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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

AXIN1

contributors: mct/pgu - updated : 07-11-2023

HGNC name	axin 1
HGNC id	903

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CMDOH

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation       in hepatocellular (late event for malignant progression), colorectal, ovarian carcinoma, hepatoblastoma and medulloblastoma tumoral     --low   hypermethylated AXIN1 gene significantly correlates with the progression of lung cancer constitutional     --low   during influenza virus infection constitutional       loss of function Inhibition of Axin1 in osteoblast precursor cells leads to defects in postnatal bone growth through suppressing osteoclast formation

Susceptibility

Variant & Polymorphism

Candidate gene	candidate in multiple tumor types; for caudal duplication (murine model)
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive liver AXIN1 may be a potential target for gene therapy of primary hepatocellular carcinoma (HCC) (PMID: 23879168) cancer digestive colon colonic AXIN1 signature offers therapeutic perspectives for Colorectal cancer immunology infectious   potential therapeutic of targeting Axin1 against influenza virus infection cancer reproductive breast AXIN1 is a potential target for the management of ER(+) breast cancer

ANIMAL & CELL MODELS

	AxinFu mice
	Axin1 deficiency in intestinal epithelial cells rendered mice more susceptible to chemically induced colon carcinogenesis, but reduced dextran sulfate sodium-induced colitis by attenuating the induction of a proinflammatory program