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FLASH GENE
Symbol CA9 contributors: mct - updated : 27-08-2013
HGNC name carbonic anhydrase IX
HGNC id 1383
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an helix-loop-helix (HLH) N terminal domain, and a unique N-linked glycosylation site (Asn309) that bears high mannose-type glycan structures
  • secretory signal sequence
  • the carbonic anhydrase domain
  • a single transmembrane segment
  • an intra-cytoplasmic tail
    • secondary structure an intramolecular disulfide bridge (Cys119-Cys299)
    conjugated MetalloP
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • eukaryotic-type anhydrase family
    • CATEGORY enzyme , secretory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • membrane-tethered, carbonic anhydrase (CA) enzyme, expressed mainly at the external surface of cells, that catalyzes reversible CO(2) hydration
  • reversibly hydrating Co2 in cellular ion transport and pH homeostasis
  • hypoxia-induced enzyme that has many biologically important functions, including its role in cell adhesion and invasion
  • CA12 with CA9 are major tumor prosurvival pH-regulating enzymes, and their combined targeting shows that they hold potential as anticancer targets
  • strongly involved in high incidences of metastasis and poor prognosis in various human tumors
  • modulates tumor-associated cell migration and invasion
  • is a pivotal mediator of the hypoxia-cAMP-PRKCA axis, which regulates pH in the hypoxic tumor microenvironment
  • actively contributes to cell migration via its ability to facilitate ion transport and pH control at protruding fronts of moving cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • CA9 is a new down-stream target for SRC oncogene
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in some human carcinomas
    tumoral     --over  
    in MnSOD-positive oligodendroglial brain tumors
    tumoral     --over  
    in hereditary nonpolyposis colorectal cancer
    tumoral     --over  
    induces weakening of cell adhesions and augmented cell motility by aberrant Rho-GTPase signal transduction (
    tumoral     --over  
    in glioblastoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is an independent prognostic factor for poor outcome in patients with glioblastoma
  • biomarker of aggressive disease in neuroblastomas
    • Therapy target
    SystemTypeDisorderPubmed
    tumor  
    inhibition of CA9 activity may offer a novel strategy for the clinical treatment of CA9-associated tumors
    cancerbrainglioma/neuroblstoma
    inhibition of CA9is a potential metabolic target for the treatment of patients with glioblastoma
    ANIMAL & CELL MODELS