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FLASH GENE

Symbol

AKT2

contributors: mct/npt/pgu - updated : 24-08-2017

HGNC name	v-akt murine thymoma viral oncogene homolog 2
HGNC id	392

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

NIDDM6

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in ovarian carcinoma tumoral   amplification     in ovarian and pancreatic carcinomas tumoral somatic mutation       in the kinase domain occuring in a small fraction of common cancers tumoral       gain of function associated with the survival of melanoma cells tumoral   amplification     amplification of AKT1 and/or AKT2 and high-level polysomy were found in lung carcinomas tumoral fusion       recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer brain glioma/neuroblstoma targeting AKT2 and AKT3 may hold promise for the treatment of patients with gliomas cardiovascular atheroma cardiac argeting AKT2 in macrophages might be beneficial for treating atherosclerosis.

ANIMAL & CELL MODELS

Akt2-deficient mice showed abnormal elastic fibers and reduced medial thickness in the aortic wall