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FLASH GENE

Symbol

RPL26

contributors: mct/npt - updated : 12-02-2016

HGNC name	ribosomal protein L26
HGNC id	10327

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	5.73 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000987 4 - 602 NP_000978 17 145 - 2008 18697920 NM_001315530 - - 895 NP_001302459 17 145 - 2008 18697920 NM_001315531 - - 814 NP_001302460 17 145 - 2008 18697920

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Lymphoid/Immune tonsils       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly Muscular striatum skeletal   highly

cells

System Cell Pubmed Species Stage Rna symbol Reproductive oocyte Mus musculus

cell lineage
cell lines	hela cell
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

ribosomal protein L24P family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,cytosolic,ribosome
text	was detected within the nucleolus-like bodys (NLB) of NSN, non-surrounded nucleolus-type oocytes but is virtually absent from NLBs of surrounded nucleolus-type oocytes

basic FUNCTION	60S ribosomal protein L26
	having an essential role for proliferation in all cells (Robledo 2008)
	RPL26 modulates the HDM2-TP53 interaction by forming a ternary complex among RPL26, HDM2 and TP53, which stabilize TP53 through inhibiting the ubiquitin ligase activity of HDM2

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

constituent of ribosome, large subunit

INTERACTION

DNA

RNA

binding

small molecule

protein	MDM2-RPL26 interaction represents an additional important component of the autoregulatory feedback loop that dictates cellular TP53 levels and activity (Ofir-Rosenfeld 2008)
	RPL26 was characterized as a novel HDM2-interactor
	overexpression of RPL26 results in activating of TP53, inhibits cell proliferation and induces a TP53-dependent cell cycle arrest
	RPL26 and NCL interact with each other and with a double-stranded RNA structure in TP53 mRNA to regulate TP53 translation after stress
	RPL26 likely interacts with NCL and binds to TP53 mRNA in the nucleus

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS