Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CIC

contributors: mct - updated : 19-09-2017

HGNC name	capicua homolog (Drosophila)
HGNC id	14214

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MRD45

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       to a double homeodomain gene DUX4 as a result of a recurrent chromosomal translocation t(4;19)(q35;q13) in Ewing-like sarcomas constitutional somatic mutation       CIC and FUBP1 mutations in oligodendrogliomas and in oligoastrocytomas

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer metastases   metastasis suppressor, that could potentially improve patient outcomes

ANIMAL & CELL MODELS

	underlying cardiovascular and hair follicle defects in ragged mice
	Cic-L(-/-)) mice have impaired bile acid (BA) homeostasis associated with induction of proinflammatory cytokines