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FLASH GENE

Symbol

LRP4

contributors: mct/npt/pgu - updated : 12-01-2016

HGNC name	low density lipoprotein receptor-related protein 4
HGNC id	6696

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SDTY7 , SOST2 , CMS17

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       associated with bone overgrowth and impaired sclerostin facilitator function

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	polysyndactyly caused by two recessive mutations in the mouse Lrp4 gene
	syndactyly caused by mutations in the bovine Lrp4 gene
	Lrp4 mutant mice displayed a delay in placode initiation and changes in distribution and number of mammary precursor cells leading to abnormal morphology, number and position of mammary placodes
	Lrp4(-/-) mice show a delay in ureteric bud formation that results in unilateral or bilateral kidney agenesis
	Lrp4 null mutations in mice result in limb development defects and in perinatal death due to a lack of neuromuscular junction formation