Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

DDIT3

contributors: npt/shn - updated : 08-06-2015

HGNC name	DNA-damage-inducible transcript 3
HGNC id	2726

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

DDIT3

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     translocated with FUS in t(12;16)(q13;p11) and with ESWR1 in t(12;22)(q13;q12) in myxoid liposarcoma constitutional       loss of function in conjunction with a COMP mutation, may lead to aggravation of the skeletal phenotype via a potentially synergistic effect on endochondral ossification

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete     therapeutic potential of CHOP inhibition in the management of diabetic cardiovascular complications including diabetic cardiomyopathy digestive liver   targeting DDIT3/ERO1A signalling could be a novel therapeutic approach during acute liver failure (ALF)

ANIMAL & CELL MODELS

Chop-null mice are resistant to fibrosis, which is a key risk factor for hepatocellular carcinoma (HCC)