basic FUNCTION
| involved in cytoskeletal organization and cellular growth,exerting its effects on the cytoskeleton directly, or indirectly via proline-binding proteins (e.g. profilin) or proteins possessing SH3 domains |
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implicated in CNS development, in particular in granule cell development |
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DNA-binding protein that is a key downstream component in the pathway by which RAS regulates growth in imaginal discs |
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critical role for CIC and FUBP1 in the biology and pathology of oligodendrocytes |
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is a critical regulator of bile acid (BA) homeostasis, and its dysfunction might be associated with chronic liver disease and metabolic disorders |
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acted as an essential downstream effector of EGFR/RAS signaling, and its nuclear localization was regulated by EGFR signaling |
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controls tissue patterning and restricts organ growth |
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functions as an integrator of upstream signals that are essential for tissue patterning and organ growth |
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is a conserved metastasis suppressor |
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CIC activity in the hypothalamus and medial amygdala modulates social interactions |
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transcriptional repressor that maintains peripheral immune tolerance by suppressing aberrant activation of adaptive immunity |
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maintains T-cell homeostasis and negatively regulates TFH cell development and autoimmunity |