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FLASH GENE
Symbol PROP1 contributors: mct - updated : 03-01-2013
HGNC name prophet of Pit1, paired-like homeodomain transcription factor
HGNC id 9455
DNA
TYPE functioning gene
STRUCTURE 4.01 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1464 - 226 - 2002 12183375
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text pituitary
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • paired-like homeo domain
  • an helix-turn-helix and a paired DNA binding domains, involved in transcriptional activation
    • HOMOLOGY
    interspecies homolog to murine Ames dwarf (df)
    Homologene
    FAMILY paired homeobox protein family (non HOX)
    CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • prophet of PIT1, lactotrophs, thyreotrophs and gonadotrophs, necessary for PIT1 (POU1F1) expression
  • involved in the proper development of somatotrophs
  • RNA polymerase 2 transcription factor involved in specification and expansion of specialized anterior pituitary cells
  • important overlapping functions of HES1 and PROP1 in cell differentiation and movement that are critical for pituitary organogenesis
  • regulatory role of PROP1 not only in pituitary organogenesis but also in conversion of PIT1-lineage cells
  • possible transcription factor for gonadotropin subunit genes through plural cis-acting sites composed of AT-rich sequences containing a TAAT motif which differs from its consensus binding sequence
  • dimeric binding of PROP1 is able to recognize diverse palindromic TAAT sequences separated by 3 nucleotides and to exhibit its transcriptional activity
  • pituitary-specific factor and important for the determination of the differentiation of pituitary hormone-producing cells
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • formation of a heterodimer between HESX1 and PROP1 provides a condition in which, in the early pituitary primordium, HESX1 alters its repressive role to an active one by forming a heterodimer with newly appearing PROP1 so that PROP1 finally replaces HESX1 to advance to the middle stage of pituitary development
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • in the presence of PROP1, HESX1 develops to bind to an inverted TAAT motif by forming a heterodimer
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CPHD2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pituitary adenomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Ames dwarf