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FLASH GENE
Symbol MRC2 contributors: - updated : 05-07-2005
HGNC name mannose receptor, C type 2
HGNC id 16875
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • large extracellular domain contains an N-terminal cysteine-rich domain
  • type II fibronectin collagen-binding domain motif
  • eight C type lectin-like carbohydrate recognition, a transmembrane domains
  • a short cytoplasmic carboxyl terminus
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine lectin lambda
    Homologene
    FAMILY macrophage mannose receptor family
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • internalization of glycosylated ligands from the extracellular milieu
  • may be regulating beta-glucan synthesis
  • playing a physiological role in mediating collagen matrix remodelling during tissue development and homeostasis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • collagen V
  • N-acetylglucosamine
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS