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FLASH GENE
Symbol HYAL2 contributors: - updated : 07-04-2007
HGNC name hyaluronoglucosaminidase 2
HGNC id 5321
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
Nervousbrain    
 nervecranial nerve  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide in the N-terminus
  • an EGF-like domain
    • isoforms Precursor a preprotein with 473 aminoacids
    HOMOLOGY
    interspecies homolog to murine Hyal2
    intraspecies homolog to testicular SPAM1
    Homologene
    FAMILY glycosyl hydrolase 56 family
    CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lysosome
    text
  • Vacuole
  • Glycosylphosphatidylinositol (GPI)-anchored cell surface protein
    • basic FUNCTION
  • involved in glycosaminoglycan catabolism
  • lysosomal hyaluronidase which specifically hydrolyzes high molecular weight hyaluronan
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with MST1R (negatively regulates MST1R and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in lung tumor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS