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FLASH GENE

Symbol

CAT

contributors: mct - updated : 19-10-2020

HGNC name	catalase
HGNC id	1516

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CAT acatalasia
Location	11p13      Physical location : 34.460.471 - 34.493.606
Synonym symbol(s)	MGC138422, MGC138424
EC.number	1.11.1.6

DNA

TYPE	functioning gene
STRUCTURE	33.13 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	cytosine-phosphate-guanine/HTF
text structure	housekeeping gene (no TATA box, no initiator element sequence, high GC content in promoter) and a core promoter that is highly conserved among species

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	pter - LMO2 - D11S318 - D11S153 - D11S907 - CAT CAT - CD44 - D11S9 - ACP2 ACP2 - D11S33 - cen
Authors	Glaser (89), Gawin (95)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001752 13 - 2291 NP_001743 - 527 - 2019 30600457

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Homo sapiens Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic erthrocyte

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

HemoP

mono polymer

homomer , tetramer

HOMOLOGY

interspecies	ortholog to murine Cat
	ortholog to dog cat

Homologene

FAMILY

catalase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,mitochondria,interspace
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,peroxisome
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,lysosome
	intracellular,cytoplasm,cytosolic

basic FUNCTION	involved in catabolic pathway of activated oxygen species and free radical detoxification
	catalase overexpression has a protective role against UVB irradiation by preventing DNA damage mediated by the late ROS increase
	catalase is an antioxidant enzyme the activity of which is crucial for the protection against damage caused by reactive oxygen species
	heme enzymes, which catalyze decomposition of hydrogen peroxide to water and molecular oxygen
	is an important antioxidant enzyme that dismutates hydrogen peroxide into water and molecular oxygen
	catalase is a key enzyme in the metabolism of H2O2 and reactive nitrogen species, and its expression and localization is markedly altered in tumors
	major peroxisome protein, plays a critical role in removing peroxisome-generated reactive oxygen species (ROS) produced by peroxisome enzymes
	catalase plays an important role in pexophagy during nutrient deprivation
	potential therapeutic effects in nonalcoholic fatty liver disease (NAFLD) progression

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

electron transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	cofactor,
	heme group and NADP

protein	transcription factors (PPARG,POU2F1), as well as genetic, epigenetic, and posttranscriptional processes, have emerged as crucial contributors to the regulation of catalase expression (PIMID: 26117330)
	MARVELD1 interacting with CAT regulates reactive oxygen species metabolism and mediates the sensitivity to chemotherapeutic drugs in epithelial tumors of the reproductive system

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CAT

Susceptibility

to essential hypertension to noise-induced hearing loss

Variant & Polymorphism

Candidate gene	neurocognitive sequelae associated with radiation exposure can be reduced by overexpression of Mitochondrial CAT, operating through a mechanism involving the preservation of neuronal morphology
Marker
Therapy target

ANIMAL & CELL MODELS

mice devoid of catalase develop an obese, pre-diabetic phenotype