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FLASH GENE
Symbol PRSS3 contributors: mct - updated : 05-07-2017
HGNC name protease, serine, 3 (mesotrypsin)
HGNC id 9486
Location 9p13.3      Physical location : 33.750.514 - 33.799.228
Synonym name
  • brain trypsinogen
  • mesotrypsin
  • pancreatic trypsinogen III
  • protease, serine, 4 (trypsin 4, brain)
  • trypsin III
  • trypsin IV
  • trypsinogen 4
    • Synonym symbol(s) TRY3, T3, MTG, PRSS4, T9, TRY4
    EC.number 3.4.21.4
    DNA
    TYPE functioning gene
    STRUCTURE 48.77 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 823 - 247 - 2015 26175157
    6 - 1160 - 261 - 2015 26175157
    5 - 1032 - 304 - 2015 26175157
    5 - 803 - 240 - 2015 26175157
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   moderately Homo sapiens
    Nervousbrain   highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    Nervousastrocyte Homo sapiens
    Nervousglia Homo sapiens
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to C.elegans c07g1.1
    Homologene
    FAMILY peptidase family S1 or trypsin family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • protease serine, cationic trypsinogen
  • preferential cleavage arg-xaa and lys-xaa
  • is likely involved in keratinocyte terminal differentiation
  • plays an important role in the progression, metastasis and prognosis of human pancreatic cancer
  • important mediator of prostate cancer progression and metastasis
  • is involved in the desquamation process
  • epidermal PRSS3 and CASP14 work cooperatively in PSAP processing and they thereby contribute likely to permeability barrier formation
  • is an isoform of trypsin that is uniquely resistant to polypeptide trypsin inhibitors and can cleave some inhibitors rapidly
  • is an atypical isoform of trypsin, the upregulation of which has been implicated in promoting tumor progression
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • APP/protease nexin 2 is selectively cleaved by mesotrypsin within the Kunitz protease inhibitor domain
  • extra-pancreatic PRSS3 is produced by esophageal adenocarcinoma (EA) and activates likely F2RL1 in an autocrine manner (F2RL1 activation increases cancer cell proliferation, and promotes cancer cell survival)
  • PRSS3 contributes to the desquamation process by activating KLKs and degrading the intrinsic KLKs' inhibitor SPINK5
  • trypsin family member able to cleave proteins containing the kunitz-type domains
  • TFPI2 is a direct substrate of PRSS3, which hydrolyses TFPI2 (most likely at the Kunitz-type domains) blocking its anti migratory capability
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in epithelial ovarian cancer (EOC)
    constitutional     --over  
    with serotonin transporter and serotonin content, are increased in small intestine of irritable bowel syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • can be used as a predictor of clinical outcome in patients with ovarian cancer and may therefore represent a new prognostic marker
    • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    abolishing PRSS3 functions might be an exploitable strategy as anticancer, particularly anti-vascular, therapy
    cancerendocrinepancreas
    targeting the PRSS3 signalling pathway may be an effective and feasible approach for treatment of this lethal cancer
    ANIMAL & CELL MODELS