| 1 | DDIT3, EIF2AK3, ELANE
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| Human neutrophil elastase induces endothelial cell apoptosis by activating the PERK-CHOP branch of the unfolded protein response.
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| Grechowa I, Horke S, Wallrath A, Vahl CF, Dorweiler B.
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| FASEB J 31(9):3868-3881. doi: 10.1096/fj.201700012R. Epub 2017 May 15.
2017
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| 2 | DDIT3, NR1H4
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| FXR controls CHOP expression in steatohepatitis.
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| Fuchs CD, Claudel T, Scharnagl H, Stojakovic T, Trauner M.
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| FEBS Lett 591(20):3360-3368. doi: 10.1002/1873-3468.12845. Epub 2017 Oct 11.
2017
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| 3 | DDIT3
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| CHOP deficiency prevents methylglyoxal-induced myocyte apoptosis and cardiac dysfunction.
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| Nam DH, Han JH, Lee TJ, Shishido T, Lim JH, Kim GY, Woo CH.
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| J Mol Cell Cardiol Mol Cell Cardiol. 2015 May 28. pii: S0022-2828(15)00168-6. doi: 10.1016/j.yjmcc.2015.05.016. [Epub ahead of print]
2015
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| 4 | DDIT3, IRAK2
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| CHOP Links Endoplasmic Reticulum Stress to NF-κB Activation in the Pathogenesis of Nonalcoholic Steatohepatitis.
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| Willy JA, Young SK, Stevens JL, Masuoka HC, Wek RC.
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| Mol Biol Cell ol Biol Cell. 2015 Apr 22. pii: mbc.E15-01-0036. [Epub ahead of print] 2015
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| 5 | DDIT3, ERO1A
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| C/EBP homologous protein (CHOP) contributes to hepatocyte death via the promotion of ERO1α signalling in acute liver failure.
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| Rao J, Zhang C, Wang P, Lu L, Qian X, Qin J, Pan X, Li G, Wang X, Zhang F.
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| Biochem J 466(2):369-78. doi: 10.1042/BJ20140412.
2015
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| 6 | BIRC5, DDIT3, NR4A1
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| The Orphan Nuclear Receptor NR4A1 Protects Pancreatic β-Cells from Endoplasmic Reticulum (ER) Stress-mediated Apoptosis.
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| Yu C, Cui S, Zong C, Gao W, Xu T, Gao P, Chen J, Qin D, Guan Q, Liu Y, Fu Y, Li X, Wang X.
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| J Biol Chem 290(34):20687-99. doi: 10.1074/jbc.M115.654863. Epub 2015 Jul 8.
2015
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| 7 | DDIT3, KAT2A, TNFRSF10A, TNFRSF10B
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| DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells.
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| Li T, Su L, Lei Y, Liu X, Zhang Y, Liu X.
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| J Biol Chem. Apr 24;290(17):11108-18. doi: 10.1074/jbc.M115.645333. Epub 2015 Mar 13. 2015
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| 8 | DDIT3
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| Endoplasmic reticulum stress effector CCAAT/enhancer-binding protein homologous protein (CHOP) regulates chronic kidney disease-induced vascular calcification.
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| Miyazaki-Anzai S, Masuda M, Demos-Davies KM, Keenan AL, Saunders SJ, Masuda R, Jablonski K, Cavasin MA, Kendrick J, Chonchol M, McKinsey TA, Levi M, Miyazaki M.
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| J Am Heart Assoc 3(3):e000949. doi: 10.1161/JAHA.114.000949.
2014
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| 9 | DDIT3, FGF21
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| ATF4- and CHOP-dependent induction of FGF21 through endoplasmic reticulum stress.
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| Wan XS, Lu XH, Xiao YC, Lin Y, Zhu H, Ding T, Yang Y, Huang Y, Zhang Y, Liu YL, Xu ZM, Xiao J, Li XK.
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| Biomed Res Int 2014:807874. doi: 10.1155/2014/807874. Epub 2014 May 11.
2014
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| 10 | DDIT3
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| Inactivation of C/ebp homologous protein-driven immune-metabolic interactions exacerbate obesity and adipose tissue leukocytosis.
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| Grant R, Nguyen KY, Ravussin A, Albarado D, Youm YH, Dixit VD.
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| J Biol Chem 289(20):14045-55. doi: 10.1074/jbc.M113.545921. Epub 2014 Mar 24.
2014
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| 11 | DDIT3
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| Abnormal chondrocyte apoptosis in the cartilage growth plate is influenced by genetic background and deletion of CHOP in a targeted mouse model of pseudoachondroplasia.
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| Piróg KA, Irman A, Young S, Halai P, Bell PA, Boot-Handford RP, Briggs MD.
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| PLoS One 9(2):e85145. doi: 10.1371/journal.pone.0085145. eCollection 2014.
2014
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| 12 | BCL2L1, DDIT3
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| Bcl-xL protein protects from C/EBP homologous protein (CHOP)-dependent apoptosis during plasma cell differentiation.
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| Gaudette BT, Iwakoshi NN, Boise LH.
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| J Biol Chem 289(34):23629-40. doi: 10.1074/jbc.M114.569376. Epub 2014 Jul 14.
2014
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| 13 | CEBPA, DDIT3, PPARA, SREBF1
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| C/EBP homologous protein (CHOP) contributes to suppression of metabolic genes during endoplasmic reticulum stress in the liver.
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| Chikka MR, McCabe DD, Tyra HM, Rutkowski DT.
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| J Biol Chem 288(6):4405-15. doi: 10.1074/jbc.M112.432344. Epub 2012 Dec 31.
2013
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| 14 | DDIT3
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| The stress-regulated transcription factor CHOP promotes hepatic inflammatory gene expression, fibrosis, and oncogenesis.
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| DeZwaan-McCabe D, Riordan JD, Arensdorf AM, Icardi MS, Dupuy AJ, Rutkowski DT.
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| PLoS Genet 9(12):e1003937. doi: 10.1371/journal.pgen.1003937. Epub 2013 Dec 19.
2013
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| 15 | DDIT3
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| CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis.
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| Teske BF, Fusakio ME, Zhou D, Shan J, McClintick JN, Kilberg MS, Wek RC.
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| Mol Biol Cell 24(15):2477-90. doi: 10.1091/mbc.E13-01-0067. Epub 2013 Jun 12.
2013
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| 16 | ATF5, DDIT3
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| CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis.
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| Teske BF, Fusakio ME, Zhou D, Shan J, McClintick JN, Kilberg MS, Wek RC.
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| Mol Biol Cell 24(15):2477-90. doi: 10.1091/mbc.E13-01-0067. Epub 2013 Jun 12.
2013
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| 17 | DDIT3
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| CHOP-mediated hepcidin suppression modulates hepatic iron load.
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| Mueller K, Sunami Y, Stuetzle M, Guldiken N, Kucukoglu O, Mueller S, Kulaksiz H, Schwarz P, Strnad P.
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| J Pathol 231(4):532-42. doi: 10.1002/path.4221. Epub 2013 Oct 15.
2013
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| 18 | DDIT3, FAM129A, STT3A
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| The new molecular markers DDIT3, STT3A, ARG2 and FAM129A are not useful in diagnosing thyroid follicular tumors.
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| Sigstad E, Paus E, Bjøro T, Berner A, Grøholt KK, Jørgensen LH, Sobrinho-Simões M, Holm R, Warren DJ.
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| Mod Pathol 25(4):537-47. doi: 10.1038/modpathol.2011.188. Epub 2011 Dec 9.
2012
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| 19 | DDIT3, LCN2
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| Lipocalin 2, a new GADD153 target gene, as an apoptosis inducer of endoplasmic reticulum stress in lung cancer cells.
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| Hsin IL, Hsiao YC, Wu MF, Jan MS, Tang SC, Lin YW, Hsu CP, Ko JL.
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| Toxicol Appl Pharmacol 263(3):330-7. doi: 10.1016/j.taap.2012.07.005. Epub 2012 Jul 16.
2012
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| 20 | DDIT3, EWSR1
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| Myxoid liposarcoma-associated EWSR1-DDIT3 selectively represses osteoblastic and chondrocytic transcription in multipotent mesenchymal cells.
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| Suzuki K, Matsui Y, Higashimoto M, Kawaguchi Y, Seki S, Motomura H, Hori T, Yahara Y, Kanamori M, Kimura T.
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| PLoS One 7(5):e36682. doi: 10.1371/journal.pone.0036682. Epub 2012 May 3.
2012
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| 21 | BRSK1, BRSK2, DDIT3
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| BRSK2 is regulated by ER stress in protein level and involved in ER stress-induced apoptosis.
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| Wang Y, Wan B, Li D, Zhou J, Li R, Bai M, Chen F, Yu L.
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| Biochem Biophys Res Commun 423(4):813-8. doi: 10.1016/j.bbrc.2012.06.046. Epub 2012 Jun 16. Erratum in: Biochem Biophys Res Commun. 2012 Oct 5;426(4):667.
2012
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| 22 | DDIT3, RNASEL
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| RNase L controls terminal adipocyte differentiation, lipids storage and insulin sensitivity via CHOP10 mRNA regulation.
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| Fabre O, Salehzada T, Lambert K, Boo Seok Y, Zhou A, Mercier J, Bisbal C.
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| Cell Death Differ 19(9):1470-81. doi: 10.1038/cdd.2012.23.
2012
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| 23 | BMP2, DDIT3, EIF2AK3, PARM1
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| PARM-1 promotes cardiomyogenic differentiation through regulating the BMP/Smad signaling pathway.
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| Nakanishi N, Takahashi T, Ogata T, Adachi A, Imoto-Tsubakimoto H, Ueyama T, Matsubara H.
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| Biochem Biophys Res Commun 428(4):500-5. doi: 10.1016/j.bbrc.2012.10.078. Epub 2012 Nov 1.
2012
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| 24 | ATF4, BBC3, DDIT3
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| Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA.
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| Galehdar Z, Swan P, Fuerth B, Callaghan SM, Park DS, Cregan SP.
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| J Neurosci. 30(50):16938-48. 2010
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| 25 | DDIT3, DHPS
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| Inhibition of deoxyhypusine synthase enhances islet {beta} cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetes.
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| Robbins RD, Tersey SA, Ogihara T, Gupta D, Farb TB, Ficorilli J, Bokvist K, Maier B, Mirmira RG.
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| J Biol Chem 285(51):39943-52. doi: 10.1074/jbc.M110.170142. Epub 2010 Oct 18.
2010
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| 26 | DDIT3, FUS, NFKBIZ
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| The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ.
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| Göransson M, Andersson MK, Forni C, Ståhlberg A, Andersson C, Olofsson A, Mantovani R, Aman P.
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| Oncogene 28(2):270-8. Epub 2008 Oct 13.
2009
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| 27 | DDIT3, JDP2
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| Role of the repressor JDP2 in the amino acid-regulated transcription of CHOP.
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| Chérasse Y, Chaveroux C, Jousse C, Maurin AC, Carraro V, Parry L, Fafournoux P, Bruhat A.
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| FEBS Lett 582(10):1537-41. Epub 2008 Apr 7. 2008
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| 28 | DDIT3
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| The molecular regulation of GADD153 in apoptosis of cultured vascular smooth muscle cells by cyclic mechanical stretch.
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| Cheng WP, Hung HF, Wang BW, Shyu KG.
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| Cardiovasc Res 77(3):551-9. Epub 2007 Oct 30.PMID: 18006442 2008
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| 29 | ATF4, DDIT3, KAT2B
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| The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP.
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| Cherasse Y, Maurin AC, Chaveroux C, Jousse C, Carraro V, Parry L, Deval C, Chambon C, Fafournoux P, Bruhat A.
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| Nucleic Acids Res 35(17):5954-65. Epub 2007 Aug 28. 2007
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| 30 | EWSR, DDIT3
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| Relevance of translocation type in myxoid liposarcoma and identification of a novel EWSR1-DDIT3 fusion.
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| Bode-Lesniewska B, Frigerio S, Exner U, Abdou MT, Moch H, Zimmermann DR.
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| Genes Chromosomes Cancer 46(11):961-71. 2007
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| 31 | TRIB3, DDIT3, ATF4
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| TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death.
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| Ohoka N, Yoshii S, Hattori T, Onozaki K, Hayashi H.
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| EMBO J 24(6):1243-55. Epub 2005 Mar 10. 2005
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| 32 | DDIT3, ZNF143, AKR1A1
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| Regulation of aldehyde reductase expression by STAF and CHOP.
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| Barski OA, Papusha VZ, Kunkel GR, Gabbay KH.
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| Genomics 83(1):119-29. 2004
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| 33 | DDIT3, CEBPA, CEBPB
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| CCAAT/enhancer binding protein homologous protein (DDIT3) induces osteoblastic cell differentiation.
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| Pereira RC, Delany AM, Canalis E.
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| Endocrinology 145(4):1952-60. Epub 2003 Dec 18. 2004
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| 34 | DDIT3
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| Protein partners of C/EBPepsilon.
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| Chih DY, Park DJ, Gross M, Idos G, Vuong PT, Hirama T, Chumakov AM, Said J, Koeffler HP.
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| Exp Hematol. 32(12):1173-81. 2004
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| 35 | DDIT3
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| CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation.
|
| Ubeda M, Habener JF.
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| J Biol Chem. 278(42):40514-20. 2003
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| 36 | COL1A1, DDIT3, EWSR1, SUZ12, JAZF1, NR4A3, WT1
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| Cytogenetics and molecular genetics of bone and soft-tissue tumors.
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| Sandberg AA.
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| Am J Med Genet 115(3):189-93. 2002
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| 37 | ATF2, DDIT3
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| The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP).
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| Gachon F, Gaudray G, Thebault S, Basbous J, Koffi JA, Devaux C, Mesnard J.
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| FEBS Lett 502(1-2):57-62. 2001
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| 38 | DDIT3
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| Regulated expression and functional role of the transcription factor CHOP (GADD153) in erythroid growth and differentiation.
|
| Coutts M, et al.
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| Blood 93(10):3369-78. 1999
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| 39 | DDIT3, JUN
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| CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins.
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| Ubeda M, Vallejo M, Habener JF.
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| Mol Cell Biol. 19(11):7589-99. 1999
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| 40 | DDIT3, ERG, EWSR1, FUS
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| Characteristic sequence motifs at the breakpoints of the hybrid genes FUS/CHOP, EWS/CHOP and FUS/ERG in myxoid liposarcoma and acute myeloid leukemia.
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| Panagopoulos I, Lassen C, Isaksson M, Mitelman F, Mandahl N, Aman P.
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| Oncogene 15(11):1357-62. 1997
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| 41 | DDIT3
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| YAC clones that extend the human chromosome 12cen-12q15 region contig map.
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| Andersen SE, et al.
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| Mamm Genome 7 : 780-783. 1996
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| 42 | ATF3, DDIT3
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| Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10.
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| Chen BP, Wolfgang CD, Hai T.
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| Mol Cell Biol. 16(3):1157-68. 1996
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| 43 | DDIT3
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| Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress.
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| Fawcett TW, Eastman HB, Martindale JL, Holbrook NJ.
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| J Biol Chem. 271(24):14285-9. 1996
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| 44 | DDIT3, ERG, FUS
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| Two distinct FUS breakpoint clusters in myxoid liposarcoma and acute myeloid leukemia with the translocations t(12;16) and t(16;21).
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| Panagopoulos I, et al.
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| oncogene 11 : 1133-1137 1995
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| 45 | LIPO, DDIT3, ULCR12
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| Identification of a YAC spanning the translocation breakpoints in uterine leiomyomata, pulmonary chondroid hamartoma, and lipoma : physical mapping of the 12q14-q15 breakpoint region in uterine leiomyomata.
|
| Schoenberg Fejzo M, et al.
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| Genomics 26 : 265-271. 1995
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| 46 | CDK4, DDIT3, GLI1, MDM2
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| Mapping of gene loci in the Q13-Q15 region of chromosome 12.
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| Mitchell ELD, et al.
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| Chromosome Res 3 : 261-262. 1995
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| 47 | DDIT3
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| A long range restriction map spanning the myxoid liposarcoma breakpoint in the q13-14 region of human chromosome 12.
|
| Forus A, et al.
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| Hum Genet 94 : 259-264. 1994
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| 48 | DDIT3
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| Rare variant (Glu to Lys) in the leucine zipper region of CHOP (GADD153).
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| Heighway J, et al.
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| Oncogene 9 : 2737-2738. 1994
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| 49 | FUS, DDIT3
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| Isolation of asomatic cell hybrid retaining the der(16)t(12;16)(q13;p11.2) from a myxoid liposarcoma cell line.
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| Schoenmakers HFPM, et al.
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| Cytogenet Cell Genet 62 : 159-161. 1993
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| 50 | DDIT3, FUS
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| Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma.
|
| Crozat A, et al.
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| Nature 363 : 640-644. 1993
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| 51 | LIPO, DDIT3
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| Chromosome 12 breakpoints are cytogenetically different in benign and malignant lipogenic tumors : localization of breakpoints in lipoma to 12q15 and in myxoid liposarcoma to 12q13.3.
|
| Mrozek K, et al.
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| Cancer Res 53 : 1670-1675. 1993
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| 52 | FUS, DDIT3
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| Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma.
|
| Rabbitts TH, et al.
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| Nat Genet 4 : 175-180. 1993
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| 53 | LIPO, DDIT3
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| The 12q13-q15 translocation breakpoints in pleomorphic adenoma and clear-cell sarcoma of tendons and aponeuroses are different from that in myxoid liposarcoma.
|
| Stenman G, et al.
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| Genes Chromosomes Cancer 7 : 178-180. 1993
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| 54 | DDIT3
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| Isolation, characterization and chromosomal localization of the human GADD153 gene.
|
| Park JS, et al.
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| Gene 116 : 259-267. 1992
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| 55 | DDIT3
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| Rearrangment of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11).
|
| Aman P, et al.
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| Genes Chromosomes Cancer 5 : 278-285. 1992
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| 56 | FUS, DDIT3
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| Myxoid liposarcoma with t(12;16)(q13;p11) contains site-specific differences in methylation patterns surrounding a zinc-finger gene mapped to the breakpoint region on chromosome 12.
|
| Paulien S, et al.
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| Cancer Res 50 : 7902-7907. 1990
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| 57 | FUS, DDIT3
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| Localization of the chromosomal breakpoints of the t(12;16) in liposarcoma to subbands 12q13.3 and 16p11.2.
|
| Eneroth M, et al.
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| Cancer Genet Cytogenet 48 : 101-107. 1990
|
| 58 | FUS, DDIT3
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| Translocation t(12;16) in a case of myxoid liposarcoma.
|
| Smith S, et al.
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| Cancer Genet Cytogenet 26 : 185-186. 1987
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| 59 | FUS, DDIT3
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| Cytogenetic studies of adipose tissue tumors. II.Recurrent reciprocal translocation t(12;16)(q13;p11) in myxoid liposarcomas.
|
| Turc-Carel C, et al.
|
| Cancer Genet Cytogenet 23 : 291-299. 1986
|