Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol F2RL3 contributors: mct - updated : 14-11-2015
HGNC name coagulation factor II (thrombin) receptor-like 3
HGNC id 3540
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
HOMOLOGY
Homologene
FAMILY G protein coupled receptor superfamily
CATEGORY receptor
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
basic FUNCTION
  • cofactor for the cleavage and activation of PAR4 (F2RL3) by F2 (mouse)
  • thrombin activated receptor
  • activating platelets after binding thrombin
  • is a previously unknown modulator of visceral nociception
  • involved in signaling of platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation
  • F2R and F2RL3 stimulate different signaling pathways in platelets and likely cooperate to mediate the complete response of the platelets to thrombin
  • is involved in sustained platelet activation, and it invokes sustained intracellular calcium response in platelets, phosphyltidylserine exposure, thrombin generation, and fibrin deposition
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • F2RL2 cofactor for activation by thrombin
  • mediating cathepsin G dependent platelet secretion and aggregation
  • interaction between F2R and F2RL3, F2RL3 also interacts with the P2Y12 receptor on platelets to alter signaling
  • uses its anionic cluster to interact with alpha-thrombin and this interaction is important even in the presence of F2R
  • is a target of MASP1 (MASP1-induced F2RL3 activation could contribute to the development of the inflammatory reaction)
  • F2R and F2RL3 are functionally expressed in large myelinated fibre neurons, and are also expressed in small nociceptors of the peptidergic subclass, where they are able to potentiate TRPV1 activity
  • promotes cell migration via F2RL3
  • thrombin activates platelets by binding and cleaving protease-activated receptors F2R and F2RL3
  • KLK1 gain de function in tubular epithelial cells may mediate pro-inflammatory pathway and F2RL3 activation during diabetic nephropathy
  • PCTP is a regulator of platelet F2RL3 function
    • cell & other
    REGULATION
    activated by thrombin or trypsin,mediates platelets response to cathepsin G
    proteases including thrombin (proteolytic cleavage of its extracellular N terminus,generating a new receptor N terminus which functions as a tethered ligand and activates the receptor
    independently of GPIbalpha and ADP
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    during the progression of colon and prostate cancers
    tumoral     --low  
    occurs frequently in gastric cancers, may result from hypermethylation of the promoter and exhibits association with more aggressive gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • blood-brain barrier disruption and cerebral edema were also attenuated in PAR4-/- mice compared with wild-type animals