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Symbol OLR1 contributors: mct - updated : 14-04-2015
HGNC name oxidized low density lipoprotein (lectin-like) receptor 1
HGNC id 8133
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in aortic endothelial cells in diabetes
constitutional     --over  
in the tubulointerstitial area may be closely linked to the development and progression of diabetic nephropathy, and in particular the tubulointerstitial damage
constitutional     --over  
in endothelial cells of atherosclerotic lesions, but also in macrophages and smooth muscle cells
  • to acute myocardial infarction (AMI)
  • to coronary artery disease
  • to Alzheimer disease
  • Variant & Polymorphism SNP , other
  • allele APOE4 associated with 3' UTR/TT increase the risk of AD
  • SNP in the 3' UTR (C-T, 188bp from the stop codon), and 501G>C polymorphism significantly associated
  • with AMI
  • polymorphisms (intron 4/G-->A, intron 5/T-->G, and 3' UTR/T-->C) increasing the risk of coronary artery disease in white women
  • Candidate gene
    Therapy target
    could be a potential target for therapeutic intervention in intrahepatic cholestasis during pregnancy
  • LOX-1 KO mice have low levels of the immunoglobulins in the heart (vs. the WT mice) and the expression of these immunoglobulins in the LOX-1 KO mice is upregulated several-fold when the mice are infused with Angiotensin II
  • its deletion (Lox-1 knockout, KO) reduces atherosclerosis in LDLr KO mice fed a high cholesterol diet