| 1 | AKT1, AKT2, VRK2
|
| Functional characterization of lysosomal interaction of Akt with VRK2.
|
| Hirata N, Suizu F, Matsuda-Lennikov M, Tanaka T, Edamura T, Ishigaki S, Donia T, Lithanatudom P, Obuse C, Iwanaga T, Noguchi M.
|
| Oncogene Oct;37(40):5367-5386. doi: 10.1038/s41388-018-0330-0. Epub 2018 Jun 5. 2018
|
| 2 | AKT2, BCAM
|
| Recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma.
|
| Kannan K, Coarfa C, Chao PW, Luo L, Wang Y, Brinegar AE, Hawkins SM, Milosavljevic A, Matzuk MM, Yen L.
|
| Proc Natl Acad Sci U S A 112(11):E1272-7. doi: 10.1073/pnas.1501735112. Epub 2015 Mar 2.
2015
|
| 3 | AKT2
|
| Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis.
|
| Rotllan N, Chamorro-Jorganes A, Araldi E, Wanschel AC, Aryal B, Aranda JF, Goedeke L, Salerno AG, Ramírez CM, Sessa WC, Suárez Y, Fernández-Hernando C.
|
| FASEB J 29(2):597-610. doi: 10.1096/fj.14-262097. Epub 2014 Nov 12.
2015
|
| 4 | AKT1, AKT2
|
| Akt recruits Dab2 to albumin endocytosis in the proximal tubule.
|
| Koral K, Li H, Ganesh N, Birnbaum MJ, Hallows KR, Erkan E.
|
| Am J Physiol Renal Physiol 307(12):F1380-9. doi: 10.1152/ajprenal.00454.2014. Epub 2014 Sep 24.
2014
|
| 5 | AKT1, AKT2, AKT3
|
| Differential effects of Akt isoforms on somatic cell reprogramming.
|
| Tang Y, Jiang Z, Luo Y, Zhao X, Wang L, Norris C, Tian XC.
|
| J Cell Sci 127(Pt 18):3998-4008. doi: 10.1242/jcs.150029. Epub 2014 Jul 18.
2014
|
| 6 | AKT2, PLEKHG4, RAC1
|
| Role of the guanine nucleotide exchange factor in Akt2-mediated plasma membrane translocation of GLUT4 in insulin-stimulated skeletal muscle.
|
| Takenaka N, Yasuda N, Nihata Y, Hosooka T, Noguchi T, Aiba A, Satoh T.
|
| Cell Signal 26(11):2460-9. doi: 10.1016/j.cellsig.2014.07.002. Epub 2014 Jul 12.
2014
|
| 7 | AKT2
|
| PTEN-deficient tumors depend on AKT2 for maintenance and survival.
|
| Chin YR, Yuan X, Balk SP, Toker A.
|
| Cancer Discov 4(8):942-55. doi: 10.1158/2159-8290.CD-13-0873. Epub 2014 May 16.
2014
|
| 8 | AKT1, AKT2, CK2
|
| Differential phosphorylation of Akt1 and Akt2 by protein kinase CK2 may account for isoform specific functions.
|
| Girardi C, James P, Zanin S, Pinna LA, Ruzzene M.
|
| Biochim Biophys Acta 1843(9):1865-74. doi: 10.1016/j.bbamcr.2014.04.020. Epub 2014 Apr 24.
2014
|
| 9 | AKT1, AKT2, CSNK2A1
|
| Differential phosphorylation of Akt1 and Akt2 by protein kinase CK2 may account for isoform specific functions.
|
| Girardi C, James P, Zanin S, Pinna LA, Ruzzene M.
|
| Biochim Biophys Acta 1843(9):1865-74. doi: 10.1016/j.bbamcr.2014.04.020. Epub 2014 Apr 24.
2014
|
| 10 | AKT2
|
| Neutrophil AKT2 regulates heterotypic cell-cell interactions during vascular inflammation.
|
| Li J, Kim K, Hahm E, Molokie R, Hay N, Gordeuk VR, Du X, Cho J.
|
| J Clin Invest 124(4):1483-96. doi: 10.1172/JCI72305. Epub 2014 Mar 18.
