| protein
| Gsk-3b |
|
regulating CTNNB1 mediated response through oligomerization of its C terminus |
|
Lrp5 |
|
.gamma-catenin |
|
APC |
|
DVL |
|
PP2A |
|
activates TGF-beta signaling by forming a multimeric complex consisting of SMAD7 and ubiquitin E3 ligase RNF111  |
|
CDH2-axin1-LRP5 interaction negatively regulates Wnt/beta-catenin signaling and is critical in the regulation of osteoblast function, bone formation, and bone mass |
|
interacting with ZBED3 through the "PPPPSPT" motif |
|
associates with the transactivation domain of MYC- dependent on S62 phosphorylation |
|
interacting with DAB2 (could attenuate Wnt/beta-catenin signaling by stabilizing AXIN1 and preventing its translocation to the membrane |
|
SMURF2 is an E3 ubiquitin ligase for AXIN1 |
|
PRMT1 directly interacts with and methylates the 378th arginine residue of AXIN1 (methylation of AXIN1 by PRMT1 may serve as a finely tuned regulation mechanism for Wnt/CTNNB signaling) |
|
functions downstream of the CTNNB1 destruction complex to control the stability of AXIN1 and opposes its TNKS-dependent ubiquitination |
|
bivalent binding of AXIN1 to TNKS is required for AXIN1 turnover, since mutations in either gate-binding glycine residue in AXIN1 lead to its stabilization in the cell |
|
interacts with TNKS2 and the kinesin motor protein KIF3A, forming a ternary complex crucial for SLC2A4 translocation in response to insulin |
|
degradation of cytosolic CTNNB1 by the APC/AXIN1 destruction complex represents the key regulated step of the WNT pathway |
|
involved in protein modification, ubiquitin cycle |
|
HECTD1 promotes the APC-AXIN1 interaction to negatively regulate WNT signaling |
|
MDM2 can inhibit AXIN1-stimulated TP53-dependent apoptosis by suppressing TP53 phosphorylation at Ser 46 and apoptosis-related TP53 transactivational activity |
|
APC2 functions at the embryonic cortex with several protein partners, including AXIN1, to promote mitotic fidelity |
|
AXIN1 and NFE2L2 physically associated in a protein complex that was regulated by WNT3A, involving the central region of AXIN1 and the Neh4/Neh5 domains of NFE2L2 |
|
AXIN1 is a VDR target gene provides novel and fundamental insights into the interactions between the VDR and CTNNB1 signaling pathways |
|
TRIM65 exerted oncogenic activities via ubiquitylation of AXIN1 to activate the CTNNB1 signaling pathway |
|
SAPCD2, a tumor-specific protein, is a novel AXIN1-interacting protein |
|
UCHL5 is required for both the stabilization and the polymerization of AXIN1 proteins |
|
UCHL5 controls CTNNB1 destruction complex function through AXIN1 regulation |
|
is the principal coordinator of the CTNNB1 destruction complex, bringing all its major components in close proximity and thereby vastly accelerating CTNNB1 phosphorylation |
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
| somatic mutation
|
|
|
| |
in hepatocellular (late event for malignant progression), colorectal, ovarian carcinoma, hepatoblastoma and medulloblastoma | | tumoral
|
|
| --low
|
| |
hypermethylated AXIN1 gene significantly correlates with the progression of lung cancer | | constitutional
|
|
| --low
|
| |
during influenza virus infection | | constitutional
|
|
|
| loss of function
| |
Inhibition of Axin1 in osteoblast precursor cells leads to defects in postnatal bone growth through suppressing osteoclast formation | |
