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	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

CBL

contributors: mct/npt - updated : 21-08-2015

HGNC name	Cas-Br-M (murine) ecotropic retroviral transforming sequence
HGNC id	1541

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

NS7 , CBLS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       with MLL in acute myeloid leukemia (amino-terminal region of MLL to the proline-rich regions and the ubiquitin -associated leucine zipper domain of CBL) tumoral somatic mutation     gain of function in myeloid neoplasms tumoral germinal mutation       associated with juvenile myelomonocytic leukaemia

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer bone   increasing CBL expression reduces osteosarcoma cell growth, survival, and metastasis in part through downregulation of RTKs (receptor tyrosine kinase), which supports the potential therapeutic interest of targeting CBL in malignant bone diseases involvin

ANIMAL & CELL MODELS