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FLASH GENE
Symbol CA9 contributors: mct - updated : 27-08-2013
HGNC name carbonic anhydrase IX
HGNC id 1383
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in some human carcinomas
tumoral     --over  
in MnSOD-positive oligodendroglial brain tumors
tumoral     --over  
in hereditary nonpolyposis colorectal cancer
tumoral     --over  
induces weakening of cell adhesions and augmented cell motility by aberrant Rho-GTPase signal transduction (
tumoral     --over  
in glioblastoma
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • is an independent prognostic factor for poor outcome in patients with glioblastoma
  • biomarker of aggressive disease in neuroblastomas
  • Therapy target
    SystemTypeDisorderPubmed
    tumor  
    inhibition of CA9 activity may offer a novel strategy for the clinical treatment of CA9-associated tumors
    cancerbrainglioma/neuroblstoma
    inhibition of CA9is a potential metabolic target for the treatment of patients with glioblastoma
    ANIMAL & CELL MODELS