2014
|
| 11 | AKT1, AKT2, DAB2
|
| Akt recruits Dab2 to albumin endocytosis in the proximal tubule.
|
| Koral K, Li H, Ganesh N, Birnbaum MJ, Hallows KR, Erkan E.
|
| Am J Physiol Renal Physiol 307(12):F1380-9. doi: 10.1152/ajprenal.00454.2014. Epub 2014 Sep 24.
2014
|
| 12 | AKT2, SLC2A4, TMOD3
|
| Tropomodulin3 as the link between insulin-activated AKT2 and cortical actin remodeling in preparation of GLUT4 exocytosis.
|
| Lim CY, Han W.
|
| Bioarchitecture 4(6):210-4. doi: 10.1080/19490992.2015.1031949. Epub 2015 Aug 17.
2014
|
| 13 | AKT1, AKT2, PDPK1
|
| PI3 kinase directly phosphorylates Akt1/2 at Ser473/474 in the insulin signal transduction pathway.
|
| Tsuchiya A, Kanno T, Nishizaki T.
|
| J Endocrinol 220(1):49-59. doi: 10.1530/JOE-13-0172. Print 2014 Jan.
2013
|
| 14 | AKT2, CDKN1A
|
| Characterization of the Akt2 domain essential for binding nuclear p21cip1 to promote cell cycle arrest during myogenic differentiation.
|
| Heron-Milhavet L, Franckhauser C, Fernandez A, Lamb NJ.
|
| PLoS One 8(10):e76987. doi: 10.1371/journal.pone.0076987. eCollection 2013.
2013
|
| 15 | AKT2
|
| AKT2 is essential to maintain podocyte viability and function during chronic kidney disease.
|
| Canaud G, Bienaimé F, Viau A, Treins C, Baron W, Nguyen C, Burtin M, Berissi S, Giannakakis K, Muda AO, Zschiedrich S, Huber TB, Friedlander G, Legendre C, Pontoglio M, Pende M, Terzi F.
|
| Nat Med 19(10):1288-96. doi: 10.1038/nm.3313. Epub 2013 Sep 22.
2013
|
| 16 | AKT2
|
| Akt2 regulates Rac1 activity in the insulin-dependent signaling pathway leading to GLUT4 translocation to the plasma membrane in skeletal muscle cells.
|
| Nozaki S, Takeda T, Kitaura T, Takenaka N, Kataoka T, Satoh T.
|
| Cell Signal 25(6):1361-71. doi: 10.1016/j.cellsig.2013.02.023. Epub 2013 Mar 14.
2013
|
| 17 | AKT2
|
| AKT2 confers protection against aortic aneurysms and dissections.
|
| Shen YH, Zhang L, Ren P, Nguyen MT, Zou S, Wu D, Wang XL, Coselli JS, LeMaire SA.
|
| Circ Res 112(4):618-32. doi: 10.1161/CIRCRESAHA.112.300735. Epub 2012 Dec 18.
2013
|
| 18 | AKT2, ASAH1
|
| Akt2 and acid ceramidase cooperate to induce cell invasion and resistance to apoptosis.
|
| Berndt N, Patel R, Yang H, Balasis ME, Sebti SM.
|
| Cell Cycle 12(13):2024-32. doi: 10.4161/cc.25043. Epub 2013 Jun 6.
2013
|
| 19 | AKT1, AKT2
|
| Molecular alterations in AKT and its protein activation in human lung carcinomas.
|
| Dobashi Y, Kimura M, Matsubara H, Endo S, Inazawa J, Ooi A.
|
| Hum Pathol 43(12):2229-40. doi: 10.1016/j.humpath.2012.03.015. Epub 2012 Jun 28.
2012
|
| 20 | AKT1, AKT2
|
| Differential function of Akt1 and Akt2 in human adipocytes.
|
| Fischer-Posovszky P, Tews D, Horenburg S, Debatin KM, Wabitsch M.
|
| Mol Cell Endocrinol 358(1):135-43. doi: 10.1016/j.mce.2012.03.018. Epub 2012 Mar 29.
