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FLASH GENE
Symbol RPL26 contributors: mct/npt - updated : 12-02-2016
HGNC name ribosomal protein L26
HGNC id 10327
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Lymphoid/Immunetonsils   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Muscularstriatumskeletal highly
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductiveoocyte Mus musculus
cell lineage
cell lines hela cell
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • ribosomal protein L24P family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic,ribosome
    text
  • was detected within the nucleolus-like bodys (NLB) of NSN, non-surrounded nucleolus-type oocytes but is virtually absent from NLBs of surrounded nucleolus-type oocytes
  • basic FUNCTION
  • 60S ribosomal protein L26
  • having an essential role for proliferation in all cells (Robledo 2008)
  • RPL26 modulates the HDM2-TP53 interaction by forming a ternary complex among RPL26, HDM2 and TP53, which stabilize TP53 through inhibiting the ubiquitin ligase activity of HDM2
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of ribosome, large subunit
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • MDM2-RPL26 interaction represents an additional important component of the autoregulatory feedback loop that dictates cellular TP53 levels and activity (Ofir-Rosenfeld 2008)
  • RPL26 was characterized as a novel HDM2-interactor
  • overexpression of RPL26 results in activating of TP53, inhibits cell proliferation and induces a TP53-dependent cell cycle arrest
  • RPL26 and NCL interact with each other and with a double-stranded RNA structure in TP53 mRNA to regulate TP53 translation after stress
  • RPL26 likely interacts with NCL and binds to TP53 mRNA in the nucleus
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS