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FLASH GENE
Symbol MRC2 contributors: - updated : 05-07-2005
HGNC name mannose receptor, C type 2
HGNC id 16875
Location 17q21.1-q23      Physical location : 60.704.761 - 60.770.950
Synonym name
  • urokinase plasminogen activator receptor-associated protein
  • endocytic receptor (macrophage mannose receptor family)
  • likely ortholog of mouse mannose receptor, C type 2
    • Synonym symbol(s) KIAA0709, ENDO180, UPARAP
    DNA
    TYPE functioning gene
    STRUCTURE 67.00 kb     30 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Connective    
    Epithelialbarrier/liningepidermis  
    Epithelialbarrier/liningendometrium  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    Lymphoid/Immunemacrophage
    Muscularmyoblast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • large extracellular domain contains an N-terminal cysteine-rich domain
  • type II fibronectin collagen-binding domain motif
  • eight C type lectin-like carbohydrate recognition, a transmembrane domains
  • a short cytoplasmic carboxyl terminus
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine lectin lambda
    Homologene
    FAMILY macrophage mannose receptor family
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • internalization of glycosylated ligands from the extracellular milieu
  • may be regulating beta-glucan synthesis
  • playing a physiological role in mediating collagen matrix remodelling during tissue development and homeostasis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • collagen V
  • N-acetylglucosamine
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS