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FLASH GENE
Symbol EIF4A1 contributors: mct/npt - updated : 16-10-2020
HGNC name eukaryotic translation initiation factor 4A, isoform 1
HGNC id 3282
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a DEAD/H box (Asp-Glu-Ala-Asp/His
  • a C terminal RNA helicase domain
  • HOMOLOGY
    interspecies ortholog to murine Eif401
    homolog to hepatitis C virus non structural protein 3 helicase
    Homologene
    FAMILY
  • eukaryotic translation initiation factor
  • DEAD box protein family
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    text
  • EIF4A1 and EIF4A2 are cytoplasmic, whereas EIF4A3 is nuclear-localized
  • basic FUNCTION
  • ATP-dependent RNA helicase
  • involved in the binding of capped mRNA to 40S subunit of ribosome and in mtDNA metabolism
  • plays a key role in unwinding of mRNA and scanning during translation initiation (Marintchev 2008)
  • is a DEAD-box helicase that stimulates translation initiation by unwinding mRNA secondary structure
  • EIF4A1 and EIF4A2 are required for translation initiation, but EIF4A3 participates in the exon junction complex (EJC) and functions in RNA metabolism including nonsense-mediated RNA decay (NMD)
  • EIF4G1, EIF4E, EIF4A1, and EIF4B, facilitate the recruitment of mRNA onto the preassembled 43S pre-initiation complex (PIC), thus leading to the formation of the 48S PIC
  • key component of the translation initiation machinery and is required for the translation of many pro-oncogenic mRNAs
  • CELLULAR PROCESS nucleotide, transcription
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • assembling with eIF4E and eIF4E kinase (MNK1), eIF4B, eIF4G, PABPC1 to form eIF4F eukaryotic translation initiation complex
  • part of eIF4A/4G/4H helicase complex (Marintchev 2008)
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • ATP
  • protein
  • interacting with PAIP1
  • interacting with UPF2
  • interacting with two accessory factors, eIF4B and eIF4H(forms a stable complex with RNA in the with RNA in the presence of AMPPNP and that eIF4B or eIF4H can add to this complex, also dependent on AMPPNP) (Rozovsky 2008)
  • PAIP1 act as a translational activator in 5 prime cap-dependent translation by interacting with PABPC1 and the initiation factors EIF4A1 and EIF3A
  • EIF4A1 and poly(A)-binding activities of ELAVL4 are not only important for stimulating translation but also are essential for ELAVL4-induced neurite outgrowth
  • direct association of PKP1 with the eukaryotic translation initiation factor 4A1 (EIF4A1), and PKP1 directly promoted EIF4A1 adenosine triphosphatase activity
  • EIF4H is much less efficient at stimulating EIF4A1 unwinding activity than EIF4B, implying that EIF4H is not able to completely substitute for EIF4B in duplex unwinding
  • EIF4G2 associates with EIF2B4 and EIF4A1 to stimulate Internal Ribosome Entry Sites (IRES)-dependent translation of cellular mRNAs
  • EIF4H (eukaryotic translation initiation factor 4H), is an activator of the RNA helicase EIF4A1
  • EIF4G2 and EIF4G1 share many binding proteins, such as the eukaryotic translation initiation factors EIF3 and EIF4A1 and ribosomal proteins
  • USP9X is a novel regulator of the translation initiation process via deubiquitination of EIF4A1, which offers new insight in understanding the pivotal role of USP9X in malignancies and neurodevelopmental disorders
  • RNA helicase EIF4A1 is needed to ensure translation of the long and the known short isoforms of MAPKAPK2, of which the molecular properties were determined
  • USP15 could interact with EIF4A1, thereby promoting translational efficacy in keratinocytes, which is essential for keratinocyte proliferation and migration
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in lung carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could serve as potential biomarkers of clear cell renal cell carcinoma (ccRCC)
  • Therapy target
    ANIMAL & CELL MODELS