Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DFFB contributors: mct/npt - updated : 21-08-2012
HGNC name DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
HGNC id 2773
Location 1p36.3      Physical location : 3.773.844 - 3.801.992
Synonym name
  • caspase activated deoxyribonuclease
  • caspase-activated nuclease
  • DNA fragmentation factor subunit beta
  • Synonym symbol(s) CAD, CPAN, DFF40, DFF2, DFF-40
    EC.number 3.-.-.-
    DNA
    TYPE functioning gene
    STRUCTURE 28.15 kb     7 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    TNFRSF14 1p36.3-p36.22 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) MGC26818 1p36.32 hypothetical protein MGC26818 MMEL2 1p36 membrane metallo-endopeptidase-like 2 LOC390988 1 similar to RIKEN cDNA B230396O12 LOC390989 1 LOC390989 ARPM2  actin-related protein M2 DKFZp761G0122 1p36.32 hypothetical protein DKFZp761G0122 LOC148872 1p36.32 LOC148872 protein PRDM16 1p36.23-p33 PR domain containing 16 ARHGEF16 1p36.32 Rho guanine exchange factor (GEF) 16 EGFL3 1p36.3 EGF-like-domain, multiple 3 LOC388587 1 LOC388587 LOC127262 1p36.32 hypothetical protein LOC127262 WDR8 1p36.3 WD repeat domain 8 TP73 1p36.33 tumor protein p73 LOC390990 1 LOC390990 FLJ32825 1p36.32 hypothetical protein FLJ32825 LOC388588 1 hypothetical gene supported by BC035379; BC042129 KIAA1185 1p36.32 KIAA1185 protein KIAA0562 1p36.32 KIAA1185 protein DFFB 1p36.3 DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) LOC339448 1p36.32 hypothetical protein LOC339448 LOC390991 1 similar to elongation factor 1 delta SHREW1 1p36.31 transmembrane protein SHREW1 LOC388589 1 LOC388589
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3034 39 338 - 2008 18283539
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth    
    Lymphoid/Immunespleen    
    Reproductivemale systemprostate   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • regulatory CIDE-N domain (cell death inducing DFFA-like effector)
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • triggering DNA fragmentation and chromatin condensation during apoptosis
  • deoxyribose-specific and double-strand-specific enzyme, endonuclease which is primarily responsible for internucleosomal DNA cleavage during the terminal stages of apoptosis
  • exclusively specific for double-stranded DNA
  • caspase 3/DFFB promotes cell differentiation by directly modifying the DNA/nuclear microenvironment, which enhances the expression of critical regulatory genes
  • DFFB-mediated apoptosis plays a significant role in mediating sepsis induced cellular dysfunction
  • involved in apoptotic rearrangement of interchromatin granule clusters (IGCs), with the nuclear matrix and chromatin closely associated, and depend on the activity of protein phosphatases and caspases
  • its caspase-dependent specific activation mediating nuclear fragmentation and oligonucleosomal DNA degradation
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • beta subunit, heterodimerizing with DFFA
  • INTERACTION
    DNA binding (fragment)
    RNA
    small molecule
    protein
  • interacting with DNASE1L3 (providing an alternative mechanism for inducing nuclear changes when the working apoptotic cascade is unsuitable for DFFB activation)
  • cell & other
    REGULATION
    activated by caspase 3 (CASP3)
    inhibited by DFFA (isoforms DFF45,DFF35)
    RNA, heparin and other polyanions
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene unlikely to be a candidate neuroblastoma tumor suppressor gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS