Citations for
1DDIT3, EIF2AK3, ELANE
Human neutrophil elastase induces endothelial cell apoptosis by activating the PERK-CHOP branch of the unfolded protein response.
Grechowa I, Horke S, Wallrath A, Vahl CF, Dorweiler B.
FASEB J 31(9):3868-3881. doi: 10.1096/fj.201700012R. Epub 2017 May 15. 2017
2DDIT3, NR1H4
FXR controls CHOP expression in steatohepatitis.
Fuchs CD, Claudel T, Scharnagl H, Stojakovic T, Trauner M.
FEBS Lett 591(20):3360-3368. doi: 10.1002/1873-3468.12845. Epub 2017 Oct 11. 2017
3DDIT3
CHOP deficiency prevents methylglyoxal-induced myocyte apoptosis and cardiac dysfunction.
Nam DH, Han JH, Lee TJ, Shishido T, Lim JH, Kim GY, Woo CH.
J Mol Cell Cardiol Mol Cell Cardiol. 2015 May 28. pii: S0022-2828(15)00168-6. doi: 10.1016/j.yjmcc.2015.05.016. [Epub ahead of print] 2015
4DDIT3, IRAK2
CHOP Links Endoplasmic Reticulum Stress to NF-κB Activation in the Pathogenesis of Nonalcoholic Steatohepatitis.
Willy JA, Young SK, Stevens JL, Masuoka HC, Wek RC.
Mol Biol Cell ol Biol Cell. 2015 Apr 22. pii: mbc.E15-01-0036. [Epub ahead of print] 2015
5DDIT3, ERO1A
C/EBP homologous protein (CHOP) contributes to hepatocyte death via the promotion of ERO1α signalling in acute liver failure.
Rao J, Zhang C, Wang P, Lu L, Qian X, Qin J, Pan X, Li G, Wang X, Zhang F.
Biochem J 466(2):369-78. doi: 10.1042/BJ20140412. 2015
6BIRC5, DDIT3, NR4A1
The Orphan Nuclear Receptor NR4A1 Protects Pancreatic β-Cells from Endoplasmic Reticulum (ER) Stress-mediated Apoptosis.
Yu C, Cui S, Zong C, Gao W, Xu T, Gao P, Chen J, Qin D, Guan Q, Liu Y, Fu Y, Li X, Wang X.
J Biol Chem 290(34):20687-99. doi: 10.1074/jbc.M115.654863. Epub 2015 Jul 8. 2015
7DDIT3
Endoplasmic reticulum stress effector CCAAT/enhancer-binding protein homologous protein (CHOP) regulates chronic kidney disease-induced vascular calcification.
Miyazaki-Anzai S, Masuda M, Demos-Davies KM, Keenan AL, Saunders SJ, Masuda R, Jablonski K, Cavasin MA, Kendrick J, Chonchol M, McKinsey TA, Levi M, Miyazaki M.
J Am Heart Assoc 3(3):e000949. doi: 10.1161/JAHA.114.000949. 2014
8DDIT3, FGF21
ATF4- and CHOP-dependent induction of FGF21 through endoplasmic reticulum stress.
Wan XS, Lu XH, Xiao YC, Lin Y, Zhu H, Ding T, Yang Y, Huang Y, Zhang Y, Liu YL, Xu ZM, Xiao J, Li XK.
Biomed Res Int 2014:807874. doi: 10.1155/2014/807874. Epub 2014 May 11. 2014
9DDIT3
Inactivation of C/ebp homologous protein-driven immune-metabolic interactions exacerbate obesity and adipose tissue leukocytosis.
Grant R, Nguyen KY, Ravussin A, Albarado D, Youm YH, Dixit VD.
J Biol Chem 289(20):14045-55. doi: 10.1074/jbc.M113.545921. Epub 2014 Mar 24. 2014
10DDIT3
Abnormal chondrocyte apoptosis in the cartilage growth plate is influenced by genetic background and deletion of CHOP in a targeted mouse model of pseudoachondroplasia.
Pirˇg KA, Irman A, Young S, Halai P, Bell PA, Boot-Handford RP, Briggs MD.
PLoS One 9(2):e85145. doi: 10.1371/journal.pone.0085145. eCollection 2014. 2014
11BCL2L1, DDIT3
Bcl-xL protein protects from C/EBP homologous protein (CHOP)-dependent apoptosis during plasma cell differentiation.
Gaudette BT, Iwakoshi NN, Boise LH.
