| 1 | CBL, SMAD7
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| Smad7 modulates EGFR turnover through sequestration of c-Cbl.
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| Ha Thi HT, Kim HY, Choi SW, Kang JM, Kim SJ, Hong S.
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| Mol Cell Biol ol Cell Biol. 2015 Jun 8. pii: MCB.00274-15. [Epub ahead of print]
2015
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| 2 | CBL, LCK
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| Regulation of T cell development by c-Cbl: essential role of Lck.
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| Chiang YJ, Hodes RJ.
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| Int Immunol 27(5):245-51. doi: 10.1093/intimm/dxu105. Epub 2014 Dec 4.
2015
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| 3 | ARHGEF6, CBL, EGFR
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| αPIX Is a Trafficking Regulator that Balances Recycling and Degradation of the Epidermal Growth Factor Receptor.
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| Kortüm F, Harms FL, Hennighausen N, Rosenberger G.
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| PLoS One 10(7):e0132737. doi: 10.1371/journal.pone.0132737.
2015
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| 4 | CBL, CBLB, SIRT2
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| Cbl regulates the activity of SIRT2.
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| Choi YH, Kim H, Han Y, Jin YH, Lee KY.
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| Biochem Biophys Res Commun 453(3):557-62. doi: 10.1016/j.bbrc.2014.09.125. Epub 2014 Oct 5.
2014
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| 5 | ARHGEF6, CBL
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| c-Cbl regulates αPix-mediated cell migration and invasion.
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| Seong MW, Park JH, Yoo HM, Yang SW, Oh KH, Ka SH, Park DE, Lee ST, Chung CH.
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| Biochem Biophys Res Commun 455(3-4):153-8. doi: 10.1016/j.bbrc.2014.10.129.
2014
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| 6 | CBL, CD5
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| The carboxy-terminal region of CD5 is required for c-CBL mediated TCR signaling downmodulation in thymocytes.
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| Roa NS, Ordoñez-Rueda D, Chávez-Rios JR, Raman C, García-Zepeda EA, Lozano F, Soldevila G.
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| Biochem Biophys Res Commun 432(1):52-9. doi: 10.1016/j.bbrc.2013.01.086. Epub 2013 Jan 30.
2013
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| 7 | CBL, PTK6
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| PTK6 promotes degradation of c-Cbl through PTK6-mediated phosphorylation.
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| Kang SA, Lee ST.
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| Biochem Biophys Res Commun 431(4):734-9. doi: 10.1016/j.bbrc.2013.01.046. Epub 2013 Jan 23.
2013
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| 8 | CBL, RUNX2, STAT5A
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| Promotion of osteoblast differentiation in mesenchymal cells through Cbl-mediated control of STAT5 activity.
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| Dieudonne FX, Sévère N, Biosse-Duplan M, Weng JJ, Su Y, Marie PJ.
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| Stem Cells 31(7):1340-9. doi: 10.1002/stem.1380.
2013
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| 9 | CBL, EPO, EPOR, PIK3R1
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| Cbl ubiquitination of p85 is essential for Epo-induced EpoR endocytosis.
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| Bulut GB, Sulahian R, Yao H, Huang LJ.
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| Blood 122(24):3964-72. doi: 10.1182/blood-2013-05-506212. Epub 2013 Oct 10.
2013
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| 10 | BLNK, CBL, SH3KBP1
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| CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells.
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| Niiro H, Jabbarzadeh-Tabrizi S, Kikushige Y, Shima T, Noda K, Ota S, Tsuzuki H, Inoue Y, Arinobu Y, Iwasaki H, Shimoda S, Baba E, Tsukamoto H, Horiuchi T, Taniyama T, Akashi K.
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| Blood 119(10):2263-73. Epub 2012 Jan 18. 2012
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| 11 | CBL
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| Targeting the E3 ubiquitin casitas B-lineage lymphoma decreases osteosarcoma cell growth and survival and reduces tumorigenesis.
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| Sévère N, Dieudonné FX, Marty C, Modrowski D, Patiño-García A, Lecanda F, Fromigué O, Marie PJ.
