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FLASH GENE
Symbol EIF4A1 contributors: mct/npt - updated : 16-10-2020
HGNC name eukaryotic translation initiation factor 4A, isoform 1
HGNC id 3282
DNA
TYPE functioning gene
STRUCTURE 6.18 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
regionally located tightly linked to CD8 in same orientation
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1758 46 406 - 2020 32392243
11 - 1696 - 347 - 2020 32392243
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a DEAD/H box (Asp-Glu-Ala-Asp/His
  • a C terminal RNA helicase domain
    • HOMOLOGY
    interspecies ortholog to murine Eif401
    homolog to hepatitis C virus non structural protein 3 helicase
    Homologene
    FAMILY
  • eukaryotic translation initiation factor
  • DEAD box protein family
    • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    text
  • EIF4A1 and EIF4A2 are cytoplasmic, whereas EIF4A3 is nuclear-localized
    • basic FUNCTION
  • ATP-dependent RNA helicase
  • involved in the binding of capped mRNA to 40S subunit of ribosome and in mtDNA metabolism
  • plays a key role in unwinding of mRNA and scanning during translation initiation (Marintchev 2008)
  • is a DEAD-box helicase that stimulates translation initiation by unwinding mRNA secondary structure
  • EIF4A1 and EIF4A2 are required for translation initiation, but EIF4A3 participates in the exon junction complex (EJC) and functions in RNA metabolism including nonsense-mediated RNA decay (NMD)
  • EIF4G1, EIF4E, EIF4A1, and EIF4B, facilitate the recruitment of mRNA onto the preassembled 43S pre-initiation complex (PIC), thus leading to the formation of the 48S PIC
  • key component of the translation initiation machinery and is required for the translation of many pro-oncogenic mRNAs
    • CELLULAR PROCESS nucleotide, transcription
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • assembling with eIF4E and eIF4E kinase (MNK1), eIF4B, eIF4G, PABPC1 to form eIF4F eukaryotic translation initiation complex
  • part of eIF4A/4G/4H helicase complex (Marintchev 2008)
    • INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • ATP
    • protein
  • interacting with PAIP1
  • interacting with UPF2
  • interacting with two accessory factors, eIF4B and eIF4H(forms a stable complex with RNA in the with RNA in the presence of AMPPNP and that eIF4B or eIF4H can add to this complex, also dependent on AMPPNP) (Rozovsky 2008)
  • PAIP1 act as a translational activator in 5 prime cap-dependent translation by interacting with PABPC1 and the initiation factors EIF4A1 and EIF3A
  • EIF4A1 and poly(A)-binding activities of ELAVL4 are not only important for stimulating translation but also are essential for ELAVL4-induced neurite outgrowth
  • direct association of PKP1 with the eukaryotic translation initiation factor 4A1 (EIF4A1), and PKP1 directly promoted EIF4A1 adenosine triphosphatase activity
  • EIF4H is much less efficient at stimulating EIF4A1 unwinding activity than EIF4B, implying that EIF4H is not able to completely substitute for EIF4B in duplex unwinding
  • EIF4G2 associates with EIF2B4 and EIF4A1 to stimulate Internal Ribosome Entry Sites (IRES)-dependent translation of cellular mRNAs
  • EIF4H (eukaryotic translation initiation factor 4H), is an activator of the RNA helicase EIF4A1
  • EIF4G2 and EIF4G1 share many binding proteins, such as the eukaryotic translation initiation factors EIF3 and EIF4A1 and ribosomal proteins
  • USP9X is a novel regulator of the translation initiation process via deubiquitination of EIF4A1, which offers new insight in understanding the pivotal role of USP9X in malignancies and neurodevelopmental disorders
  • RNA helicase EIF4A1 is needed to ensure translation of the long and the known short isoforms of MAPKAPK2, of which the molecular properties were determined
  • USP15 could interact with EIF4A1, thereby promoting translational efficacy in keratinocytes, which is essential for keratinocyte proliferation and migration
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in lung carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could serve as potential biomarkers of clear cell renal cell carcinoma (ccRCC)
    • Therapy target
    ANIMAL & CELL MODELS