J Biol Chem 289(34):23629-40. doi: 10.1074/jbc.M114.569376. Epub 2014 Jul 14. 2014
12CEBPA, DDIT3, PPARA, SREBF1
C/EBP homologous protein (CHOP) contributes to suppression of metabolic genes during endoplasmic reticulum stress in the liver.
Chikka MR, McCabe DD, Tyra HM, Rutkowski DT.
J Biol Chem 288(6):4405-15. doi: 10.1074/jbc.M112.432344. Epub 2012 Dec 31. 2013
13DDIT3
The stress-regulated transcription factor CHOP promotes hepatic inflammatory gene expression, fibrosis, and oncogenesis.
DeZwaan-McCabe D, Riordan JD, Arensdorf AM, Icardi MS, Dupuy AJ, Rutkowski DT.
PLoS Genet 9(12):e1003937. doi: 10.1371/journal.pgen.1003937. Epub 2013 Dec 19. 2013
14DDIT3
CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis.
Teske BF, Fusakio ME, Zhou D, Shan J, McClintick JN, Kilberg MS, Wek RC.
Mol Biol Cell 24(15):2477-90. doi: 10.1091/mbc.E13-01-0067. Epub 2013 Jun 12. 2013
15ATF5, DDIT3
CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis.
Teske BF, Fusakio ME, Zhou D, Shan J, McClintick JN, Kilberg MS, Wek RC.
Mol Biol Cell 24(15):2477-90. doi: 10.1091/mbc.E13-01-0067. Epub 2013 Jun 12. 2013
16DDIT3
CHOP-mediated hepcidin suppression modulates hepatic iron load.
Mueller K, Sunami Y, Stuetzle M, Guldiken N, Kucukoglu O, Mueller S, Kulaksiz H, Schwarz P, Strnad P.
J Pathol 231(4):532-42. doi: 10.1002/path.4221. Epub 2013 Oct 15. 2013
17DDIT3, FAM129A, STT3A
The new molecular markers DDIT3, STT3A, ARG2 and FAM129A are not useful in diagnosing thyroid follicular tumors.
Sigstad E, Paus E, Bj°ro T, Berner A, Gr°holt KK, J°rgensen LH, Sobrinho-Sim§es M, Holm R, Warren DJ.
Mod Pathol 25(4):537-47. doi: 10.1038/modpathol.2011.188. Epub 2011 Dec 9. 2012
18DDIT3, LCN2
Lipocalin 2, a new GADD153 target gene, as an apoptosis inducer of endoplasmic reticulum stress in lung cancer cells.
Hsin IL, Hsiao YC, Wu MF, Jan MS, Tang SC, Lin YW, Hsu CP, Ko JL.
Toxicol Appl Pharmacol 263(3):330-7. doi: 10.1016/j.taap.2012.07.005. Epub 2012 Jul 16. 2012
19DDIT3, EWSR1
Myxoid liposarcoma-associated EWSR1-DDIT3 selectively represses osteoblastic and chondrocytic transcription in multipotent mesenchymal cells.
Suzuki K, Matsui Y, Higashimoto M, Kawaguchi Y, Seki S, Motomura H, Hori T, Yahara Y, Kanamori M, Kimura T.
PLoS One 7(5):e36682. doi: 10.1371/journal.pone.0036682. Epub 2012 May 3. 2012
20BRSK1, BRSK2, DDIT3
BRSK2 is regulated by ER stress in protein level and involved in ER stress-induced apoptosis.
Wang Y, Wan B, Li D, Zhou J, Li R, Bai M, Chen F, Yu L.
Biochem Biophys Res Commun 423(4):813-8. doi: 10.1016/j.bbrc.2012.06.046. Epub 2012 Jun 16. Erratum in: Biochem Biophys Res Commun. 2012 Oct 5;426(4):667. 2012
21DDIT3, RNASEL
RNase L controls terminal adipocyte differentiation, lipids storage and insulin sensitivity via CHOP10 mRNA regulation.
Fabre O, Salehzada T, Lambert K, Boo Seok Y, Zhou A, Mercier J, Bisbal C.
Cell Death Differ 19(9):1470-81. doi: 10.1038/cdd.2012.23. 2012
22BMP2, DDIT3, EIF2AK3, PARM1
PARM-1 promotes cardiomyogenic differentiation through regulating the BMP/Smad signaling pathway.
Nakanishi N, Takahashi T, Ogata T, Adachi A, Imoto-Tsubakimoto H, Ueyama T, Matsubara H.
Biochem Biophys Res Commun 428(4):500-5. doi: 10.1016/j.bbrc.2012.10.078. Epub 2012 Nov 1. 2012
23ATF4, BBC3, DDIT3
Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA.
Galehdar Z, Swan P, Fuerth B, Callaghan SM, Park DS, Cregan SP.
J Neurosci. 30(50):16938-48. 2010
24DDIT3, DHPS
Inhibition of deoxyhypusine synthase enhances islet {beta} cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetes.
Robbins RD, Tersey SA, Ogihara T, Gupta D, Farb TB, Ficorilli J, Bokvist K, Maier B, Mirmira RG.
J Biol Chem 285(51):39943-52. doi: 10.1074/jbc.M110.170142. Epub 2010 Oct 18. 2010
25DDIT3, FUS, NFKBIZ
The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ.
G÷ransson M, Andersson MK, Forni C, Stňhlberg A, Andersson C, Olofsson A, Mantovani R, Aman P.
Oncogene 28(2):270-8. Epub 2008 Oct 13. 2009
26DDIT3, JDP2
Role of the repressor JDP2 in the amino acid-regulated transcription of CHOP.
ChÚrasse Y, Chaveroux C, Jousse C, Maurin AC, Carraro V, Parry L, Fafournoux P, Bruhat A.
FEBS Lett 582(10):1537-41. Epub 2008 Apr 7. 2008
27DDIT3
The molecular regulation of GADD153 in apoptosis of cultured vascular smooth muscle cells by cyclic mechanical stretch.
Cheng WP, Hung HF, Wang BW, Shyu KG.
Cardiovasc Res 77(3):551-9. Epub 2007 Oct 30.PMID: 18006442 2008
28ATF4, DDIT3, KAT2B
The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP.
Cherasse Y, Maurin AC, Chaveroux C, Jousse C, Carraro V, Parry L, Deval C, Chambon C, Fafournoux P, Bruhat A.
Nucleic Acids Res 35(17):5954-65. Epub 2007 Aug 28. 2007
29EWSR, DDIT3
Relevance of translocation type in myxoid liposarcoma and identification of a novel EWSR1-DDIT3 fusion.
Bode-Lesniewska B, Frigerio S, Exner U, Abdou MT, Moch H, Zimmermann DR.
Genes Chromosomes Cancer 46(11):961-71. 2007
30TRIB3, DDIT3, ATF4
TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death.
Ohoka N, Yoshii S, Hattori T, Onozaki K, Hayashi H.
EMBO J 24(6):1243-55. Epub 2005 Mar 10. 2005
31DDIT3, ZNF143, AKR1A1
Regulation of aldehyde reductase expression by STAF and CHOP.
Barski OA, Papusha VZ, Kunkel GR, Gabbay KH.
Genomics 83(1):119-29. 2004
32DDIT3, CEBPA, CEBPB
CCAAT/enhancer binding protein homologous protein (DDIT3) induces osteoblastic cell differentiation.
Pereira RC, Delany AM, Canalis E.
Endocrinology 145(4):1952-60. Epub 2003 Dec 18. 2004
33DDIT3
Protein partners of C/EBPepsilon.
Chih DY, Park DJ, Gross M, Idos G, Vuong PT, Hirama T, Chumakov AM, Said J, Koeffler HP.
Exp Hematol. 32(12):1173-81. 2004
34DDIT3
CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation.
Ubeda M, Habener JF.
J Biol Chem. 278(42):40514-20. 2003
35COL1A1, DDIT3, EWSR1, SUZ12, JAZF1, NR4A3, WT1
Cytogenetics and molecular genetics of bone and soft-tissue tumors.
Sandberg AA.
Am J Med Genet 115(3):189-93. 2002
36ATF2, DDIT3
The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP).
Gachon F, Gaudray G, Thebault S, Basbous J, Koffi JA, Devaux C, Mesnard J.
FEBS Lett 502(1-2):57-62. 2001
37DDIT3
Regulated expression and functional role of the transcription factor CHOP (GADD153) in erythroid growth and differentiation.
Coutts M, et al.
Blood 93(10):3369-78. 1999
38DDIT3, JUN
CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins.
Ubeda M, Vallejo M, Habener JF.