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| J Bone Miner Res 27(10):2108-17. doi: 10.1002/jbmr.1667.
2012
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| 12 | CBL, CTSG
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| c-Cbl ubiquitin ligase regulates focal adhesion protein turnover and myofibril degeneration induced by neutrophil protease cathepsin G.
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| Rafiq K, Guo J, Vlasenko L, Guo X, Kolpakov MA, Sanjay A, Houser SR, Sabri A.
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| J Biol Chem 287(8):5327-39. doi: 10.1074/jbc.M111.307009. Epub 2011 Dec 27.
2012
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| 13 | CBL
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| CBL mutations in infant acute lymphoblastic leukaemia.
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| Shiba N, Park MJ, Taki T, Takita J, Hiwatari M, Kanazawa T, Sotomatsu M, Ishii E, Arakawa H, Ogawa S, Hayashi Y.
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| Br J Haematol 156(5):672-4. doi: 10.1111/j.1365-2141.2011.08900.x. Epub 2011 Oct 11. No abstract available.
2012
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| 14 | CBL, HTR2A
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| Role of c-Cbl carboxyl terminus in serotonin 5-HT2A receptor recycling and resensitization.
|
| Baldys A, Raymond JR.
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| J Biol Chem 286(28):24656-65. doi: 10.1074/jbc.M110.119891. Epub 2011 Apr 4.
2011
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| 15 | CBL
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| Tyrosine phosphorylated c-Cbl regulates platelet functional responses mediated by outside-in signaling.
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| Buitrago L, Langdon WY, Sanjay A, Kunapuli SP.
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| Blood 118(20):5631-40. doi: 10.1182/blood-2011-01-328807. Epub 2011 Oct 3.
2011
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| 16 | CBL, VHL
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| The von Hippel-Lindau tumor suppressor protein promotes c-Cbl-independent poly-ubiquitylation and degradation of the activated EGFR.
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| Zhou L, Yang H.
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| PLoS One 6(9):e23936. doi: 10.1371/journal.pone.0023936. Epub 2011 Sep 16.
2011
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| 17 | CBL
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| The E3 ligase c-Cbl regulates dendritic cell activation.
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| Chiou SH, Shahi P, Wagner RT, Hu H, Lapteva N, Seethammagari M, Sun SC, Levitt JM, Spencer DM.
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| EMBO Rep 12(9):971-9. doi: 10.1038/embor.2011.143.
2011
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| 18 | CBL, PLCG1
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| c-Cbl inhibits angiogenesis and tumor growth by suppressing activation of PLCγ1.
|
| Meyer RD, Husain D, Rahimi N.
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| Oncogene 30(19):2198-206. doi: 10.1038/onc.2010.597. Epub 2011 Jan 17.
2011
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| 19 | CBL, NS7
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| Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype.
|
| Martinelli S, De Luca A, Stellacci E, Rossi C, Checquolo S, Lepri F, Caputo V, Silvano M, Buscherini F, Consoli F, Ferrara G, Digilio MC, Cavaliere ML, van Hagen JM, Zampino G, van der Burgt I, Ferrero GB, Mazzanti L, Screpanti I, Yntema HG, Nillesen WM, Savarirayan R, Zenker M, Dallapiccola B, Gelb BD, Tartaglia M.
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| Am J Hum Genet 87(2):250-7. Epub 2010 Jul 8.PMID: 20619386 2010
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| 20 | CBL
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| Germline mutations of the CBL gene define a new genetic syndrome with predisposition to juvenile myelomonocytic leukaemia.
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| Pérez B, Mechinaud F, Galambrun C, Ben Romdhane N, Isidor B, Philip N, Derain-Court J, Cassinat B, Lachenaud J, Kaltenbach S, Salmon A, Désirée C, Pereira S, Menot ML, Royer N, Fenneteau O, Baruchel A, Chomienne C, Verloes A, Cavé H.
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| J Med Genet 47(10):686-91. Epub 2010 Jun 12.
2010
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| 21 | CBL, STAP2
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| The protein content of an adaptor protein, STAP-2 is controlled by E3 ubiquitin ligase Cbl.
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| Sekine Y, Yamamoto C, Ikeda O, Muromoto R, Nanbo A, Oritani K, Yoshimura A, Matsuda T.
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| Biochem Biophys Res Commun 384(2):187-92. Epub 2009 May 3.
2009
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| 22 | CBL
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| Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.
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| Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N, Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y, Harada H, Kurokawa M, Chiba S, Mori H, Ozawa K, Omine M, Hirai H, Nakauchi H, Koeffler HP, Ogawa S.
|
| Nature 460(7257):904-8. Epub 2009 Jul 20.PMID: 19620960 2009
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| 23 | CBL, TEK
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| Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation.
|
| Wehrle C, Van Slyke P, Dumont DJ.
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| Biochem J 423(3):375-80.PMID: 19689429 2009
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| 24 | CBL
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| Mutations in CBL occur frequently in juvenile myelomonocytic leukemia.
|
| Loh ML, Sakai DS, Flotho C, Kang M, Fliegauf M, Archambeault S, Mullighan CG, Chen L, Bergstraesser E, Bueso-Ramos CE, Emanuel PD, Hasle H, Issa JP, van den Heuvel-Eibrink MM, Locatelli F, Stary J, Trebo M, Wlodarski M, Zecca M, Shannon KM, Niemeyer CM.
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| Blood 114(9):1859-63. Epub 2009 Jul 1.PMID: 19571318 2009
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| 25 | CBL
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| Cbl negatively regulates JNK activation and cell death.
|
| Sproul AA, Xu Z, Wilhelm M, Gire S, Greene LA.
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| Cell Res 19(8):950-61.PMID: 19546888 2009
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| 26 | CBL
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| Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms.
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| Grand FH, Hidalgo-Curtis CE, Ernst T, Zoi K, Zoi C, McGuire C, Kreil S, Jones A, Score J, Metzgeroth G, Oscier D, Hall A, Brandts C, Serve H, Reiter A, Chase AJ, Cross NC.
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| Blood 113(24):6182-92. Epub 2009 Apr 22.PMID: 19387008 2009
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| 27 | CBL, CBLB
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| Loss of Cbl-b increases osteoclast bone-resorbing activity and induces osteopenia.
|
| Nakajima A, Sanjay A, Chiusaroli R, Adapala NS, Neff L, Itzsteink C, Horne WC, Baron R.
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| J Bone Miner Res 24(7):1162-72. doi: 10.1359/jbmr.090205.
2009
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| 28 | CBL, IL6ST
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| c-Cbl-dependent monoubiquitination and lysosomal degradation of gp130.
|
| Tanaka Y, Tanaka N, Saeki Y, Tanaka K, Murakami M, Hirano T, Ishii N, Sugamura K.
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| Mol Cell Biol 28(15):4805-18. Epub 2008 Jun 2.PMID: 18519587 2008
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| 29 | CBL
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| c-Cbl expression levels regulate the functional responses of human central and effector memory CD4 T cells.
|
| Brembilla NC, Weber J, Rimoldi D, Pradervand S, Schütz F, Pantaleo G, Rüegg C, Quadroni M, Harshman K, Doucey MA.
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| Blood 112(3):652-60. Epub 2008 May 27.PMID: 1850578 2008
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| 30 | CBL, TREAD1
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| TEAD1 and c-Cbl are novel prostate basal cell markers that correlate with poor clinical outcome in prostate cancer.
|
| Knight JF, Shepherd CJ, Rizzo S, Brewer D, Jhavar S, Dodson AR, Cooper CS, Eeles R, Falconer A, Kovacs G, Garrett MD, Norman AR, Shipley J, Hudson DL.
|
| Br J Cancer 99(11):1849-58. Epub 2008 Nov 11.
2008
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| 31 | CBL, SH3KBP1
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| Interactions between the three CIN85 SH3 domains and ubiquitin: implications for CIN85 ubiquitination.
|
| Bezsonova I, Bruce MC, Wiesner S, Lin H, Rotin D, Forman-Kay JD.
