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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

PRSS3

contributors: mct - updated : 05-07-2017

HGNC name	protease, serine, 3 (mesotrypsin)
HGNC id	9486

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in epithelial ovarian cancer (EOC) constitutional     --over   with serotonin transporter and serotonin content, are increased in small intestine of irritable bowel syndrome

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	can be used as a predictor of clinical outcome in patients with ovarian cancer and may therefore represent a new prognostic marker
Therapy target
	System Type Disorder Pubmed cancer     abolishing PRSS3 functions might be an exploitable strategy as anticancer, particularly anti-vascular, therapy cancer endocrine pancreas targeting the PRSS3 signalling pathway may be an effective and feasible approach for treatment of this lethal cancer

ANIMAL & CELL MODELS