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FLASH GENE

Symbol

MZF1

contributors: mct/npt - updated : 17-12-2015

HGNC name	myeloid zinc finger 1
HGNC id	13108

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_198055 6 - 2938 NP_932172 82 734 - 2008 17851584 also called MZF1B exon 1-6 including the N terminal SCAN box NM_003422 6 - 2620 NP_003413 82 734 - 2008 17851584 also called MZF1C/RAZ1 exon 1-6, deletion in 5'UTR NM_001267033 6 initiation site 2694 NP_001253962 - 290 myeloid cells 2008 17851584 also called MZF1 (A) initiating through intron 5 variant 4 - initiation site - isoform 4 87 775 myeloid cells 2008 17851584 also called MZF2 N terminus different from MZF1

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine parathyroid       highly Lymphoid/Immune lymph node       highly Nervous nerve cranial nerve     highly Reproductive male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic myelocyte

cell lineage	hemaopoietic (myeloid) cell lineage
cell lines
fluid/secretion

at STAGE

physiological period

fetal

Text

liver

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal SCAN box (leucine rich), mediating interactions between members of a subfamily of zinc-finger transcription factors, and necessary for association with promyelocytic leukemia nuclear bodies (Noll 2008)
	13 zinc finger (C2H2) motifs
	a glycine-proline-rich region between the fourth and fifth zinc finger motif

secondary structure

each monomer consists of five alpha helices in two subdomains connected by the alpha2-alpha3 loop

conjugated

MetalloP

mono polymer

dimer

HOMOLOGY

Homologene

FAMILY	zinc finger protein family, C2H2 type, Kruppel-like
	SCAN domain family transcription factors, KRAB subfamily

CATEGORY

transcription factor , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	negative regulator of myelopoiesis development of neutrophilic granulocytes
	transcription factor that plays an important role in blood cell development (Noll 2008)
	with Sp1/Sp3 binding to the promoter region, drive the PADI1 expression (Dong 2008)
	its activation in striatal astrocytes can enhance the biosynthesis and release of FGF2 through apomorphine (Luo 2009)
	induces invasion and metastasis in colorectal and cervical cancer, at least in part by regulating AXL gene (Mudduluru 2010)
	suppresses prostate tumor growth through enforcing ferroportin-conducted iron egress
	is likely an endogenous trigger of neuropathic pain and might serve as a potential target for preventing and treating this disorder
	MZF1 regulates the CTGF and NOV genes in the hematopoietic compartment, and may be involved in their respective functions in the stroma
	role of MZF1 in myeloid differentiation and leukemia, and is involved in the etiology of major solid tumors

CELLULAR PROCESS	cell life, proliferation/growth
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	form dimer via its highly conserved SCAN motif (Noll 2008)
	constituent of promyelocytic leukemia nuclear bodies (PML-NBs)(Noll 2008)

INTERACTION

DNA

RNA

small molecule

protein	inhibiting granulocyte CSF(1) in vitro
	SCAND1
	interact with LDOC1 and enhance the activity of LDOC1 for inducing apoptosis
	interacting with FHL3
	ZNF24 is a novel heterodimeric partner of MZF1 that also associates with PML-NBs in a unique ring-type pattern (Noll 2008)
	binds to the AXL promoter, transactivates promoter activity, and enhances AXL-mRNA and protein expression in a dose-dependent manner (Mudduluru 2010)
	promoter of SERPINA3 is transcriptionally activated by three transcription factors (TFs) (SP1, MZF1 and ZBTB7B)
	MZF1 regulates GAPDH, indicating a role for GAPDH in calcitriol-mediated signaling
	MZF1 is a transcription factor that regulates SLC40A1 expression
	interaction of MZF1 with the CTGF and NOV promoters in several cell types

cell & other

retinoic acid responsive

REGULATION

induced by

retinoic acid

Other

modified by SUMOylation, which provides further support for localization of MZF1 protein complexes to PML-NBs (Noll 2008)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   induces migration and invasion in colorectal and cervical cancer cells (Mudduluru 2010)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	antisense oligonucleotide MZF1 is a new reagent for cancer therapy (Hsieh 2007)

ANIMAL & CELL MODELS