Mol Cell Biol. 19(11):7589-99. 1999
39DDIT3, ERG, EWSR1, FUS
Characteristic sequence motifs at the breakpoints of the hybrid genes FUS/CHOP, EWS/CHOP and FUS/ERG in myxoid liposarcoma and acute myeloid leukemia.
Panagopoulos I, Lassen C, Isaksson M, Mitelman F, Mandahl N, Aman P.
Oncogene 15(11):1357-62. 1997
40DDIT3
YAC clones that extend the human chromosome 12cen-12q15 region contig map.
Andersen SE, et al.
Mamm Genome 7 : 780-783. 1996
41ATF3, DDIT3
Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10.
Chen BP, Wolfgang CD, Hai T.
Mol Cell Biol. 16(3):1157-68. 1996
42DDIT3
Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress.
Fawcett TW, Eastman HB, Martindale JL, Holbrook NJ.
J Biol Chem. 271(24):14285-9. 1996
43DDIT3, ERG, FUS
Two distinct FUS breakpoint clusters in myxoid liposarcoma and acute myeloid leukemia with the translocations t(12;16) and t(16;21).
Panagopoulos I, et al.
oncogene 11 : 1133-1137 1995
44LIPO, DDIT3, ULCR12
Identification of a YAC spanning the translocation breakpoints in uterine leiomyomata, pulmonary chondroid hamartoma, and lipoma : physical mapping of the 12q14-q15 breakpoint region in uterine leiomyomata.
Schoenberg Fejzo M, et al.
Genomics 26 : 265-271. 1995
45CDK4, DDIT3, GLI1, MDM2
Mapping of gene loci in the Q13-Q15 region of chromosome 12.
Mitchell ELD, et al.
Chromosome Res 3 : 261-262. 1995
46DDIT3
A long range restriction map spanning the myxoid liposarcoma breakpoint in the q13-14 region of human chromosome 12.
Forus A, et al.
Hum Genet 94 : 259-264. 1994
47DDIT3
Rare variant (Glu to Lys) in the leucine zipper region of CHOP (GADD153).
Heighway J, et al.
Oncogene 9 : 2737-2738. 1994
48FUS, DDIT3
Isolation of asomatic cell hybrid retaining the der(16)t(12;16)(q13;p11.2) from a myxoid liposarcoma cell line.
Schoenmakers HFPM, et al.
Cytogenet Cell Genet 62 : 159-161. 1993
49DDIT3, FUS
Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma.
Crozat A, et al.
Nature 363 : 640-644. 1993
50LIPO, DDIT3
Chromosome 12 breakpoints are cytogenetically different in benign and malignant lipogenic tumors : localization of breakpoints in lipoma to 12q15 and in myxoid liposarcoma to 12q13.3.
Mrozek K, et al.
Cancer Res 53 : 1670-1675. 1993
51FUS, DDIT3
Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma.
Rabbitts TH, et al.
Nat Genet 4 : 175-180. 1993
52LIPO, DDIT3
The 12q13-q15 translocation breakpoints in pleomorphic adenoma and clear-cell sarcoma of tendons and aponeuroses are different from that in myxoid liposarcoma.
Stenman G, et al.
Genes Chromosomes Cancer 7 : 178-180. 1993
53DDIT3
Isolation, characterization and chromosomal localization of the human GADD153 gene.
Park JS, et al.
Gene 116 : 259-267. 1992
54DDIT3
Rearrangment of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11).
Aman P, et al.
Genes Chromosomes Cancer 5 : 278-285. 1992
55FUS, DDIT3
Myxoid liposarcoma with t(12;16)(q13;p11) contains site-specific differences in methylation patterns surrounding a zinc-finger gene mapped to the breakpoint region on chromosome 12.
Paulien S, et al.
Cancer Res 50 : 7902-7907. 1990
56FUS, DDIT3
Localization of the chromosomal breakpoints of the t(12;16) in liposarcoma to subbands 12q13.3 and 16p11.2.
Eneroth M, et al.
Cancer Genet Cytogenet 48 : 101-107. 1990
57FUS, DDIT3
Translocation t(12;16) in a case of myxoid liposarcoma.
Smith S, et al.
Cancer Genet Cytogenet 26 : 185-186. 1987
58FUS, DDIT3
Cytogenetic studies of adipose tissue tumors. II.Recurrent reciprocal translocation t(12;16)(q13;p11) in myxoid liposarcomas.
Turc-Carel C, et al.
Cancer Genet Cytogenet 23 : 291-299. 1986