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FLASH GENE
Symbol SFRP5 contributors: mct/npt - updated : 12-09-2016
HGNC name secreted frizzled-related protein 5
HGNC id 10779
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral       loss of function
in colorectal cancer by hypermethylation
tumoral     --low  
by hypermethylation in primary hepatocellular carcinoma (Takagi 2008)
tumoral     --low  
by hypermethylation in breast cancer associated with unfavorable prognosis (Veeck 2008)
tumoral     --low  
CpG methylation-dependent silencing was frequently seen in gastric cancer(Nojima 2007)
constitutional     --over  
inhibited early B-cell differentiation in the bone marrow (BM), resulting in the accumulation of cells with a common lymphoid progenitor (CLP) phenotype
constitutional     --low  
in obese children, especially in those with metabolic syndrome (MetS), and negatively correlated with body mass index (BMI)
Susceptibility
Variant & Polymorphism
Candidate gene
  • SFRP5 methylation may be a novel DNA-based biomarker potentially useful in clinical breast cancer management (Veeck 2008)
  • DNA methylation markers of Gastric cancer (GC), which may serve as useful markers that may identify a distinct subset of GC (Kang 2008)
  • Marker
  • represents a candidate for a mature adipocyte marker gene
  • Therapy target
    ANIMAL & CELL MODELS
  • mice overexpressing Sfrp5 had fewer B-lymphocytes in the peripheral blood and spleen
  • mice that lack functional Sfrp5 were resistant to diet-induced obesity
  • Sfrp5-deficient mice fed a high-calorie diet developed severe glucose intolerance and hepatic steatosis, and their adipose tissue showed an accumulation of activated macrophages