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FLASH GENE
Symbol ACSBG1 contributors: mct - updated : 27-12-2021
HGNC name acyl-CoA synthetase bubblegum family member 1
HGNC id 29567
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to Drosophila lipidosin
homolog to murine Acsbg1
intraspecies homolog to mycobacterium T long-chain-fatty-acid CoA ligase
Homologene
FAMILY
  • ATP-dependent AMP-binding enzyme family
  • bubblegum subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • long-chain acyl-CoA synthetase activity
  • playing a central role in brain very long-chain fatty acids metabolism and myelinogenesis
  • ACSBG1, ACSBG2 are ACSBG gene family which activates, Fatty acids (FAs) with >16 carbons
  • acyl-CoA synthetase, being the key pro-ferroptotic factor in the heat-induced ferroptosis proces
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in adrenoleukodystrophy
    tumoral        
    aberrant promoter methylation might be involved in its silencing/expression in malignant pheochromocytoma (PCC) and paraganglioma (PGL)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS