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| polysyndactyly caused by two recessive mutations in the mouse Lrp4 gene  | |
syndactyly caused by mutations in the bovine Lrp4 gene |
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Lrp4 mutant mice displayed a delay in placode initiation and changes in distribution and number of mammary precursor cells leading to abnormal morphology, number and position of mammary placodes |
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Lrp4(-/-) mice show a delay in ureteric bud formation that results in unilateral or bilateral kidney agenesis |
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Lrp4 null mutations in mice result in limb development defects and in perinatal death due to a lack of neuromuscular junction formation |