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FLASH GENE
Symbol PROP1 contributors: mct - updated : 03-01-2013
HGNC name prophet of Pit1, paired-like homeodomain transcription factor
HGNC id 9455
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text pituitary
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • paired-like homeo domain
  • an helix-turn-helix and a paired DNA binding domains, involved in transcriptional activation
  • HOMOLOGY
    interspecies homolog to murine Ames dwarf (df)
    Homologene
    FAMILY paired homeobox protein family (non HOX)
    CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • prophet of PIT1, lactotrophs, thyreotrophs and gonadotrophs, necessary for PIT1 (POU1F1) expression
  • involved in the proper development of somatotrophs
  • RNA polymerase 2 transcription factor involved in specification and expansion of specialized anterior pituitary cells
  • important overlapping functions of HES1 and PROP1 in cell differentiation and movement that are critical for pituitary organogenesis
  • regulatory role of PROP1 not only in pituitary organogenesis but also in conversion of PIT1-lineage cells
  • possible transcription factor for gonadotropin subunit genes through plural cis-acting sites composed of AT-rich sequences containing a TAAT motif which differs from its consensus binding sequence
  • dimeric binding of PROP1 is able to recognize diverse palindromic TAAT sequences separated by 3 nucleotides and to exhibit its transcriptional activity
  • pituitary-specific factor and important for the determination of the differentiation of pituitary hormone-producing cells
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • formation of a heterodimer between HESX1 and PROP1 provides a condition in which, in the early pituitary primordium, HESX1 alters its repressive role to an active one by forming a heterodimer with newly appearing PROP1 so that PROP1 finally replaces HESX1 to advance to the middle stage of pituitary development
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • in the presence of PROP1, HESX1 develops to bind to an inverted TAAT motif by forming a heterodimer
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CPHD2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pituitary adenomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Ames dwarf