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FLASH GENE

Symbol

PRSS3

contributors: mct - updated : 05-07-2017

HGNC name	protease, serine, 3 (mesotrypsin)
HGNC id	9486

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas       moderately Homo sapiens Nervous brain       highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell Homo sapiens Nervous astrocyte Homo sapiens Nervous glia Homo sapiens Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to C.elegans c07g1.1

Homologene

FAMILY

peptidase family S1 or trypsin family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	protease serine, cationic trypsinogen
	preferential cleavage arg-xaa and lys-xaa
	is likely involved in keratinocyte terminal differentiation
	plays an important role in the progression, metastasis and prognosis of human pancreatic cancer
	important mediator of prostate cancer progression and metastasis
	is involved in the desquamation process
	epidermal PRSS3 and CASP14 work cooperatively in PSAP processing and they thereby contribute likely to permeability barrier formation
	is an isoform of trypsin that is uniquely resistant to polypeptide trypsin inhibitors and can cleave some inhibitors rapidly
	is an atypical isoform of trypsin, the upregulation of which has been implicated in promoting tumor progression

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

digestion

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	APP/protease nexin 2 is selectively cleaved by mesotrypsin within the Kunitz protease inhibitor domain
	extra-pancreatic PRSS3 is produced by esophageal adenocarcinoma (EA) and activates likely F2RL1 in an autocrine manner (F2RL1 activation increases cancer cell proliferation, and promotes cancer cell survival)
	PRSS3 contributes to the desquamation process by activating KLKs and degrading the intrinsic KLKs' inhibitor SPINK5
	trypsin family member able to cleave proteins containing the kunitz-type domains
	TFPI2 is a direct substrate of PRSS3, which hydrolyses TFPI2 (most likely at the Kunitz-type domains) blocking its anti migratory capability

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in epithelial ovarian cancer (EOC) constitutional     --over   with serotonin transporter and serotonin content, are increased in small intestine of irritable bowel syndrome

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	can be used as a predictor of clinical outcome in patients with ovarian cancer and may therefore represent a new prognostic marker
Therapy target
	System Type Disorder Pubmed cancer     abolishing PRSS3 functions might be an exploitable strategy as anticancer, particularly anti-vascular, therapy cancer endocrine pancreas targeting the PRSS3 signalling pathway may be an effective and feasible approach for treatment of this lethal cancer

ANIMAL & CELL MODELS