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FLASH GENE
Symbol RPL26 contributors: mct/npt - updated : 12-02-2016
HGNC name ribosomal protein L26
HGNC id 10327
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • ribosomal protein L24P family
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic,ribosome
    text
  • was detected within the nucleolus-like bodys (NLB) of NSN, non-surrounded nucleolus-type oocytes but is virtually absent from NLBs of surrounded nucleolus-type oocytes
    • basic FUNCTION
  • 60S ribosomal protein L26
  • having an essential role for proliferation in all cells (Robledo 2008)
  • RPL26 modulates the HDM2-TP53 interaction by forming a ternary complex among RPL26, HDM2 and TP53, which stabilize TP53 through inhibiting the ubiquitin ligase activity of HDM2
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of ribosome, large subunit
    • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • MDM2-RPL26 interaction represents an additional important component of the autoregulatory feedback loop that dictates cellular TP53 levels and activity (Ofir-Rosenfeld 2008)
  • RPL26 was characterized as a novel HDM2-interactor
  • overexpression of RPL26 results in activating of TP53, inhibits cell proliferation and induces a TP53-dependent cell cycle arrest
  • RPL26 and NCL interact with each other and with a double-stranded RNA structure in TP53 mRNA to regulate TP53 translation after stress
  • RPL26 likely interacts with NCL and binds to TP53 mRNA in the nucleus
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS