Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CIC contributors: mct - updated : 19-09-2017
HGNC name capicua homolog (Drosophila)
HGNC id 14214
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Nervousbrainhindbraincerebellum predominantly
 brainlimbic systemhippocampus predominantly
 nerve   highly
Olfactory (smell)olfactory bulb   predominantly
Reproductivemale systemprostate  highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a HMG box DNA-binding domain
  • HOMOLOGY
    interspecies homolog to murine HMG-box transcription factor SOX18
    homolog to Drosophila capicua
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in cytoskeletal organization and cellular growth,exerting its effects on the cytoskeleton directly, or indirectly via proline-binding proteins (e.g. profilin) or proteins possessing SH3 domains
  • implicated in CNS development, in particular in granule cell development
  • DNA-binding protein that is a key downstream component in the pathway by which RAS regulates growth in imaginal discs
  • critical role for CIC and FUBP1 in the biology and pathology of oligodendrocytes
  • is a critical regulator of bile acid (BA) homeostasis, and its dysfunction might be associated with chronic liver disease and metabolic disorders
  • acted as an essential downstream effector of EGFR/RAS signaling, and its nuclear localization was regulated by EGFR signaling
  • controls tissue patterning and restricts organ growth
  • functions as an integrator of upstream signals that are essential for tissue patterning and organ growth
  • is a conserved metastasis suppressor
  • CIC activity in the hypothalamus and medial amygdala modulates social interactions
  • transcriptional repressor that maintains peripheral immune tolerance by suppressing aberrant activation of adaptive immunity
  • maintains T-cell homeostasis and negatively regulates TFH cell development and autoimmunity
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with ATXN1 in its native complex to cause SCA1 neuropathology
  • CIC is an ATXN1 interactor
  • cooperative effect between CIC and RB1 in promoting G1 arrest is mediated, at least in part, by limiting CCNE expression
  • ATXN1 binds to the transcriptional repressor Capicua (CIC), and the interaction plays a critical role in SCA1 pathogenesis
  • is a transcriptional repressor that is downregulated in response to RTK signaling, thereby enabling RTK-dependent induction of CIC target
  • DYRK1A may also down-regulate CIC in human cells
  • as a suppressor of tumor growth and metastasis, CIC may be an important target of the COP9 signalosome in cancer
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRD45
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    to a double homeodomain gene DUX4 as a result of a recurrent chromosomal translocation t(4;19)(q35;q13) in Ewing-like sarcomas
    constitutional somatic mutation      
    CIC and FUBP1 mutations in oligodendrogliomas and in oligoastrocytomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    metastasis suppressor, that could potentially improve patient outcomes
    ANIMAL & CELL MODELS
  • underlying cardiovascular and hair follicle defects in ragged mice
  • Cic-L(-/-)) mice have impaired bile acid (BA) homeostasis associated with induction of proinflammatory cytokines