| Symbol
| OLR1
| contributors: mct - updated : 14-04-2015
|
| HGNC name
| oxidized low density lipoprotein (lectin-like) receptor 1
|
| HGNC id
| 8133
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| constitutional
|
|
| --over
|
| |
in aortic endothelial cells in diabetes | | constitutional
|
|
| --over
|
|
in the tubulointerstitial area may be closely linked to the development and progression of diabetic nephropathy, and in particular the tubulointerstitial damage  | | constitutional
|
|
| --over
|
| |
in endothelial cells of atherosclerotic lesions, but also in macrophages and smooth muscle cells | |
| Susceptibility
|
to acute myocardial infarction (AMI) to coronary artery disease to Alzheimer disease |
| Variant & Polymorphism
SNP
, other
| allele APOE4 associated with 3' UTR/TT increase the risk of AD |
|
SNP in the 3' UTR (C-T, 188bp from the stop codon), and 501G>C polymorphism significantly associated |
|
with AMI |
|
polymorphisms (intron 4/G-->A, intron 5/T-->G, and 3' UTR/T-->C) increasing the risk of coronary artery disease in white women |
| 
|
Candidate gene
Marker
Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| reproduction | pregnancy | | |
| could be a potential target for therapeutic intervention in intrahepatic cholestasis during pregnancy |
| | | |
|
| LOX-1 KO mice have low levels of the immunoglobulins in the heart (vs. the WT mice) and the expression of these immunoglobulins in the LOX-1 KO mice is upregulated several-fold when the mice are infused with Angiotensin II | |
its deletion (Lox-1 knockout, KO) reduces atherosclerosis in LDLr KO mice fed a high cholesterol diet |