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| Biochemistry 47(34):8937-49. Epub 2008 Aug 5.PMID: 18680311 2008
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| 32 | CBL, LAT
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| c-Cbl-mediated regulation of LAT-nucleated signaling complexes.
|
| Balagopalan L, Barr VA, Sommers CL, Barda-Saad M, Goyal A, Isakowitz MS, Samelson LE.
|
| Mol Cell Biol 27(24):8622-36. Epub 2007 Oct 15.PMID: 17938199 2007
|
| 33 | CBL, KMT2A
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| Identification of CBL, a proto-oncogene at 11q23.3, as a novel MLL fusion partner in a patient with de novo acute myeloid leukemia.
|
| Fu JF, Hsu JJ, Tang TC, Shih LY.
|
| Genes Chromosomes Cancer 37(2):214-9. 2003
|
| 34 | CBL, CBLB, CBLC
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| Comparative genomic organization of the cbl genes.
|
| Nau MM, Lipkowitz S.
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| Gene 308:103-13. 2003
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| 35 | CBL, LCK
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| Negative regulation of Lck by Cbl ubiquitin ligase.
|
| Rao N, Miyake S, Reddi AL, Douillard P, Ghosh AK, Dodge IL, Zhou P, Fernandes ND, Band H.
|
| Proc Natl Acad Sci U S A 99(6):3794-9. 2002
|
| 36 | CBL
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| Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases.
|
| Zheng N, Wang P, Jeffrey PD, Pavletich NP.
|
| Cell 102(4):533-9. 2000
|
| 37 | CBL, FLOT1, FLOT2, LPCN, SORBS1
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| CAP defines a second signalling pathway required for insulin-stimulated glucose transport.
|
| Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR.
|
| Nature 407(6801):202-7. 2000
|
| 38 | CBL, HCK
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| The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase.
|
| Howlett CJ, et al.
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| Biochem Biophys Res Commun 257(1):129-38. 1999
|
| 39 | CBL
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| The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase.
|
| Joazeiro CA, et al.
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| Science 286(5438):309-312 1999
|
| 40 | CBL
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| c-Cbl: a regulator of T cell receptor-mediated signalling.
|
| Thien CB, et al.
|
| Immunol Cell Biol 76(5):473-82. Review 1998
|
| 41 | DEL11QD, CBL, FRA11B
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| Association of a chromosome deletion syndrome with a fragile site within the proto-oncogene CBL2.
|
| Jones C, et al.
|
| Nature 376 : 145-149. 1995
|
| 42 | FRA11B, CBL, DEL11QD
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| Physical linkage of the fragile site FRA11B and a Jacobsen syndrome chromosome deletion breakpoint in 11q23.3.
|
| Jones C, et al.
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| Hum Mol Genet 3 : 2123-2130. 1994
|
| 43 | CCLD, CBL, D11S144, CASP1, HMBS
|
| Five sequence tagged sites for human chromosome band 11q23.
|
| Perry H, et al.
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| Hum Mol Genet 2 : 614. 1993
|
| 44 | CBL
|
| The truncation that generated the v-cbl oncogene reveals an ability for nuclear transport, DNA binding and acute transformation.
|
| Blake TJ, et al.
|
| EMBO J 12 : 2017-2026. 1993
|
| 45 | EWSR1, FLI1, CBL, LIF
|
| Molecular localization of the t(11;22)(q24;q12) translocation of Ewing sarcoma by chromosomal in situ suppression hybridization.
|
| Selleri L, et al.
|
| Proc Natl Acad Sci U S A 88 : 887-891. 1991
|
| 46 | CBL
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| Relationship of the human protooncogene CBL2 on 11q23 to the t(4;11), t(11;22), and t(11;14) breakpoints.
|
| Savage PD, et al.
|
| Cytogenet Cell Genet 56 : 112-115. 1991
|
| 47 | ATM, CBL
|
| Physical mapping of the human chromosome 11q23 region containing the ataxia-telangiectasia locus.
|
| Wei S, et al.
|
| Cancer Genet Cytogenet 46 : 1-8. 1990
|
| 48 | CBL
|
| v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas.
|
| Langdon WY, et al.
|
| Proc Natl Acad Sci U S A 86 : 1168-1172. 1989
|