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FLASH GENE
Symbol CD68 contributors: mlc - updated : 15-12-2007
HGNC name CD68 antigen
HGNC id 1693
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
Reproductivefemale systemuteruscervix highly
 female systemplacenta  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
Lymphoid/ImmuneB cell
Lymphoid/Immunemacrophage
Lymphoid/ImmuneT cell
cell lineage cells of the mononuclear phagocytic lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal mucin-like domain
  • 9 potential N-glycosylation sites
  • LAMP domain
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murineCd68
    Homologene
    FAMILY member of the LAMP macrosialin family of hemapoietic mucin-like molecules
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    text
  • type 1 membrane protein
  • expressed within the endosomal compartment of the cell and rapidly shuttles to the plasma membrane where it is postulated to participate in cell adhesion and antigen presentation
    • basic FUNCTION
  • macrophage-specific gene, participating in cell adhesion and antigen presentation
  • may also bind oxidized low-density lipoproteins and may contribute to the development of macrophage foam cells in atherosclerotic plaques
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated at multiple levels, which are inextricably interconnected
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS