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FLASH GENE
Symbol SFRP5 contributors: mct/npt - updated : 12-09-2016
HGNC name secreted frizzled-related protein 5
HGNC id 10779
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • frizzled-like cysteine-rich domain
  • a conserved hydrophilic carboxyterminal domain
    • HOMOLOGY
    interspecies homolog to Drosophila frizzled polarity
    homolog to murine Sfrp 5
    Homologene
    FAMILY
  • secreted frizzled-related protein (sFRP) family
    • CATEGORY signaling
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • likely involved in WNT binding and in determining the polarity of photoreceptors and other cells in retina
  • in the setting of obesity, SFRP5 secretion by adipocytes exerts salutary effects on metabolic dysfunction by controlling inflammatory cells within adipose tissue (pMID: 20558665)
  • may play a probable defensive role in impeding gastric cancer progression, characteristically by inhibiting gastric epithelial cells (GEC) migration induced by macrophage-derived WNT5A via JNK signaling activation
  • cellular actions of SFRP5 seem to depend on the type of tissue as well as its inflammatory and metabolic state
  • acts as a mature adipocyte marker but not as a regulator in adipogenesis
  • is a negative regulator of glucose metabolism
  • functions to antagonize inflammatory responses after ischemia/reperfusion (I/R) in the heart, possibly through a mechanism involving non-canonical WNT5A/JNK signaling
  • possible detrimental role of SFRP5 for insulin secretion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IFT88 and primary cilia regulate expression of SFRP5 and WNT signaling pathways in growth plate via regulation of IHH signaling
    • cell & other
    REGULATION
    inhibited by glucose (glucose inhibits likely SFRP5 expression via the PI3K/AKT pathway and hence promotes pancreatic beta-cell proliferation)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in colorectal cancer by hypermethylation
    tumoral     --low  
    by hypermethylation in primary hepatocellular carcinoma (Takagi 2008)
    tumoral     --low  
    by hypermethylation in breast cancer associated with unfavorable prognosis (Veeck 2008)
    tumoral     --low  
    CpG methylation-dependent silencing was frequently seen in gastric cancer(Nojima 2007)
    constitutional     --over  
    inhibited early B-cell differentiation in the bone marrow (BM), resulting in the accumulation of cells with a common lymphoid progenitor (CLP) phenotype
    constitutional     --low  
    in obese children, especially in those with metabolic syndrome (MetS), and negatively correlated with body mass index (BMI)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • SFRP5 methylation may be a novel DNA-based biomarker potentially useful in clinical breast cancer management (Veeck 2008)
  • DNA methylation markers of Gastric cancer (GC), which may serve as useful markers that may identify a distinct subset of GC (Kang 2008)
    • Marker
  • represents a candidate for a mature adipocyte marker gene
    • Therapy target
    ANIMAL & CELL MODELS
  • mice overexpressing Sfrp5 had fewer B-lymphocytes in the peripheral blood and spleen
  • mice that lack functional Sfrp5 were resistant to diet-induced obesity
  • Sfrp5-deficient mice fed a high-calorie diet developed severe glucose intolerance and hepatic steatosis, and their adipose tissue showed an accumulation of activated macrophages