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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CA9

contributors: mct - updated : 27-08-2013

HGNC name	carbonic anhydrase IX
HGNC id	1383

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in some human carcinomas tumoral     --over   in MnSOD-positive oligodendroglial brain tumors tumoral     --over   in hereditary nonpolyposis colorectal cancer tumoral     --over   induces weakening of cell adhesions and augmented cell motility by aberrant Rho-GTPase signal transduction ( tumoral     --over   in glioblastoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	is an independent prognostic factor for poor outcome in patients with glioblastoma
	biomarker of aggressive disease in neuroblastomas
Therapy target
	System Type Disorder Pubmed tumor     inhibition of CA9 activity may offer a novel strategy for the clinical treatment of CA9-associated tumors cancer brain glioma/neuroblstoma inhibition of CA9is a potential metabolic target for the treatment of patients with glioblastoma

ANIMAL & CELL MODELS