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FLASH GENE

Symbol

SFRP5

contributors: mct/npt - updated : 12-09-2016

HGNC name	secreted frizzled-related protein 5
HGNC id	10779

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function in colorectal cancer by hypermethylation tumoral     --low   by hypermethylation in primary hepatocellular carcinoma (Takagi 2008) tumoral     --low   by hypermethylation in breast cancer associated with unfavorable prognosis (Veeck 2008) tumoral     --low   CpG methylation-dependent silencing was frequently seen in gastric cancer(Nojima 2007) constitutional     --over   inhibited early B-cell differentiation in the bone marrow (BM), resulting in the accumulation of cells with a common lymphoid progenitor (CLP) phenotype constitutional     --low   in obese children, especially in those with metabolic syndrome (MetS), and negatively correlated with body mass index (BMI)

Susceptibility

Variant & Polymorphism

Candidate gene	SFRP5 methylation may be a novel DNA-based biomarker potentially useful in clinical breast cancer management (Veeck 2008)
	DNA methylation markers of Gastric cancer (GC), which may serve as useful markers that may identify a distinct subset of GC (Kang 2008)
Marker	represents a candidate for a mature adipocyte marker gene
Therapy target

ANIMAL & CELL MODELS

	mice overexpressing Sfrp5 had fewer B-lymphocytes in the peripheral blood and spleen
	mice that lack functional Sfrp5 were resistant to diet-induced obesity
	Sfrp5-deficient mice fed a high-calorie diet developed severe glucose intolerance and hepatic steatosis, and their adipose tissue showed an accumulation of activated macrophages