2012
|
| 21 | AKT2, NFATC1
|
| Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores.
|
| Martin VA, Wang WH, Lipchik AM, Parker LL, He Y, Zhang S, Zhang ZY, Geahlen RL.
|
| Cell Signal 24(5):1064-73. doi: 10.1016/j.cellsig.2012.01.001. Epub 2012 Jan 11.
2012
|
| 22 | AKT2, CDH1, SNAI1
|
| Akt2 interacts with Snail1 in the E-cadherin promoter.
|
| Villagrasa P, Díaz VM, Viñas-Castells R, Peiró S, Del Valle-Pérez B, Dave N, Rodríguez-Asiain A, Casal JI, Lizcano JM, Duñach M, García de Herreros A.
|
| Oncogene 31(36):4022-33. doi: 10.1038/onc.2011.562.
2012
|
| 23 | AKT2
|
| An activating mutation of AKT2 and human hypoglycemia.
|
| Hussain K, Challis B, Rocha N, Payne F, Minic M, Thompson A, Daly A, Scott C, Harris J, Smillie BJ, Savage DB, Ramaswami U, De Lonlay P, O'Rahilly S, Barroso I, Semple RK.
|
| Science 334(6055):474. doi: 10.1126/science.1210878. Epub 2011 Oct 6.
2011
|
| 24 | AKT2, WDFY2
|
| Isoform-specific regulation of Akt signaling by the endosomal protein WDFY2.
|
| Walz HA, Shi X, Chouinard M, Bue CA, Navaroli DM, Hayakawa A, Zhou QL, Nadler J, Leonard DM, Corvera S.
|
| J Biol Chem 285(19):14101-8. Epub 2010 Feb 26. 2010
|
| 25 | AKT2, GRM1
|
| AKT2 is a downstream target of metabotropic glutamate receptor 1 (Grm1).
|
| Shin SS, Wall BA, Goydos JS, Chen S.
|
| Pigment Cell Melanoma Res 23(1):103-11. Epub 2009 Oct 20.PMID: 19843246 2010
|
| 26 | AKT2, PALLD
|
| Akt2 regulates expression of the actin-bundling protein palladin.
|
| Chin YR, Toker A.
|
| FEBS Lett 584(23):4769-74. Epub 2010 Nov 2. 2010
|
| 27 | AKT2, AKT3
|
| Akt2 and Akt3 play a pivotal role in malignant gliomas.
|
| Mure H, Matsuzaki K, Kitazato KT, Mizobuchi Y, Kuwayama K, Kageji T, Nagahiro S.
|
| Neuro Oncol 12(3):221-32. Epub 2009 Dec 21.
2010
|
| 28 | AKT1, AKT2, AKT3
|
| The Akt isoforms are present at distinct subcellular locations.
|
| Santi SA, Lee H.
|
| Am J Physiol Cell Physiol 298(3):C580-91. Epub 2009 Dec 16.
2010
|
| 29 | AKT2, CRTC2, MAPKAP1
|
| Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells.
|
| Lazorchak AS, Liu D, Facchinetti V, Di Lorenzo A, Sessa WC, Schatz DG, Su B.
|
| Mol Cell 39(3):433-43. doi: 10.1016/j.molcel.2010.07.031.
2010
|
| 30 | AKT1,AKT2,CREB1
|
| Differential activation of CREB by Akt1 and Akt2.
|
| Kato S, Ding J, Du K.
|
| Biochem Biophys Res Commun 354(4):1061-6. Epub 2007 Jan 25. 2007
|
| 31 | AKT2, MTOR, RIPK1, SPHK1, TRAF2
|
| Sphingosine kinase 1 expression is regulated by signaling through PI3K, AKT2, and mTOR in human coronary artery smooth muscle cells.
|
| Francy JM, Nag A, Conroy EJ, Hengst JA, Yun JK.
|
| Biochim Biophys Acta 1769(4):253-65. Epub 2007 Apr 3. 2007
|
| 32 | AKT1, AKT2, AKT3
|
| Mutational analysis of AKT1, AKT2 and AKT3 genes in common human carcinomas.
|
| Soung YH, Lee JW, Nam SW, Lee JY, Yoo NJ, Lee SH.
|
| Oncology 70(4):285-9. Epub 2006 Oct 16.
2006
|
| 33 | AKT2
|
| The effects of antisense AKT2 RNA on the inhibition of malignant glioma cell growth in vitro and in vivo.
|
| Pu P, Kang C, Li J, Jiang H, Cheng J.
|
| J Neurooncol 76(1):1-11. 2006
|
| 34 | AKT2, AKT1
|
| Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition.
|
| Irie HY, Pearline RV, Grueneberg D, Hsia M, Ravichandran P, Kothari N, Natesan S, Brugge JS.
|
| J Cell Biol 171(6):1023-34. 2005
|
| 35 | AKT2, NIDDM6
|
| Activation of a GST-tagged AKT2/PKBbeta.
|
| Baer K, Lisinski I, Gompert M, Stuhlmann D, Schmolz K, Klein HW, Al-Hasani H.
|
| Biochim Biophys Acta 1725(3):340-7. Epub 2005 Apr 20. 2005
|
| 36 | AKT2, NIDDM6
|
| A family with severe insulin resistance and diabetes due to a mutation in AKT2.
|
| George S, Rochford JJ, Wolfrum C, Gray SL, Schinner S, Wilson JC, Soos MA, Murgatroyd PR, Williams RM, Acerini CL, Dunger DB, Barford D, Umpleby AM, Wareham NJ, Davies HA, Schafer AJ, Stoffel M, O'Rahilly S, Barroso I.
|
| Science 304(5675):1325-8. 2004
|
| 37 | AKT2, COX6B1, DAPK3, ETV2, KHSRP, OR7A10, OR7A5, OR7D2, OR7E24, S1PR5, ZNF607, ZNF610, ZSCAN5C
|
| The DNA sequence and biology of human chromosome 19.
|
| Grimwood J, and al.
|
| Nature 428(6982):529-35. 2004
|
| 38 | AKT1, AKT2, AKT3
|
| AKT plays a central role in tumorigenesis.
|
| Testa JR, Bellacosa A.
|
| Proc Natl Acad Sci U S A 98(20):10983-5. No abstract available. 2001
|
| 39 | AKT1, AKT2, AKT3, TCL1A, TCL1B
|
| The protooncogene TCL1 is an Akt kinase coactivator.
|
| Laine J, Kunstle G, Obata T, Sha M, Noguchi M.
|
| Mol Cell 6(2):395-407. 2000
|
| 40 | AKT1, AKT2, FOXO3, FOXO4
|
| Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.
|
| Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME.
|
| Cell 96(6):857-68. 1999
|
| 41 | AKT2, ZNF146
|
| Amplification of DNA sequences from chromosome 19q13.1 in human pancreatic cell lines.
|
| Curtis LJ, Li Y, Gerbault-Seureau M, Kuick R, Dutrillaux AM, Goubin G, Fawcett J, Cram S, Dutrillaux B, Hanash S, Muleris M.
|
| Genomics 53 : 42-55. 1998
|
| 42 | AKT1, AKT2, IGF1, IGF1R
|
| Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I.
|
| Kulik G, et al.
|
| Mol Cell Biol 18(11):6711-8. 1998
|
| 43 | AKT1, AKT2
|
| Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
|
| Datta SR, et al.
|
| Cell 91(2):231-41. 1997
|
| 44 | AKT1, AKT2, PIK3CA
|
| The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.
|
| Kennedy SG, et al.
|
| Genes Dev 11(6):701-13. 1997
|
| 45 | AKT1, AKT2, IL3, BAD
|
| Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt.
|
| del Peso L, et al.
|
| Science 278(5338):687-9. 1997
|
| 46 | AKT2
|
| AKT2, a putative oncogene encoding a member of a novel subfamily of serine-threonine protein kinases, is amplified and overexpressed in human ovarian carcinomas.
|
| Testa JR, et al.
|
| Am J Hum Genet 51 : A38. 1992
|