Citations for
1CMS17, LRP4
LRP4 is critical for neuromuscular junction maintenance.
Barik A, Lu Y, Sathyamurthy A, Bowman A, Shen C, Li L, Xiong WC, Mei L.
J Neurosci 34(42):13892-905. doi: 10.1523/JNEUROSCI.1733-14.2014. Erratum in: J Neurosci. 2015 May 13;35(19):7655. 2014
2CMS14, LRP4
LRP4 third β-propeller domain mutations cause novel congenital myasthenia by compromising agrin-mediated MuSK signaling in a position-specific manner.
Ohkawara B, Cabrera-Serrano M, Nakata T, Milone M, Asai N, Ito K, Ito M, Masuda A, Ito Y, Engel AG, Ohno K.
Hum Mol Genet 23(7):1856-68. doi: 10.1093/hmg/ddt578. Epub 2013 Nov 13. 2014
3LRP4, SOSTDC1
Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling.
Ahn Y, Sims C, Logue JM, Weatherbee SD, Krumlauf R.
Development 140(3):583-93. doi: 10.1242/dev.085118. 2013
4DOK7, LRP4, MUSK
Structure and activation of MuSK, a receptor tyrosine kinase central to neuromuscular junction formation.
Hubbard SR, Gnanasambandan K.
Biochim Biophys Acta 1834(10):2166-9. doi: 10.1016/j.bbapap.2013.02.034. Epub 2013 Mar 5. Review. 2013
5LRP4, MUSK
Structural mechanisms of the agrin-LRP4-MuSK signaling pathway in neuromuscular junction differentiation.
Zong Y, Jin R.
Cell Mol Life Sci 70(17):3077-88. doi: 10.1007/s00018-012-1209-9. Epub 2012 Nov 22. Review. 2013
6LRP4, MESD
Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes.
Hoshi T, Tezuka T, Yokoyama K, Iemura S, Natsume T, Yamanashi Y.
FEBS Lett 587(23):3749-54. doi: 10.1016/j.febslet.2013.10.001. Epub 2013 Oct 15. 2013
7AGRN, LRP4, MUSK
Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses.
Yumoto N, Kim N, Burden SJ.
Nature 489(7416):438-42. doi: 10.1038/nature11348. 2012
8LRP4, SOST, SOST2
Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function.
Leupin O, Piters E, Halleux C, Hu S, Kramer I, Morvan F, Bouwmeester T, Schirle M, Bueno-Lozano M, Fuentes FJ, Itin PH, Boudin E, de Freitas F, Jennes K, Brannetti B, Charara N, Ebersbach H, Geisse S, Lu CX, Bauer A, Van Hul W, Kneissel M.
J Biol Chem 286(22):19489-500. Epub 2011 Apr 6. 2011
9AGRN, LRP4, MUSK
Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific kinase (MuSK).
Zhang W, Coldefy AS, Hubbard SR, Burden SJ.
J Biol Chem 286(47):40624-30. doi: 10.1074/jbc.M111.279307. Epub 2011 Oct 3. 2011
10ESR1, ESR2, LRP4, LRP5, SOST, TNFRSF11A, TNFRSF11B, TNFSF11, VDR, WLS
Genetics of osteoporosis: accelerating pace in gene identification and validation.
Li WF, Hou SX, Yu B, Li MM, Férec C, Chen JM.
Hum Genet 127(3):249-85. Epub 2009 Dec 12. Review.PMID: 20101412 2010
11CLSS1, LRP4
LRP4 mutations alter Wnt/beta-catenin signaling and cause limb and kidney malformations in Cenani-Lenz syndrome.
Li Y, Pawlik B, Elcioglu N, Aglan M, Kayserili H, Yigit G, Percin F, Goodman F, Nürnberg G, Cenani A, Urquhart J, Chung BD, Ismail S, Amr K, Aslanger AD, Becker C, Netzer C, Scambler P, Eyaid W, Hamamy H, Clayton-Smith J, Hennekam R, Nürnberg P, Herz J, Temtamy SA, Wollnik B.
Am J Hum Genet 86(5):696-706. Epub 2010 Apr 8.PMID: 20381006 2010
12CLSS1, LRP4
Lrp4 regulates initiation of ureteric budding and is crucial for kidney formation--a mouse model for Cenani-Lenz syndrome.
Karner CM, Dietrich MF, Johnson EB, Kappesser N, Tennert C, Percin F, Wollnik B, Carroll TJ, Herz J.
PLoS One 5(4):e10418.PMID: 20454682 2010
13AGRN, LRP4, MUSK
Lrp4 is a receptor for Agrin and forms a complex with MuSK.
Kim N, Stiegler AL, Cameron TO, Hallock PT, Gomez AM, Huang JH, Hubbard SR, Dustin ML, Burden SJ.
Cell 135(2):334-42. Epub 2008 Oct 9. 2008
14AGRN, LRP4
LRP4 serves as a coreceptor of agrin.
Zhang B, Luo S, Wang Q, Suzuki T, Xiong WC, Mei L.
Neuron 60(2):285-97. 2008
15LRP4
Identification of a doublet missense substitution in the bovine LRP4 gene as a candidate causal mutation for syndactyly in Holstein cattle.
Duchesne A, Gautier M, Chadi S, Grohs C, Floriot S, Gallard Y, Caste G, Ducos A, Eggen A.
Genomics 88(5):610-21. Epub 2006 Jul 21. 2006
16LRP4
Defective splicing of Megf7/Lrp4, a regulator of distal limb development, in autosomal recessive mulefoot disease.
Johnson EB, Steffen DJ, Lynch KW, Herz J.
Genomics 88(5):600-9. Epub 2006 Sep 11. 2006
17LRP4
Mutations in the gene encoding the low-density lipoprotein receptor LRP4 cause abnormal limb development in the mouse.
Simon-Chazottes D, Tutois S, Kuehn M, Evans M, Bourgade F, Cook S, Davisson MT, Guenet JL.
Genomics 87(5):673-7. Epub 2006 Mar 6. 2006
18LRP4
A novel low-density lipoprotein receptor-related protein with type II membrane protein-like structure is abundant in heart.
Tomita Y, Kim DH, Magoori K, Fujino T, Yamamoto TT.
J Biochem 124 : 784-789. 1998
19FAT2, CELSR3, CELSR2, MEGF6, MEGF8, MEGF9, LRP4, SLIT1, SLIT3
Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.
Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O.
Genomics 51(1):27-34. 1998