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FLASH GENE

Symbol

PROP1

contributors: mct - updated : 03-01-2013

HGNC name	prophet of Pit1, paired-like homeodomain transcription factor
HGNC id	9455

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine neuroendocrine pituitary

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text

pituitary

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	paired-like homeo domain
	an helix-turn-helix and a paired DNA binding domains, involved in transcriptional activation

HOMOLOGY

interspecies

homolog to murine Ames dwarf (df)

Homologene

FAMILY

paired homeobox protein family (non HOX)

CATEGORY

DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	prophet of PIT1, lactotrophs, thyreotrophs and gonadotrophs, necessary for PIT1 (POU1F1) expression
	involved in the proper development of somatotrophs
	RNA polymerase 2 transcription factor involved in specification and expansion of specialized anterior pituitary cells
	important overlapping functions of HES1 and PROP1 in cell differentiation and movement that are critical for pituitary organogenesis
	regulatory role of PROP1 not only in pituitary organogenesis but also in conversion of PIT1-lineage cells
	possible transcription factor for gonadotropin subunit genes through plural cis-acting sites composed of AT-rich sequences containing a TAAT motif which differs from its consensus binding sequence
	dimeric binding of PROP1 is able to recognize diverse palindromic TAAT sequences separated by 3 nucleotides and to exhibit its transcriptional activity
	pituitary-specific factor and important for the determination of the differentiation of pituitary hormone-producing cells

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

formation of a heterodimer between HESX1 and PROP1 provides a condition in which, in the early pituitary primordium, HESX1 alters its repressive role to an active one by forming a heterodimer with newly appearing PROP1 so that PROP1 finally replaces HESX1 to advance to the middle stage of pituitary development

INTERACTION

DNA

RNA

small molecule

protein

in the presence of PROP1, HESX1 develops to bind to an inverted TAAT motif by forming a heterodimer

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CPHD2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in pituitary adenomas

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Ames dwarf