012
24CCL2, HDAC2, HDAC3, MS4A2
Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.
Kim Y, Kim K, Park D, Lee E, Lee H, Lee YS, Choe J, Jeoung D.
J Biol Chem 287(31):25844-59. doi: 10.1074/jbc.M112.348284. Epub 2012 Jun 7. 2012
25ATF3, HDAC3, HDAC6, JDP2
The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter.
Darlyuk-Saadon I, Weidenfeld-Baranboim K, Yokoyama KK, Hai T, Aronheim A.
Biochim Biophys Acta 1819(11-12):1142-53. doi: 10.1016/j.bbagrm.2012.09.005. Epub 2012 Sep 16. 2012
26HDAC3
HDAC3 is a critical negative regulator of long-term memory formation.
McQuown SC, Barrett RM, Matheos DP, Post RJ, Rogge GA, Alenghat T, Mullican SE, Jones S, Rusche JR, Lazar MA, Wood MA.
J Neurosci 31(2):764-74. 2011
27GPS2, HDAC3, NCOR, NCOR2, TBL1X
Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery.
Oberoi J, Fairall L, Watson PJ, Yang JC, Czimmerer Z, Kampmann T, Goult BT, Greenwood JA, Gooch JT, Kallenberger BC, Nagy L, Neuhaus D, Schwabe JW.
Nat Struct Mol Biol 18(2):177-84. Epub 2011 Jan 16. 2011
28HDAC3, NR1D1
A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism.
Feng D, Liu T, Sun Z, Bugge A, Mullican SE, Alenghat T, Liu XS, Lazar MA.
Science 331(6022):1315-9. 2011
29HDAC3, HDAC7, MITF
HDAC3 and HDAC7 have opposite effects on osteoclast differentiation.
Pham L, Kaiser B, Romsa A, Schwarz T, Gopalakrishnan R, Jensen ED, Mansky KC.
J Biol Chem 286(14):12056-65. Epub 2011 Feb 15. 2011
30HDAC3
HDAC3 at the fulcrum of an epithelial-mesenchymal balance.
Mani SA, Barton MC.
Mol Cell 43(5):697-8. 2011
31HDAC3, WDR5
Interplay between HDAC3 and WDR5 is essential for hypoxia-induced epithelial-mesenchymal transition.
Wu MZ, Tsai YP, Yang MH, Huang CH, Chang SY, Chang CC, Teng SC, Wu KJ.
Mol Cell 43(5):811-22. 2011
32HDAC3
Histone deacetylase 3 regulates smooth muscle differentiation in neural crest cells and development of the cardiac outflow tract.
Singh N, Trivedi CM, Lu M, Mullican SE, Lazar MA, Epstein JA.
Circ Res 109(11):1240-9. doi: 10.1161/CIRCRESAHA.111.255067. Epub 2011 Sep 29. 2011
33HDAC3, L3MBTL2
Histone deacetylase 3 is selectively involved in L3MBTL2-mediated transcriptional repression.
Yoo JY, Choi KC, Kang H, Kim YJ, Lee J, Jun WJ, Kim MJ, Lee YH, Lee OH, Yoon HG.
FEBS Lett 584(11):2225-30. Epub 2010 Apr 10.PMID: 20385135 2010
34CREB3, HDAC3
HDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells.
Kim HC, Choi KC, Choi HK, Kang HB, Kim MJ, Lee YH, Lee OH, Lee J, Kim YJ, Jun W, Jeong JW, Yoon HG.
Cell Mol Life Sci 67(20):3499-510. Epub 2010 May 15.PMID: 20473547 2010
35HDAC3, SIAH2, SKI
The Ski protein negatively regulates Siah2-mediated HDAC3 degradation.
Zhao HL, Ueki N, Hayman MJ.
Biochem Biophys Res Commun 399(4):623-8. Epub 2010 Aug 4. 2010
36CCAR2, HDAC3
HDAC3 is negatively regulated by the nuclear protein DBC1.
Chini CC, Escande C, Nin V, Chini EN.
J Biol Chem 285(52):40830-7. Epub 2010 Oct 28. 2010
37HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men.
Yang XJ, Seto E.
Nat Rev Mol Cell Biol 9(3):206-18. Review. 2008
38HDAC1, HDAC3, NIPBL
The Cohesin loading factor NIPBL recruits histone deacetylases to mediate local chromatin modifications.
Jahnke P, Xu W, Wülling M, Albrecht M, Gabriel H, Gillessen-Kaesbach G, Kaiser FJ.
Nucleic Acids Res 36(20):6450-8. Epub 2008 Oct 14. 2008
39HDAC3, NCOR1
Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology.
Alenghat T, Meyers K, Mullican SE, Leitner K, Adeniji-Adele A, Avila J, Bućan M, Ahima RS, Kaestner KH, Lazar MA.
Nature 456(7224):997-1000. Epub 2008 Nov 26. 2008
40HDAC3
HDAC3 overexpression and colon cancer cell proliferation and differentiation.
Spurling CC, Godman CA, Noonan EJ, Rasmussen TP, Rosenberg DW, Giardina C.
Mol Carcinog 47(2):137-47.PMID: 17849419 2008
41HDAC3
Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control.
Bhaskara S, Chyla BJ, Amann JM, Knutson SK, Cortez D, Sun ZW, Hiebert SW.
Mol Cell 30(1):61-72.PMID: 18406327 2008
42HDAC3, LSS
Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression.
Villagra A, Ulloa N, Zhang X, Yuan Z, Sotomayor E, Seto E.
J Biol Chem 282(49):35457-70. Epub 2007 Oct 9. 2007
43MBD1, HDAC3
The methyl-CpG binding protein MBD1 is required for PML-RARalpha function.
Villa R, Morey L, Raker VA, Buschbeck M, Gutierrez A, De Santis F, Corsaro M, Varas F, Bossi D, Minucci S, Pelicci PG, Di Croce L.
Proc Natl Acad Sci U S A 103(5):1400-5. Epub 2006 Jan 23. 2006
44HDAC3
Comparative application of antibody and gene array for expression profiling in human squamous cell lung carcinoma.
Bartling B, Hofmann HS, Boettger T, Hansen G, Burdach S, Silber RE, Simm A.
Lung Cancer 49(2):145-54. 2005
45THAP7, NCOR1, HDAC3
Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor.
Macfarlan T, Kutney S, Altman B, Montross R, Yu J, Chakravarti D.
J Biol Chem 280(8):7346-58. Epub 2004 Nov 23. 2005
46HDAC3, KLF6, DLK1
Kruppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1.
Li D, Yea S, Li S, Chen Z, Narla G, Banck M, Laborda J, Tan S, Friedman JM, Friedman SL, Walsh MJ.
J Biol Chem 280(29):26941-52. Epub 2005 May 25. 2005
47HDAC3, HDAC4, HDAC5, NCOR1, NCOR2
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.
Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E.
Mol Cell 9(1):45-57. 2002
48HDAC3
The histone deacetylase-3 complex contains nuclear receptor corepressors.
Wen YD, Perissi V, Staszewski LM, Yang WM, Krones A, Glass CK, Rosenfeld MG, Seto E.
Proc Natl Acad Sci U S A 97(13):7202-7. 2000
49HDAC3, NCOR, NCOR2, TBL1X
Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3.
Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J.
EMBO J 19(16):4342-50. 2000
50HDAC3
Genomic Organization and Chromosomal Localization of the Human Histone Deacetylase 3 Gene.
Mahlknecht U, et al.
Genomics 56(2):197-202. 1999
51HDAC3
High resolution physical mapping of human HDAC3, a potential tumor suppressor gene in the 5q31 region.
Mahlknecht U, et al.
Cytogenet Cell Genet 86(3-4):237-239 1999
52HDAC1, HDAC2, HDAC3, KAT2A, KAT2B
Identification and mapping of human histone acetylation modifier gene homologues.
Randhawa GS, et al.
Genomics 51 : 262-269. 1998
53HDAC3
Characterization of a human RPD3 ortholog, HDAC3.
Emiliani S, et al.
Proc Natl Acad Sci U S A 95(6):2795-800. 1998
54HDAC3
Isolation and characterization of cDNAs corresponding to an additonal member of the human histone deacetylase gene family.
Yang WM, et al.
J Biol Chem 272 : 28001-28007. 1997
55HDAC2, HDAC3, YY1
Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3.
Yang WM, et al.
Proc Natl Acad Sci U S A 93 : 12845-12850. 1996